5CYQ
HIV-1 reverse transcriptase complexed with 4-bromopyrazole
Summary for 5CYQ
Entry DOI | 10.2210/pdb5cyq/pdb |
Related | 5CW1 5CXR 5CYM |
Descriptor | HIV-1 reverse transcriptase, p66 subunit, HIV-1 reverse transcriptase, p51 subunit, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ... (7 entities in total) |
Functional Keywords | 4-bromopyrazole, phasing, influenza endonuclease, fragment screening, transferase |
Biological source | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) More |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366 |
Total number of polymer chains | 2 |
Total formula weight | 117620.78 |
Authors | Bauman, J.D.,Arnold, E. (deposition date: 2015-07-30, release date: 2015-12-30, Last modification date: 2023-09-27) |
Primary citation | Bauman, J.D.,Harrison, J.J.,Arnold, E. Rapid experimental SAD phasing and hot-spot identification with halogenated fragments. IUCrJ, 3:51-60, 2016 Cited by PubMed: 26870381DOI: 10.1107/S2052252515021259 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.147 Å) |
Structure validation
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