7JTF

Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody RM2-01

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, C)	RM2-01 Fab heavy chain	polymer	229	24107.2	2		Macaca mulatta
2	B, E (B, D)	RM2-01 Fab light chain	polymer	214	23448.0	2		Macaca mulatta
3	C, F (E, F)	Envelope glycoprotein E2	polymer	189	20707.4	2	UniProt (B9V0E2)	Recombinant Hepatitis C virus HK6a/JFH-1

Sequence modifications

E, F: 412 - 481 (UniProt: B9V0E2)

PDB	External Database	Details
Asp 448	Asn 448	engineered mutation

E, F: 486 - 591 (UniProt: B9V0E2)

PDB	External Database	Details
Gly 482	-	linker
Ser 483	-	linker
Ser 484	-	linker
Gly 485	-	linker

E, F: 594 - 596 (UniProt: B9V0E2)

PDB	External Database	Details
Gly 592	-	linker
Gly 593	-	linker

E, F: 598 - 645 (UniProt: B9V0E2)

PDB	External Database	Details
Gly 597	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	136525.2
All*	Total formula weight	136525.2

*Water molecules are not included.