PDB: 8861 件ウェブページステータス検索Chemie searchBIRD

---

1M51	PEPCK complex with a GTP-competitive inhibitor 分子名称: 1,2-ETHANEDIOL, ACETATE ION, MANGANESE (II) ION, ... 著者 Foley, L.H, Wang, P, Dunten, P, Wertheimer, S.J. 登録日 2002-07-06 公開日 2003-09-30 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 X-ray Structures of two xanthine inhibitors bound to PEPCK and N-3 modifications of substituted 1,8-Dibenzylxanthines Bioorg.Med.Chem.Lett., 13, 2003
1NHX	PEPCK COMPLEX WITH A GTP-COMPETITIVE INHIBITOR 分子名称: 1,2-ETHANEDIOL, MANGANESE (II) ION, N-{4-[1-(2-FLUOROBENZYL)-3-BUTYL-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-8-YLMETHYL]-PHENYL}-ACETAMIDE, ... 著者 Foley, L.H, Wang, P, Dunten, P, Ramsey, G, Gubler, M.-L, Wertheimer, S.J. 登録日 2002-12-19 公開日 2003-09-30 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 X-RAY STRUCTURES OF TWO XANTHINE INHIBITORS BOUND TO PEPCK and N-3 modifications of substituted 1,8-Dibenzylxanthines Bioorg.Med.Chem.Lett., 13, 2003
7AH8	NF-Y bound to suramin inhibitor 分子名称: 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON IC ACID, CITRATE ANION, GLYCEROL, ... 著者 Nardone, V, Chaves-Sanjuan, A, Lapi, M, Nardini, M. 登録日 2020-09-24 公開日 2021-08-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.70001364 Å) 主引用文献 Structural Basis of Inhibition of the Pioneer Transcription Factor NF-Y by Suramin. Cells, 9, 2020
7B7S	CDK2/cyclin A2 in complex with 3H-pyrazolo[4,3-f]quinoline-based derivative HSD1368 分子名称: 7-(3-(trifluoromethyl)-1H-pyrazol-4yl)-3,8,10,11-tetrahydropyrazolo[4,3-f]thiopyrano[3,4-c]quinoline 9-oxide, Cyclin-A2, Cyclin-dependent kinase 2, ... 著者 Djukic, S, Skerlova, J, Rezacova, P. 登録日 2020-12-11 公開日 2021-08-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.54 Å) 主引用文献 3 H -Pyrazolo[4,3- f ]quinoline-Based Kinase Inhibitors Inhibit the Proliferation of Acute Myeloid Leukemia Cells In Vivo. J.Med.Chem., 64, 2021
8OK2	Bipartite interaction of TOPBP1 with the GINS complex 分子名称: DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, DNA replication complex GINS protein PSF3, ... 著者 Day, M, Oliver, A.W, Pearl, L.H. 登録日 2023-03-26 公開日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 TopBP1 utilises a bipartite GINS binding mode to support genome replication. Nat Commun, 15, 2024
1G3N	STRUCTURE OF A P18(INK4C)-CDK6-K-CYCLIN TERNARY COMPLEX 分子名称: CYCLIN-DEPENDENT KINASE 6, CYCLIN-DEPENDENT KINASE 6 INHIBITOR, V-CYCLIN 著者 Jeffrey, P.D, Tong, L, Pavletich, N.P. 登録日 2000-10-24 公開日 2001-01-10 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors. Genes Dev., 14, 2000
1DM2	HUMAN CYCLIN-DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR HYMENIALDISINE 分子名称: 1,2-ETHANEDIOL, 4-(5-AMINO-4-OXO-4H-PYRAZOL-3-YL)-2-BROMO-4,5,6,7-TETRAHYDRO-3AH-PYRROLO[2,3-C]AZEPIN-8-ONE, CYCLIN-DEPENDENT KINASE 2 著者 Thunnissen, A.M, Kim, S.-H. 登録日 1999-12-13 公開日 2000-05-31 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent. Chem.Biol., 7, 2000
2QCS	A complex structure between the Catalytic and Regulatory subunit of Protein Kinase A that represents the inhibited state 分子名称: ACETATE ION, GLYCEROL, MANGANESE (II) ION, ... 著者 Kim, C, Cheng, C.Y, Saldanha, A.S, Taylor, S.S. 登録日 2007-06-19 公開日 2007-11-06 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation. Cell(Cambridge,Mass.), 130, 2007
2XGX	Crystal structure of transcription factor NtcA from Synechococcus elongatus (mercury derivative) 分子名称: 2-OXOGLUTARIC ACID, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, GLOBAL NITROGEN REGULATOR, ... 著者 Llacer, J.L, Castells, M.A, Rubio, V. 登録日 2010-06-08 公開日 2010-08-18 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structural Basis for the Regulation of Ntca-Dependent Transcription by Proteins Pipx and Pii. Proc.Natl.Acad.Sci.USA, 107, 2010
