PDB: 46188 件ウェブページステータス検索Chemie searchBIRD

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6BCU	Cryo-EM structure of the activated RHEB-mTORC1 refined to 3.4 angstrom 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E-binding protein 1, GTP-binding protein Rheb, ... 著者 Pavletich, N.P, Yang, H. 登録日 2017-10-20 公開日 2017-12-20 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40. Nature, 552, 2017
6S53	Crystal structure of TRIM21 RING domain in complex with an isopeptide-linked Ube2N~ubiquitin conjugate 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, E3 ubiquitin-protein ligase TRIM21, Polyubiquitin-C, ... 著者 Kiss, L, Boland, A, Neuhaus, D, James, L.C. 登録日 2019-06-30 公開日 2019-09-11 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases. Nat Commun, 10, 2019
7XC1	Crystal structure of ERK2 with an allosteric inhibitor 3 分子名称: (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, ... 著者 Yoshida, M, Kinoshita, T. 登録日 2022-03-22 公開日 2023-03-22 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 Structural basis for ERK2 allosteric inhibitors. To Be Published
8QAO	Crystal structure of TP901-1 CI-NTD89 repressor N-terminal domain 分子名称: CI 著者 Huang, Z, Hamad, G.M, Lo Leggio, L, Varming, A.K. 登録日 2023-08-23 公開日 2024-02-28 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.29 Å) 主引用文献 CI:Mor interactions in the lysogeny switches of Lactococcus lactis TP901-1 and Staphylococcus aureus phi 13 bacteriophages. Microbiome Res Rep, 3, 2024
5CH6	Crystal Structure of FRIGIDA Flowering-time Regulator 分子名称: FRIGIDA 著者 Hyun, K, Song, J.J. 登録日 2015-07-10 公開日 2016-05-25 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (3.26 Å) 主引用文献 Structural Analysis of FRIGIDA Flowering-Time Regulator Mol Plant, 9, 2016
8QA8	Crystal structure of the C-terminally truncated transcriptional repressor protein KorB from the RK2 plasmid complexed with CTP-gamma-S 分子名称: CHLORIDE ION, CYTIDINE-5'-TRIPHOSPHATE, Transcriptional repressor protein KorB 著者 McLean, T.C, Mundy, J.E.A, Lawson, D.M, Le, T.B.K. 登録日 2023-08-22 公開日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of the C-terminally truncated transcriptional repressor protein KorB from the RK2 plasmid complexed with CTP-gamma-S To Be Published
6F1S	C-terminal domain of CglI restriction endonuclease H subunit 分子名称: 1,2-ETHANEDIOL, CglIIR protein, FORMIC ACID 著者 Tamulaitiene, G, Grigaitis, R, Zaremba, M, Silanskas, A. 登録日 2017-11-23 公開日 2018-02-14 最終更新日 2019-01-16 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 The H-subunit of the restriction endonuclease CglI contains a prototype DEAD-Z1 helicase-like motor. Nucleic Acids Res., 46, 2018
2YCQ	Crystal structure of checkpoint kinase 2 in complex with inhibitor PV1115 分子名称: N-{4-[(1E)-N-1H-IMIDAZOL-2-YLETHANEHYDRAZONOYL]PHENYL}-7-NITRO-1H-INDOLE-2-CARBOXAMIDE, NITRATE ION, SERINE/THREONINE-PROTEIN KINASE CHK2 著者 Lountos, G.T, Jobson, A.G, Tropea, J.E, Self, C.R, Pommier, Y, Shoemaker, R.H, Zhang, G, Waugh, D.S. 登録日 2011-03-16 公開日 2011-11-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structural Characterization of Inhibitor Complexes with Checkpoint Kinase 2 (Chk2), a Drug Target for Cancer Therapy. J.Struct.Biol., 176, 2011
