1K8R
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1k8r by Molmil](/molmil-images/mine/1k8r) | Crystal structure of Ras-Bry2RBD complex | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Protein kinase byr2, ... | 著者 | Scheffzek, K, Gruenewald, P, Wohlgemuth, S, Kabsch, W, Tu, H, Wigler, M, Wittinghofer, A, Herrmann, C. | 登録日 | 2001-10-25 | 公開日 | 2002-03-13 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast. Structure, 9, 2001
|
|
2OCB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ocb by Molmil](/molmil-images/mine/2ocb) | Crystal structure of human RAB9B in complex with a GTP analogue | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras-related protein Rab-9B, ... | 著者 | Hong, B, Shen, L, Walker, J.R, Tempel, W, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | 登録日 | 2006-12-20 | 公開日 | 2007-01-02 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of human RAB9B in complex with a GTP analogue To be Published
|
|
1IAQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1iaq by Molmil](/molmil-images/mine/1iaq) | C-H-RAS P21 PROTEIN MUTANT WITH THR 35 REPLACED BY SER (T35S) COMPLEXED WITH GUANOSINE-5'-[B,G-IMIDO] TRIPHOSPHATE | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, TRANSFORMING PROTEIN P21/H-RAS-1 | 著者 | Spoerner, M, Herrmann, C, Vetter, I.R, Kalbitzer, H.R, Wittinghofer, A. | 登録日 | 2001-03-23 | 公開日 | 2001-06-06 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Dynamic properties of the Ras switch I region and its importance for binding to effectors. Proc.Natl.Acad.Sci.USA, 98, 2001
|
|
2P5S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2p5s by Molmil](/molmil-images/mine/2p5s) | RAB domain of human RASEF in complex with GDP | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, RAS and EF-hand domain containing, UNKNOWN ATOM OR ION | 著者 | Zhu, H, Wang, J, Shen, Y, Tempel, W, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | 登録日 | 2007-03-16 | 公開日 | 2007-03-27 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | RAB domain of human RASEF in complex with GDP To be Published
|
|
1KMQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1kmq by Molmil](/molmil-images/mine/1kmq) | Crystal Structure of a Constitutively Activated RhoA Mutant (Q63L) | 分子名称: | 1,4-DIETHYLENE DIOXIDE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | 著者 | Longenecker, K, Read, P, Lin, S.-K, Somlyo, A.P, Nakamoto, R.K, Derewenda, Z.S. | 登録日 | 2001-12-17 | 公開日 | 2003-05-06 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structure of a constitutively activated RhoA mutant (Q63L) at 1.55 A resolution. Acta Crystallogr.,Sect.D, 59, 2003
|
|
1HUQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1huq by Molmil](/molmil-images/mine/1huq) | 1.8A CRYSTAL STRUCTURE OF THE MONOMERIC GTPASE RAB5C (MOUSE) | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, RAB5C | 著者 | Merithew, E, Hatherly, S, Dumas, J.J, Lawe, D.C, Heller-Harrison, R, Lambright, D.G. | 登録日 | 2001-01-04 | 公開日 | 2001-02-07 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural plasticity of an invariant hydrophobic triad in the switch regions of Rab GTPases is a determinant of effector recognition. J.Biol.Chem., 276, 2001
|
|
1KAO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1kao by Molmil](/molmil-images/mine/1kao) | CRYSTAL STRUCTURE OF THE SMALL G PROTEIN RAP2A WITH GDP | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RAP2A | 著者 | Cherfils, J, Menetrey, J, Le Bras, G. | 登録日 | 1997-08-01 | 公開日 | 1997-12-24 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS. EMBO J., 16, 1997
|
|
2N42
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2n42 by Molmil](/molmil-images/mine/2n42) | EC-NMR Structure of Human H-RasT35S mutant protein Determined by Combining Evolutionary Couplings (EC) and Sparse NMR Data | 分子名称: | GTPase HRas | 著者 | Tang, Y, Huang, Y.J, Hopf, T.A, Sander, C, Marks, D, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2015-06-16 | 公開日 | 2015-07-01 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Protein structure determination by combining sparse NMR data with evolutionary couplings. Nat.Methods, 12, 2015
|
|
2P2L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2p2l by Molmil](/molmil-images/mine/2p2l) | Rac1-GDP-Zinc Complex | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Ras-related C3 botulinum toxin substrate 1, ZINC ION | 著者 | Prehna, G, Stebbins, C.E. | 登録日 | 2007-03-07 | 公開日 | 2007-05-01 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A Rac1-GDP trimer complex binds zinc with tetrahedral and octahedral coordination, displacing magnesium. Acta Crystallogr.,Sect.D, 63, 2007
|
|
1KY2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ky2 by Molmil](/molmil-images/mine/1ky2) | |
2LCF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2lcf by Molmil](/molmil-images/mine/2lcf) | Solution structure of GppNHp-bound H-RasT35S mutant protein | 分子名称: | GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 著者 | Araki, M, Shima, F, Yoshikawa, Y, Muraoka, S, Ijiri, Y, Nagahara, Y, Shirono, T, Kataoka, T, Tamura, A. | 登録日 | 2011-04-28 | 公開日 | 2011-09-28 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the state 1 conformer of GTP-bound H-Ras protein and distinct dynamic properties between the state 1 and state 2 conformers. J.Biol.Chem., 286, 2011
|
|
