PDB: 46006 件ウェブページステータス検索Chemie searchBIRD

---

3NOA	Crystal structure of human PPAR-gamma ligand binding domain complex with a potency improved agonist 分子名称: (5-{3-[4-(biphenyl-4-ylcarbonyl)-2-propylphenoxy]propoxy}-1H-indol-1-yl)acetic acid, Peroxisome proliferator-activated receptor gamma 著者 Peng, Y.H, Wu, J.S, Wu, S.Y. 登録日 2010-06-25 公開日 2011-06-29 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Crystal structure of human PPAR-gamma ligand binding domain complex with a potency improved agonist To be published
7QSD	Bovine complex I in the active state at 3.1 A 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... 著者 Bridges, H.R, Blaza, J.N, Yin, Z, Chung, I, Hirst, J. 登録日 2022-01-13 公開日 2022-03-02 最終更新日 2023-03-08 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides. Science, 379, 2023
4YOS	p107 pocket domain complexed with LIN52 peptide 分子名称: 1,2-ETHANEDIOL, Protein lin-52 homolog, Retinoblastoma-like protein 1,Retinoblastoma-like protein 1, ... 著者 Guiley, K.Z, Liban, T.J, Felthousen, J.G, Ramanan, P, Tripathi, S, Litovchick, L, Rubin, S.M. 登録日 2015-03-12 公開日 2015-05-27 最終更新日 2019-12-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural mechanisms of DREAM complex assembly and regulation. Genes Dev., 29, 2015
4YBU	Crystal structure of the R111K:Y134F:T54V:R132Q:P39Q:R59Y mutant of human Cellular Retinoic Acid Binding ProteinII in complex with Retinal after 24 h incubation and 1 hour UV irradiation at 1.92 angstrom - 1st cycle 分子名称: Cellular retinoic acid-binding protein 2, RETINAL 著者 Nosrati, M, Geiger, J.H. 登録日 2015-02-19 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.924 Å) 主引用文献 A Photoisomerizing Rhodopsin Mimic Observed at Atomic Resolution. J.Am.Chem.Soc., 138, 2016
4YCH	Crystal Structure of R111K:Y134F:T54V:R132Q:P39Q:R59Y mutant of human Cellular Retinoic Acid Binding ProteinII with Retinal at 1.96 Angstrom - UV irradiated Crystal for 1 hour - 2nd cycle 分子名称: Cellular retinoic acid-binding protein 2, RETINAL 著者 Nosrati, M, Geiger, J.H. 登録日 2015-02-20 公開日 2016-02-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 A Photoisomerizing Rhodopsin Mimic Observed at Atomic Resolution. J.Am.Chem.Soc., 138, 2016
470D	CRYSTAL STRUCTURE AND IMPROVED ANTISENSE PROPERTIES OF 2'-O-(2-METHOXYETHYL)-RNA 分子名称: MAGNESIUM ION, RNA (5'-R(*(C43)P*(G48)P*(C43)P*(G48)P*(A44)P*(A44)P*(U36)P*(U36)P*(C43)P*(G48)P*(C43)P*(G48))-3') 著者 Teplova, M, Minasov, G, Tereshko, V, Inamati, G, Cook, P.D, Egli, M. 登録日 1999-04-29 公開日 1999-05-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA. Nat.Struct.Biol., 6, 1999
5KM3	Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) UMP catalytic product complex 分子名称: GLYCEROL, Histidine triad nucleotide-binding protein 1, URIDINE-5'-MONOPHOSPHATE 著者 Maize, K.M, Finzel, B.C. 登録日 2016-06-26 公開日 2017-06-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides. Mol. Pharm., 14, 2017
7QGS	Crystal structure of p300 CH1 domain in complex with CITIF (a CITED2-HIF-1alpha hybrid) 分子名称: Cbp/p300-interacting transactivator 2,Hypoxia-inducible factor 1-alpha, Histone acetyltransferase, ZINC ION 著者 Hegedus, Z, Wilson, A.J, Edwards, T.A. 登録日 2021-12-10 公開日 2022-05-11 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Understanding p300-transcription factor interactions using sequence variation and hybridization. Rsc Chem Biol, 3, 2022