2YCS	Crystal structure of checkpoint kinase 2 in complex with PV788 分子名称: N-{4-[(1E)-N-CARBAMIMIDOYLETHANEHYDRAZONOYL]PHENYL}-1H-INDOLE-3-CARBOXAMIDE, NITRATE ION, SERINE/THREONINE-PROTEIN KINASE CHK2 著者 Lountos, G.T, Jobson, A.G, Tropea, J.E, Self, C.R, Pommier, Y, Shoemaker, R.H, Zhang, G, Waugh, D.S. 登録日 2011-03-16 公開日 2011-11-16 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structural Characterization of Inhibitor Complexes with Checkpoint Kinase 2 (Chk2), a Drug Target for Cancer Therapy. J.Struct.Biol., 176, 2011
5MWH	Crystal structure of the human BRPF1 bromodomain in complex with BZ089 分子名称: NITRATE ION, Peregrin, ~{N}-[1,4-dimethyl-7-morpholin-4-yl-2,3-bis(oxidanylidene)quinoxalin-6-yl]-4-(2-methylpropyl)benzenesulfonamide 著者 Zhu, J, Caflisch, A. 登録日 2017-01-18 公開日 2018-02-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structure-based discovery of selective BRPF1 bromodomain inhibitors. Eur J Med Chem, 155, 2018
5MWZ	Crystal structure of the human BRPF1 bromodomain in complex with BZ073 分子名称: Peregrin, ~{N}-[1,4-diethyl-2,3-bis(oxidanylidene)-7-piperidin-1-yl-quinoxalin-6-yl]-2-(4-methylpiperazin-1-yl)ethanamide 著者 Zhu, J, Caflisch, A. 登録日 2017-01-20 公開日 2018-02-14 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Structure-based discovery of selective BRPF1 bromodomain inhibitors. Eur J Med Chem, 155, 2018
5CPR	The novel SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity 分子名称: 6,7-dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine, Histone-lysine N-methyltransferase SUV420H1, S-ADENOSYLMETHIONINE, ... 著者 Jakob, C.G, Upadhyay, A.K, Sun, C. 登録日 2015-07-21 公開日 2017-01-25 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity. Nat. Chem. Biol., 13, 2017
7WME	Crystal Structure of the catalytic domain of At-HIGLE 分子名称: CALCIUM ION, Structure-specific endonuclease subunit SLX1 homolog 著者 Verma, P, Kumari, P, Negi, S, Yadav, G, Gaur, V. 登録日 2022-01-14 公開日 2022-04-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Holliday junction resolution by At-HIGLE: an SLX1 lineage endonuclease from Arabidopsis thaliana with a novel in-built regulatory mechanism. Nucleic Acids Res., 50, 2022
6FDF	Crystal structure of S. pombe Dnmt2 methyltransferase 分子名称: GLYCEROL, S-ADENOSYL-L-HOMOCYSTEINE, tRNA (cytosine(38)-C(5))-methyltransferase 著者 Johannsson, S, Neumann, P, Ficner, R. 登録日 2017-12-22 公開日 2018-06-20 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.697 Å) 主引用文献 Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine. Sci Rep, 8, 2018
5CYQ	HIV-1 reverse transcriptase complexed with 4-bromopyrazole 分子名称: 4-bromo-1H-pyrazole, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, BROMIDE ION, ... 著者 Bauman, J.D, Arnold, E. 登録日 2015-07-30 公開日 2015-12-30 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.147 Å) 主引用文献 Rapid experimental SAD phasing and hot-spot identification with halogenated fragments. IUCrJ, 3, 2016
7MPI	Stm1 bound vacant 80S structure isolated from cbf5-D95A 分子名称: 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... 著者 Rai, J, Zhao, Y, Li, H. 登録日 2021-05-04 公開日 2022-05-11 最終更新日 2022-07-20 実験手法 ELECTRON MICROSCOPY (3.05 Å) 主引用文献 CryoEM structures of pseudouridine-free ribosome suggest impacts of chemical modifications on ribosome conformations. Structure, 30, 2022
7MPJ	Stm1 bound vacant 80S structure isolated from wild-type 分子名称: 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... 著者 Rai, J, Zhao, Y, Li, H. 登録日 2021-05-04 公開日 2022-05-11 最終更新日 2023-12-13 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 CryoEM structures of pseudouridine-free ribosome suggest impacts of chemical modifications on ribosome conformations. Structure, 30, 2022
