7JTF

Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody RM2-01

Summary for 7JTF

• Entry DOI: 10.2210/pdb7jtf/pdb
• Descriptor: RM2-01 Fab heavy chain, RM2-01 Fab light chain, Envelope glycoprotein E2 (3 entities in total)
• Functional Keywords: hcv, broadly neutralizing antibodies, bnabs, e2 core, ighv1-69, immune system, immune system-viral protein complex, immune system/viral protein
• Biological source: Macaca mulatta; More
• Total number of polymer chains: 6
• Total formula weight: 136525.20

Authors

Tzarum, N.,Wilson, I.A.,Law, M. (deposition date: 2020-08-17, release date: 2021-03-10, Last modification date: 2023-10-18)

• Primary citation: Tzarum, N.,Chen, F.,Lin, X.,Giang, E.,Velazquez-Moctezuma, R.,Augestad, E.H.,Nagy, K.,He, L.,Davidson, E.,Chavez, D.,Prentoe, J.,Stanfield, R.L.,Lanford, R.,Bukh, J.,Wilson, I.A.,Zhu, J.,Law, M.; HCV Env immunization elicits a rapid VH1-69-like broadly neutralizing antibody response in rhesus macaques; Immunity, 2021

Experimental method

X-RAY DIFFRACTION (3.35 Å)