1LF5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1lf5 by Molmil](/molmil-images/mine/1lf5) | |
2L0X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2l0x by Molmil](/molmil-images/mine/2l0x) | Solution structure of the 21 kDa GTPase RHEB bound to GDP | 分子名称: | GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | 著者 | Stoll, R, Heumann, R, Berghaus, C, Kock, G. | 登録日 | 2010-07-19 | 公開日 | 2010-08-04 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Ras homolog enriched in brain (Rheb) enhances apoptotic signaling. J.Biol.Chem., 285, 2010
|
|
2MMG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2mmg by Molmil](/molmil-images/mine/2mmg) | Structural Characterization of the Mengovirus Leader Protein Bound to Ran GTPase by Nuclear Magnetic Resonance | 分子名称: | GTP-binding nuclear protein Ran | 著者 | Bacot-Davis, V.R, Palmenberg, A.C, Cornilescu, C.C, Markley, J.L. | 登録日 | 2014-03-15 | 公開日 | 2014-10-15 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structures of Mengovirus Leader protein, its phosphorylated derivatives, and in complex with nuclear transport regulatory protein, RanGTPase. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
2LWI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2lwi by Molmil](/molmil-images/mine/2lwi) | Solution structure of H-RasT35S mutant protein in complex with Kobe2601 | 分子名称: | 2-(2,4-dinitrophenyl)-N-(4-fluorophenyl)hydrazinecarbothioamide, GTPase HRas, MAGNESIUM ION, ... | 著者 | Araki, M, Tamura, A, Shima, F, Kataoka, T. | 登録日 | 2012-08-01 | 公開日 | 2013-05-22 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
2MMC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2mmc by Molmil](/molmil-images/mine/2mmc) | |
2Q3H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2q3h by Molmil](/molmil-images/mine/2q3h) | The crystal structure of RhouA in the GDP-bound state. | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras homolog gene family, ... | 著者 | Gileadi, C, Yang, X, Papagrigoriou, E, Elkins, J, Zhao, Y, Bray, J, Gileadi, O, Umeano, C, Ugochukwu, E, Uppenberg, J, Bunkoczi, G, von Delft, F, Pike, A.C.W, Phillips, C, Savitsky, P, Fedorov, O, Edwards, A, Weigelt, J, Arrowsmith, C.H, Sundstrom, M, Doyle, D.A, Structural Genomics Consortium (SGC) | 登録日 | 2007-05-30 | 公開日 | 2007-06-19 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | The crystal structure of RhouA in the GDP-bound state. To be Published
|
|
2Q21
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2q21 by Molmil](/molmil-images/mine/2q21) | |
6YR8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6yr8 by Molmil](/molmil-images/mine/6yr8) | Affimer K6 - KRAS protein complex | 分子名称: | Affimer K6, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Trinh, C.H, Haza, K.Z, Rao, A, Martin, H.L, Tiede, C, Edwards, T.A, McPherson, M.J, Tomlinson, D.C. | 登録日 | 2020-04-19 | 公開日 | 2020-07-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | RAS-inhibiting biologics identify and probe druggable pockets including an SII-alpha 3 allosteric site. Nat Commun, 12, 2021
|
|
6Y7G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6y7g by Molmil](/molmil-images/mine/6y7g) | Structure of the human RAB3C in complex with GDP | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Diaz-Saez, L, Jung, S, Raux, B, Burgess-Brown, N.A, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Huber, K.V.M, Structural Genomics Consortium (SGC) | 登録日 | 2020-02-29 | 公開日 | 2021-03-31 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure of the human RAB3C in complex with GDP To Be Published
|
|
6YXW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6yxw by Molmil](/molmil-images/mine/6yxw) | Affimer K3 - KRAS protein complex | 分子名称: | Affimer K3, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Trinh, C.H, Haza, K.Z, Rao, A, Martin, H.L, Tiede, C, Edwards, T.A, McPherson, M.J, Tomlinson, D.C. | 登録日 | 2020-05-04 | 公開日 | 2020-07-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | RAS-inhibiting biologics identify and probe druggable pockets including an SII-alpha 3 allosteric site. Nat Commun, 12, 2021
|
|
6ZIO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6zio by Molmil](/molmil-images/mine/6zio) | |
6ZIZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ziz by Molmil](/molmil-images/mine/6ziz) | CRYSTAL STRUCTURE OF NRAS Q61R IN COMPLEX WITH GTP AND COMPOUND 18 | 分子名称: | (3~{S})-3-[2-[(dimethylamino)methyl]-1~{H}-indol-3-yl]-5-oxidanyl-2,3-dihydroisoindol-1-one, GTPase NRas, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Kessler, D, Fischer, G, Boettcher, J. | 登録日 | 2020-06-26 | 公開日 | 2020-08-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.785 Å) | 主引用文献 | Drugging all RAS isoforms with one pocket. Future Med Chem, 12, 2020
|
|
6ZJ0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6zj0 by Molmil](/molmil-images/mine/6zj0) | CRYSTAL STRUCTURE OF HRAS-G12D IN COMPLEX WITH GCP AND COMPOUND 18 | 分子名称: | (3~{S})-3-[2-[(dimethylamino)methyl]-1~{H}-indol-3-yl]-5-oxidanyl-2,3-dihydroisoindol-1-one, GTPase HRas, MAGNESIUM ION, ... | 著者 | Kessler, D, Fischer, G, Boettcher, J. | 登録日 | 2020-06-26 | 公開日 | 2020-08-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.763 Å) | 主引用文献 | Drugging all RAS isoforms with one pocket. Future Med Chem, 12, 2020
|
|
7ACF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7acf by Molmil](/molmil-images/mine/7acf) | |