PDB: 608 件ウェブページステータス検索Chemie searchBIRD

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7OBL	Crystal structure of 14-3-3 sigma in complex with PKR phosphopeptide and stabilizer Fusicoccin-A 分子名称: 14-3-3 protein sigma, FUSICOCCIN, MAGNESIUM ION, ... 著者 Centorrino, F, Andlovic, B, Ottmann, C. 登録日 2021-04-22 公開日 2022-05-04 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
7OBS	Crystal structure of 14-3-3 sigma in complex with RIPK2 phosphopeptide 分子名称: 14-3-3 protein sigma, CALCIUM ION, MAGNESIUM ION, ... 著者 Centorrino, F, Andlovic, B, Ottmann, C. 登録日 2021-04-23 公開日 2022-05-04 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 IFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization. Cell Chem Biol, 2023
8C1Y	Small molecule stabilizer for 14-3-3/ChREBP (Cmd 30) 分子名称: 14-3-3 protein sigma, Carbohydrate-responsive element-binding protein, [2-[2-[[2,2-bis(fluoranyl)-2-phenyl-ethyl]amino]-2-oxidanylidene-ethoxy]phenyl]phosphonic acid 著者 Pennings, M.A.M, Visser, E.J, Ottmann, C. 登録日 2022-12-21 公開日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity. Biorxiv, 2024
5MOC	Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide 分子名称: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... 著者 Andrei, S, Ottmann, C, Leysen, S. 登録日 2016-12-14 公開日 2017-10-04 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction. FEBS Lett., 591, 2017
7ZMW	14-3-3s binding to non-natural peptide 2c 分子名称: 14-3-3 protein sigma, MAGNESIUM ION, non-natural peptide 1 著者 Somsen, B.A, Craenmehr, F.W.B, Ottmann, C. 登録日 2022-04-19 公開日 2022-11-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Functional mapping of the 14-3-3 hub protein as a guide to design 14-3-3 molecular glues. Chem Sci, 13, 2022
4Y3B	Crystal structure of C-terminal modified Tau peptide-hybrid 201D with 14-3-3sigma 分子名称: (2S)-2-(2-methoxyethyl)pyrrolidine, 14-3-3 protein sigma, ARG-THR-PRO-SEP-LEU-PRO-THR-[H][C@@]1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCCN1C 著者 Bartel, M, Milroy, L.G, Brunsveld, L, Ottmann, C. 登録日 2015-02-10 公開日 2015-12-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Stabilizer-Guided Inhibition of Protein-Protein Interactions. Angew.Chem.Int.Ed.Engl., 54, 2015
7OR7	Ternary complex of 14-3-3 sigma, NotchpS1917 phosphopeptide, and WQ178 分子名称: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... 著者 Centorrino, F, Wu, Q, Ottmann, C. 登録日 2021-06-04 公開日 2022-07-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A crystallography-based study of fragment extensions into the 14-3-3 binding groove To Be Published
7OR5	Ternary complex of 14-3-3 sigma, NotchpS1917 phosphopeptide, and WQ162 分子名称: 14-3-3 protein sigma, CHLORIDE ION, Neurogenic locus notch homolog protein 4, ... 著者 Centorrino, F, Wu, Q, Ottmann, C. 登録日 2021-06-04 公開日 2022-07-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A crystallography-based study of fragment extensions into the 14-3-3 binding groove To Be Published
5N5T	14-3-3 sigma in complex with TAZ pS89 peptide and fragment NV2 分子名称: 14-3-3 protein sigma, 4-[3,5-bis(chloranyl)pyridin-2-yl]oxyphenol, CHLORIDE ION, ... 著者 Sijbesma, E, Leysen, S, Ottmann, C. 登録日 2017-02-14 公開日 2017-07-19 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening. Biochemistry, 56, 2017
7OQA	Ternary complex of 14-3-3 sigma, Pin1pS72 phosphopeptide, and WQ162 分子名称: 14-3-3 protein sigma, CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ... 著者 Centorrino, F, Ottmann, C. 登録日 2021-06-02 公開日 2022-08-10 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A crystallography-based study of fragment extensions into the 14-3-3 binding groove To Be Published
7OQ9	Ternary complex of 14-3-3 sigma, Pin1pS72 phosphopeptide, and WQ136 分子名称: 14-3-3 protein sigma, CHLORIDE ION, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ... 著者 Centorrino, F, Ottmann, C. 登録日 2021-06-02 公開日 2022-08-10 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A crystallography-based study of fragment extensions into the 14-3-3 binding groove To Be Published
6YOY	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-025 分子名称: 14-3-3 protein sigma, 5-methyl-2-nitrophenol, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2020-04-15 公開日 2020-09-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering. Angew.Chem.Int.Ed.Engl., 59, 2020