4ERZ	X-ray structure of WDR5-MLL4 Win motif peptide binary complex 分子名称: Histone-lysine N-methyltransferase MLL4, WD repeat-containing protein 5 著者 Dharmarajan, V, Lee, J.-H, Patel, A, Skalnik, D.G, Cosgrove, M.S. 登録日 2012-04-21 公開日 2012-05-30 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases. J.Biol.Chem., 287, 2012
4WW4	Double-heterohexameric rings of full-length Rvb1(ADP)/Rvb2(ADP) 分子名称: ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2 著者 Lakomek, K, Hopfner, K.-P. 登録日 2014-11-10 公開日 2015-02-18 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.94 Å) 主引用文献 Structural Basis for Dodecameric Assembly States and Conformational Plasticity of the Full-Length AAA+ ATPases Rvb1Rvb2. Structure, 23, 2015
5DDJ	Crystal structure of recombinant foot-and-mouth-disease virus O1M-S2093Y empty capsid 分子名称: Foot and mouth disease virus, VP1, VP2, ... 著者 Kotecha, A, Seago, J, Scott, K, Burman, A, Loureiro, S, Ren, J, Porta, C, Ginn, H.M, Jackson, T, Perez-Martin, E, Siebert, C.A, Paul, G, Huiskonen, J.T, Jones, I.M, Esnouf, R.M, Fry, E.E, Maree, F.F, Charleston, B, Stuart, D.I. 登録日 2015-08-25 公開日 2015-09-23 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.5 Å) 主引用文献 Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design. Nat.Struct.Mol.Biol., 22, 2015
5A9U	Structure of C1156Y Mutant Human Anaplastic Lymphoma Kinase in Complex with PF-06463922 ((10R)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile). 分子名称: (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile, ALK TYROSINE KINASE RECEPTOR 著者 McTigue, M, Deng, Y.-L, Liu, W, Brooun, A, Stewart, A. 登録日 2015-07-22 公開日 2016-06-08 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Resensitization to Crizotinib by the Lorlatinib Alk Resistance Mutation L1198F. N.Engl.J.Med., 374, 2016
6P5B	Crystal Structure of MavC in Complex with Ub-UbE2N 分子名称: MavC, Ubiquitin, Ubiquitin-conjugating enzyme E2 N 著者 Puvar, K, Iyer, S, Negron Teron, K.I, Das, C. 登録日 2019-05-30 公開日 2020-05-27 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.099 Å) 主引用文献 Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination. Nat Commun, 11, 2020
1M36	Solution Structure of a CCHC Zinc Finger from MOZ 分子名称: Monocytic leukemia zinc finger protein, ZINC ION 著者 Kwan, A.H.Y, Gell, D.A, Liew, C.K, Mackay, J.P. 登録日 2002-06-27 公開日 2004-01-27 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution Structure of a CCHC Zinc Finger from MOZ To be Published
5PWR	PanDDA analysis group deposition -- Crystal Structure of SP100 after initial refinement with no ligand modelled (structure 15) 分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Nuclear autoantigen Sp-100, ... 著者 Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. 登録日 2017-02-08 公開日 2017-03-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun, 8, 2017
5PX2	PanDDA analysis group deposition -- Crystal Structure of SP100 after initial refinement with no ligand modelled (structure 26) 分子名称: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Nuclear autoantigen Sp-100, ... 著者 Pearce, N.M, Krojer, T, Talon, R, Bradley, A.R, Fairhead, M, Sethi, R, Wright, N, MacLean, E, Collins, P, Brandao-Neto, J, Douangamath, A, Renjie, Z, Dias, A, Ng, J, Brennan, P.E, Cox, O, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. 登録日 2017-02-08 公開日 2017-03-22 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.43 Å) 主引用文献 A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density. Nat Commun, 8, 2017

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