5KM1	Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) GMP catalytic product complex 分子名称: 1,2-ETHANEDIOL, GUANOSINE-5'-MONOPHOSPHATE, Histidine triad nucleotide-binding protein 1 著者 Maize, K.M, Finzel, B.C. 登録日 2016-06-26 公開日 2017-06-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides. Mol. Pharm., 14, 2017
5KMA	Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant nucleoside D-Trp phosphoramidate substrate complex 分子名称: CHLORIDE ION, Histidine triad nucleotide-binding protein 1, [(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-3~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-ethyl-phosphonamidic acid 著者 Maize, K.M, Finzel, B.C. 登録日 2016-06-26 公開日 2017-06-28 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides. Mol. Pharm., 14, 2017
3OGT	Design, Chemical synthesis, Functional characterization and Crystal structure of the sidechain analogue of 1,25-dihydroxyvitamin D3. 分子名称: (1S,3R,5Z,7E,14beta,17alpha,20S)-20-[5-(1-hydroxy-1-methylethyl)furan-2-yl]-9,10-secopregna-5,7,10-triene-1,3-diol, SULFATE ION, Vitamin D3 receptor 著者 Huet, T, Fraga, R, Mourino, A, Moras, D, Rochel, N. 登録日 2010-08-17 公開日 2011-08-17 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Design, Chemical synthesis, Functional characterization and Crystal structure of the sidechain analogue of 1,25-dihydroxyvitamin D3. To be Published
7QSM	Bovine complex I in lipid nanodisc, Deactive-ligand (composite) 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... 著者 Chung, I, Bridges, H.R, Hirst, J. 登録日 2022-01-13 公開日 2022-05-25 最終更新日 2022-09-28 実験手法 ELECTRON MICROSCOPY (2.3 Å) 主引用文献 Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy. Nat Commun, 13, 2022
7QSL	Bovine complex I in lipid nanodisc, Active-apo 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... 著者 Chung, I, Bridges, H.R, Hirst, J. 登録日 2022-01-13 公開日 2022-05-25 最終更新日 2022-09-28 実験手法 ELECTRON MICROSCOPY (2.76 Å) 主引用文献 Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy. Nat Commun, 13, 2022
5KTX	CREBBP bromodomain in complex with Cpd59 ((S)-1-(3-((2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)-1-(tetrahydrofuran-3-yl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)ethanone) 分子名称: 1,2-ETHANEDIOL, 1-[3-[[2-fluoranyl-4-(1-methylpyrazol-4-yl)phenyl]amino]-1-[(3~{S})-oxolan-3-yl]-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-5-yl]ethanone, CREB-binding protein, ... 著者 Murray, J.M, Noland, C. 登録日 2016-07-12 公開日 2016-11-02 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.27 Å) 主引用文献 Discovery of a Potent and Selective in Vivo Probe (GNE-272) for the Bromodomains of CBP/EP300. J. Med. Chem., 59, 2016
7QSN	Bovine complex I in lipid nanodisc, Deactive-apo 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... 著者 Chung, I, Bridges, H.R, Hirst, J. 登録日 2022-01-13 公開日 2022-05-25 最終更新日 2022-09-28 実験手法 ELECTRON MICROSCOPY (2.81 Å) 主引用文献 Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy. Nat Commun, 13, 2022
7QSK	Bovine complex I in lipid nanodisc, Active-Q10 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... 著者 Chung, I, Bridges, H.R, Hirst, J. 登録日 2022-01-13 公開日 2022-05-25 最終更新日 2022-09-28 実験手法 ELECTRON MICROSCOPY (2.84 Å) 主引用文献 Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy. Nat Commun, 13, 2022
7QSO	Bovine complex I in lipid nanodisc, State 3 (Slack) 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ... 著者 Chung, I, Bridges, H.R, Hirst, J. 登録日 2022-01-13 公開日 2022-05-25 最終更新日 2022-09-28 実験手法 ELECTRON MICROSCOPY (3.02 Å) 主引用文献 Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy. Nat Commun, 13, 2022