1CQT	CRYSTAL STRUCTURE OF A TERNARY COMPLEX CONTAINING AN OCA-B PEPTIDE, THE OCT-1 POU DOMAIN, AND AN OCTAMER ELEMENT 分子名称: DNA (5'-D(*AP*CP*CP*TP*TP*AP*TP*TP*TP*GP*CP*AP*TP*AP*C)-3'), DNA (5'-D(*TP*GP*TP*AP*TP*GP*CP*AP*AP*AP*TP*AP*AP*GP*G)-3'), POU DOMAIN, ... 著者 Chasman, D.I, Cepek, K, Sharp, P.A, Pabo, C.O. 登録日 1999-08-11 公開日 1999-11-15 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface. Genes Dev., 13, 1999
1W8C	CO-CRYSTAL STRUCTURE OF 6-CYCLOHEXYLMETHOXY-8-ISOPROPYL-9H-PURIN-2- YLAMINE AND MONOMERIC CDK2 分子名称: 6-(CYCLOHEXYLMETHOXY)-8-ISOPROPYL-9H-PURIN-2-AMINE, CELL DIVISION PROTEIN KINASE 2 著者 Pratt, D.J, Endicott, J.A, Noble, M.E.M. 登録日 2004-09-20 公開日 2006-08-30 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 8-Substituted O6-Cyclohexylmethylguanine Cdk2 Inhibitors; Using Structure-Based Inhibitor Design to Optimise an Alternative Binding Mode. J.Med.Chem., 57, 2014
5V9H	Structure of the H477R variant of rat cytosolic PEPCK in complex with phosphoglycolate and GDP. 分子名称: 2-PHOSPHOGLYCOLIC ACID, GUANOSINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ... 著者 Holyoak, T, Cui, D.S. 登録日 2017-03-23 公開日 2017-04-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Asymmetric Anchoring Is Required for Efficient Omega-Loop Opening and Closing in Cytosolic Phosphoenolpyruvate Carboxykinase. Biochemistry, 56, 2017
5V95	Structure of the H477R variant of rat cytosolic PEPCK in complex with manganese. 分子名称: MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, cytosolic [GTP], ... 著者 Holyoak, T, Cui, D.S. 登録日 2017-03-23 公開日 2017-04-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Asymmetric Anchoring Is Required for Efficient Omega-Loop Opening and Closing in Cytosolic Phosphoenolpyruvate Carboxykinase. Biochemistry, 56, 2017
5V9F	Structure of the H477R variant of rat cytosolic PEPCK in complex with beta sulfopyruvate and GTP. 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, ... 著者 Holyoak, T, Cui, D.S. 登録日 2017-03-23 公開日 2017-04-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Asymmetric Anchoring Is Required for Efficient Omega-Loop Opening and Closing in Cytosolic Phosphoenolpyruvate Carboxykinase. Biochemistry, 56, 2017
5V97	Structure of the H477R variant of rat cytosolic PEPCK in complex with GTP. 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, Phosphoenolpyruvate carboxykinase, ... 著者 Holyoak, T, Cui, D.S. 登録日 2017-03-23 公開日 2017-04-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Asymmetric Anchoring Is Required for Efficient Omega-Loop Opening and Closing in Cytosolic Phosphoenolpyruvate Carboxykinase. Biochemistry, 56, 2017
3HH2	Crystal structure of the myostatin:follistatin 288 complex 分子名称: CITRIC ACID, Follistatin, Growth/differentiation factor 8, ... 著者 Cash, J.N, Thompson, T.B. 登録日 2009-05-14 公開日 2009-08-04 最終更新日 2017-11-01 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding Embo J., 28, 2009
6GVA	CDK2/cyclin A2 in complex with pyrazolo[4,3-d]pyrimidine inhibitor LGR4455 分子名称: 1,2-ETHANEDIOL, 5-(2-azanylethylsulfanyl)-3-propan-2-yl-~{N}-[(4-pyridin-2-ylphenyl)methyl]-2~{H}-pyrazolo[4,3-d]pyrimidin-7-amine, BROMIDE ION, ... 著者 Skerlova, J, Rezacova, P. 登録日 2018-06-20 公開日 2019-05-01 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 3,5,7-Substituted Pyrazolo[4,3- d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models. J.Med.Chem., 62, 2019
5V9G	Structure of the H477R variant of rat cytosolic PEPCK in complex with oxalate and GTP. 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, OXALATE ION, ... 著者 Holyoak, T, Cui, D.S. 登録日 2017-03-23 公開日 2017-04-12 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Asymmetric Anchoring Is Required for Efficient Omega-Loop Opening and Closing in Cytosolic Phosphoenolpyruvate Carboxykinase. Biochemistry, 56, 2017
