Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046452 | biological_process | dihydrofolate metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046655 | biological_process | folic acid metabolic process |
| A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 34 |
| Details | binding site for residue NAP A 201 |
| Chain | Residue |
| A | TRP8 |
| A | ARG46 |
| A | ARG47 |
| A | THR48 |
| A | VAL67 |
| A | THR68 |
| A | ARG69 |
| A | GLN70 |
| A | GLY82 |
| A | ILE100 |
| A | GLY102 |
| A | ALA9 |
| A | ALA103 |
| A | GLN104 |
| A | ILE105 |
| A | TYR106 |
| A | LEU108 |
| A | VYG202 |
| A | EDO205 |
| A | EDO206 |
| A | HOH320 |
| A | HOH321 |
| A | ILE16 |
| A | HOH331 |
| A | HOH340 |
| A | HOH363 |
| A | HOH404 |
| A | HOH415 |
| A | GLY17 |
| A | ARG18 |
| A | GLY20 |
| A | GLY21 |
| A | ILE22 |
| A | GLY45 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue VYG A 202 |
| Chain | Residue |
| A | ILE7 |
| A | TRP8 |
| A | ILE22 |
| A | ASP29 |
| A | LEU30 |
| A | PHE33 |
| A | LYS34 |
| A | PRO53 |
| A | HIS56 |
| A | LEU59 |
| A | ILE100 |
| A | TYR106 |
| A | NAP201 |
| A | HOH320 |
| A | HOH401 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 203 |
| Chain | Residue |
| A | LYS34 |
| A | MET38 |
| A | ARG62 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 204 |
| Chain | Residue |
| A | ALA75 |
| A | ALA78 |
| A | GLN79 |
| A | VAL80 |
| A | HOH372 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 205 |
| Chain | Residue |
| A | ARG18 |
| A | ASP19 |
| A | GLY20 |
| A | ARG47 |
| A | GLU130 |
| A | NAP201 |
| A | EDO206 |
| A | HOH439 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 206 |
| Chain | Residue |
| A | ARG47 |
| A | GLN104 |
| A | GLU130 |
| A | ASP131 |
| A | ALA132 |
| A | NAP201 |
| A | EDO205 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGrdggIPWrlpe.DlahFkrlT |
| Chain | Residue | Details |
| A | VAL15-THR37 | |
