6Q7U
Crystal structure of PqsR (MvfR) ligand-binding domain in complex with HHQ
Summary for 6Q7U
| Entry DOI | 10.2210/pdb6q7u/pdb |
| Descriptor | Transcriptional regulator MvfR, 2-heptyl-1~{H}-quinolin-4-one (3 entities in total) |
| Functional Keywords | quorum sensing, lysr-type transcriptional regulator, pseudomonas quinolone signaling system, lttr, dna binding protein |
| Biological source | Pseudomonas aeruginosa PAO1 |
| Total number of polymer chains | 1 |
| Total formula weight | 25943.41 |
| Authors | Witzgall, F.,Xu, N.,Blankenfeldt, W. (deposition date: 2018-12-13, release date: 2019-11-20, Last modification date: 2024-01-24) |
| Primary citation | Zender, M.,Witzgall, F.,Kiefer, A.,Kirsch, B.,Maurer, C.K.,Kany, A.M.,Xu, N.,Schmelz, S.,Borger, C.,Blankenfeldt, W.,Empting, M. Flexible Fragment Growing Boosts Potency of Quorum-Sensing Inhibitors against Pseudomonas aeruginosa Virulence. Chemmedchem, 15:188-194, 2020 Cited by PubMed: 31709767DOI: 10.1002/cmdc.201900621 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.14 Å) |
Structure validation
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