3MZ4	Crystal structure of D101L Mn2+ HDAC8 complexed with M344 分子名称: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, GLYCEROL, Histone deacetylase 8, ... 著者 Dowling, D.P, Gattis, S.G, Fierke, C.A, Christianson, D.W. 登録日 2010-05-11 公開日 2010-06-23 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.845 Å) 主引用文献 Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function. Biochemistry, 49, 2010
3HJH	A rigid N-terminal clamp restrains the motor domains of the bacterial transcription-repair coupling factor 分子名称: COBALT (II) ION, Transcription-repair-coupling factor 著者 Murphy, M, Gong, P, Ralto, K, Manelyte, L, Savery, N, Theis, K. 登録日 2009-05-21 公開日 2009-10-20 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 An N-terminal clamp restrains the motor domains of the bacterial transcription-repair coupling factor Mfd. Nucleic Acids Res., 37, 2009
3MOE	The structure of rat cytosolic PEPCK mutant A467G in complex with Beta-Sulfopyruvate and GTP 分子名称: 1,2-ETHANEDIOL, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... 著者 Johnson, T.A, Holyoak, T. 登録日 2010-04-22 公開日 2010-06-02 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Increasing the conformational entropy of the Omega-loop lid domain in phosphoenolpyruvate carboxykinase impairs catalysis and decreases catalytic fidelity . Biochemistry, 49, 2010
3MOF	The structure of rat cytosolic PEPCK mutant A467G in complex with oxalate and GTP 分子名称: 1,2-ETHANEDIOL, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ... 著者 Johnson, T.A, Holyoak, T. 登録日 2010-04-22 公開日 2010-06-02 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Increasing the conformational entropy of the Omega-loop lid domain in phosphoenolpyruvate carboxykinase impairs catalysis and decreases catalytic fidelity . Biochemistry, 49, 2010
4CFN	Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors. 分子名称: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 6-(cyclohexylmethoxy)-8-(trifluoromethyl)-9H-purin-2-amine, CYCLIN-A2, ... 著者 Carbain, B, Paterson, D.J, Anscombe, E, Campbell, A, Cano, C, Echalier, A, Endicott, J, Golding, B.T, Haggerty, K, Hardcastle, I.R, Jewsbury, P, Newell, D.R, Noble, M.E.M, Roche, C, Wang, L.Z, Griffin, R. 登録日 2013-11-19 公開日 2013-12-18 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 8-Substituted O6-Cyclohexylmethylguanine Cdk2 Inhibitors; Using Structure-Based Inhibitor Design to Optimise an Alternative Binding Mode. J.Med.Chem., 57, 2014
4CFV	Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors. 分子名称: 3-[2-amino-6-(cyclohexylmethoxy)-7H-purin-8-yl]-2-methylphenol, CYCLIN-A2, CYCLIN-DEPENDENT KINASE 2, ... 著者 Carbain, B, Paterson, D.J, Anscombe, E, Campbell, A, Cano, C, Echalier, A, Endicott, J, Golding, B.T, Haggerty, K, Hardcastle, I.R, Jewsbury, P, Newell, D.R, Noble, M.E.M, Roche, C, Wang, L.Z, Griffin, R. 登録日 2013-11-19 公開日 2014-12-10 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 8-Substituted O6-Cyclohexylmethylguanine Cdk2 Inhibitors; Using Structure-Based Inhibitor Design to Optimise an Alternative Binding Mode. J.Med.Chem., 57, 2014
4CFM	Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors. 分子名称: 6-(cyclohexylmethoxy)-8-(2-methylphenyl)-9H-purin-2-amine, CYCLIN-A2, CYCLIN-DEPENDENT KINASE 2 著者 Carbain, B, Paterson, D.J, Anscombe, E, Campbell, A, Cano, C, Echalier, A, Endicott, J, Golding, B.T, Haggerty, K, Hardcastle, I.R, Jewsbury, P, Newell, D.R, Noble, M.E.M, Roche, C, Wang, L.Z, Griffin, R. 登録日 2013-11-18 公開日 2014-12-10 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 8-Substituted O6-Cyclohexylmethylguanine Cdk2 Inhibitors; Using Structure-Based Inhibitor Design to Optimise an Alternative Binding Mode. J.Med.Chem., 57, 2014

<113114115116117118119120121122123124125126127128>