6GVA

CDK2/cyclin A2 in complex with pyrazolo[4,3-d]pyrimidine inhibitor LGR4455

Summary for 6GVA

• Entry DOI: 10.2210/pdb6gva/pdb
• Descriptor: Cyclin-dependent kinase 2, Cyclin-A2, 5-(2-azanylethylsulfanyl)-3-propan-2-yl-~{N}-[(4-pyridin-2-ylphenyl)methyl]-2~{H}-pyrazolo[4,3-d]pyrimidin-7-amine, ... (10 entities in total)
• Functional Keywords: cyclin-dependent kinase, pyrazolo[4, 3-d]pyrimidine, cell cycle
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 64941.51

Authors

Skerlova, J.,Rezacova, P. (deposition date: 2018-06-20, release date: 2019-05-01, Last modification date: 2024-01-17)

• Primary citation: Jorda, R.,Havlicek, L.,Sturc, A.,Tuskova, D.,Daumova, L.,Alam, M.,Skerlova, J.,Nekardova, M.,Perina, M.,Pospisil, T.,Siroka, J.,Urbanek, L.,Pachl, P.,Rezacova, P.,Strnad, M.,Klener, P.,Krystof, V.; 3,5,7-Substituted Pyrazolo[4,3- d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models.; J.Med.Chem., 62:4606-4623, 2019; PubMed: 30943029; DOI: 10.1021/acs.jmedchem.9b00189

Experimental method

X-RAY DIFFRACTION (2.15 Å)