6GVA
CDK2/cyclin A2 in complex with pyrazolo[4,3-d]pyrimidine inhibitor LGR4455
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclin-dependent kinase 2 | polymer | 299 | 34143.5 | 1 | UniProt (P24941) Pfam (PF00069) | Homo sapiens (Human) | Cell division protein kinase 2,p33 protein kinase |
| 2 | B (B) | Cyclin-A2 | polymer | 258 | 29624.3 | 1 | UniProt (P20248) Pfam (PF00134) Pfam (PF02984) | Homo sapiens (Human) | Cyclin-A,Cyclin A |
| 3 | C (A) | 5-(2-azanylethylsulfanyl)-3-propan-2-yl-~{N}-[(4-pyridin-2-ylphenyl)methyl]-2~{H}-pyrazolo[4,3-d]pyrimidin-7-amine | non-polymer | 419.5 | 1 | Chemie (FCQ) | |||
| 4 | D, E, I (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 5 | F (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | G (A) | BROMIDE ION | non-polymer | 79.9 | 1 | Chemie (BR) | |||
| 7 | H (B) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 8 | J (B) | MONOTHIOGLYCEROL | non-polymer | 108.2 | 1 | Chemie (SGM) | |||
| 9 | K (B) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 1 | Chemie (PGE) | |||
| 10 | L, M (A, B) | water | water | 18.0 | 160 | Chemie (HOH) |
Sequence modifications
A: 1 - 298 (UniProt: P24941)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 63767.8 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1173.7 | |
| All* | Total formula weight | 64941.5 |