6YP2	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-011 分子名称: 1-(4-methylphenyl)imidazole, 14-3-3 protein sigma, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2020-04-15 公開日 2020-09-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering. Angew.Chem.Int.Ed.Engl., 59, 2020
7ORS	Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ147 分子名称: (4~{S})-~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]oxepane-4-carboxamide, 14-3-3 protein sigma, CHLORIDE ION, ... 著者 Centorrino, F, Wu, Q, Ottmann, C. 登録日 2021-06-06 公開日 2022-06-22 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A crystallography-based study of fragment extensions into the 14-3-3 binding groove To Be Published
7ORG	Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ162 分子名称: 14-3-3 protein sigma, CHLORIDE ION, Cyclin-dependent kinase inhibitor 1B, ... 著者 Centorrino, F, Wu, Q, Ottmann, C. 登録日 2021-06-05 公開日 2022-06-22 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A crystallography-based study of fragment extensions into the 14-3-3 binding groove To Be Published
7OR3	Ternary complex of 14-3-3 sigma, NotchpS1917 phosphopeptide, and WQ136 分子名称: 14-3-3 protein sigma, CHLORIDE ION, MAGNESIUM ION, ... 著者 Centorrino, F, Wu, Q, Ottmann, C. 登録日 2021-06-04 公開日 2022-06-22 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A crystallography-based study of fragment extensions into the 14-3-3 binding groove To Be Published
7ORH	Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ178 分子名称: 14-3-3 protein sigma, CHLORIDE ION, Cyclin-dependent kinase inhibitor 1B, ... 著者 Centorrino, F, Wu, Q, Ottmann, C. 登録日 2021-06-05 公開日 2022-06-22 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A crystallography-based study of fragment extensions into the 14-3-3 binding groove To Be Published
7OR8	Ternary complex of 14-3-3 sigma, p27pT198 phosphopeptide, and WQ136 分子名称: 14-3-3 protein sigma, CALCIUM ION, CHLORIDE ION, ... 著者 Centorrino, F, Wu, Q, Ottmann, C. 登録日 2021-06-04 公開日 2022-06-22 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A crystallography-based study of fragment extensions into the 14-3-3 binding groove To Be Published
6YP3	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-028 分子名称: 1-(4-methylphenyl)-1,2,4-triazole, 14-3-3 protein sigma, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2020-04-15 公開日 2020-09-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering. Angew.Chem.Int.Ed.Engl., 59, 2020
6YP8	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-033 分子名称: 14-3-3 protein sigma, 3-imidazol-1-ylbenzaldehyde, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2020-04-15 公開日 2020-09-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering. Angew.Chem.Int.Ed.Engl., 59, 2020
6YPL	14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-037 分子名称: (2-methylsulfonylphenyl)methanol, 14-3-3 protein sigma, CHLORIDE ION, ... 著者 Wolter, M, Ottmann, C. 登録日 2020-04-16 公開日 2020-09-23 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Fragment-Based Stabilizers of Protein-Protein Interactions through Imine-Based Tethering. Angew.Chem.Int.Ed.Engl., 59, 2020
6YE9	Small-molecule inhibitor of 14-3-3 protein-protein interactions 分子名称: 14-3-3 protein sigma, MAGNESIUM ION, [2-[2-oxidanylidene-2-[(phenylmethyl)amino]ethoxy]phenyl]phosphonic acid 著者 Ottmann, C, Visser, E.J. 登録日 2020-03-24 公開日 2021-03-31 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-based conversion of a promiscuous inhibitor to a selective stabilizer of protein-protein interactions To Be Published
3SMO	Crystal structure of human 14-3-3 sigma C38V/N166H in complex with TASK-3 peptide and stabilizer Fusicoccin J aglycone 分子名称: 14-3-3 protein sigma, Fusicoccin J aglycone, MAGNESIUM ION, ... 著者 Anders, C, Schumacher, B, Ottmann, C. 登録日 2011-06-28 公開日 2012-07-11 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface. Chem. Biol., 20, 2013
7NJ8	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1007 分子名称: 14-3-3 protein sigma, CALCIUM ION, MAGNESIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2021-02-16 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021
7BGR	14-3-3 sigma with Pin1 binding site pS72 and covalently bound LvD1016 分子名称: 14-3-3 protein sigma, 2-methyl-4-(2-phenylimidazol-1-yl)benzaldehyde, CALCIUM ION, ... 著者 Wolter, M, Dijck, L.v, Cossar, P.J, Ottmann, C. 登録日 2021-01-08 公開日 2021-06-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions. J.Am.Chem.Soc., 143, 2021

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