3FWB	Sac3:Sus1:Cdc31 complex 分子名称: Cell division control protein 31, Nuclear mRNA export protein SAC3, Protein SUS1 著者 Stewart, M, Jani, D. 登録日 2009-01-17 公開日 2009-04-14 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Sus1, Cdc31, and the Sac3 CID region form a conserved interaction platform that promotes nuclear pore association and mRNA export. Mol.Cell, 33, 2009
4YXP	The structure of the folded domain of the signature multifunctional protein ICP27 from herpes simplex virus-1 reveals an intertwined dimer. 分子名称: ZINC ION, mRNA export factor 著者 Tunnicliffe, R.B, Schacht, M, Levy, C.W, Jowitt, T.A, Sandri-Goldin, R.M, Golovanov, A.P. 登録日 2015-03-23 公開日 2015-06-17 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 The structure of the folded domain from the signature multifunctional protein ICP27 from herpes simplex virus-1 reveals an intertwined dimer. Sci Rep, 5, 2015
8V84	60S ribosome biogenesis intermediate (Dbp10 catalytic structure - Overall map) 分子名称: 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 60S ribosomal protein L13-A, 60S ribosomal protein L14-A, ... 著者 Cruz, V.E, Weirich, C.S, Peddada, N, Erzberger, J.P. 登録日 2023-12-04 公開日 2024-05-01 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 The DEAD-box ATPase Dbp10/DDX54 initiates peptidyl transferase center formation during 60S ribosome biogenesis. Nat Commun, 15, 2024
8V83	60S ribosome biogenesis intermediate (Dbp10 pre-catalytic structure - Overall map) 分子名称: 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 60S ribosomal protein L13-A, 60S ribosomal protein L14-A, ... 著者 Cruz, V.E, Weirich, C.S, Peddada, N, Erzberger, J.P. 登録日 2023-12-04 公開日 2024-05-01 実験手法 ELECTRON MICROSCOPY (2.53 Å) 主引用文献 The DEAD-box ATPase Dbp10/DDX54 initiates peptidyl transferase center formation during 60S ribosome biogenesis. Nat Commun, 15, 2024
5IQL	Crystal structure of YEATS2 YEATS bound to H3K27cr peptide 分子名称: Histone H3.1, YEATS domain-containing protein 2 著者 Li, H, Zhao, D, Guan, H. 登録日 2016-03-11 公開日 2016-07-20 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 YEATS2 is a selective histone crotonylation reader. Cell Res., 26, 2016
4Z5R	Rontalizumab Fab bound to Interferon-a2 分子名称: Interferon alpha-2, SULFATE ION, anti-IFN-a antibody rontalizumab heavy chain modules VH and CH1 (Fab), ... 著者 Eigenbrot, C, Maurer, B, Bosanac, I. 登録日 2015-04-02 公開日 2015-07-08 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis of the broadly neutralizing anti-interferon-alpha antibody rontalizumab. Protein Sci., 24, 2015
6Q7U	Crystal structure of PqsR (MvfR) ligand-binding domain in complex with HHQ 分子名称: 2-heptyl-1~{H}-quinolin-4-one, Transcriptional regulator MvfR 著者 Witzgall, F, Xu, N, Blankenfeldt, W. 登録日 2018-12-13 公開日 2019-11-20 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.14 Å) 主引用文献 Flexible Fragment Growing Boosts Potency of Quorum-Sensing Inhibitors against Pseudomonas aeruginosa Virulence. Chemmedchem, 15, 2020
5IOK	Crystal structure of Taf14 YEATS domain in complex with histone H3K9cr 分子名称: (ACE)QTAR(KCR)ST, DI(HYDROXYETHYL)ETHER, Transcription initiation factor TFIID subunit 14 著者 Andrews, F.H, Kuateladze, T.G. 登録日 2016-03-08 公開日 2016-04-20 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 The Taf14 YEATS domain is a reader of histone crotonylation. Nat.Chem.Biol., 12, 2016

<1267126812691270127112721273127412751276127712781279128012811282>