8DTB
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8DRP
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8DJ1
| Crystal structure of NavAb V126T as a basis for the human Nav1.7 Inherited Erythromelalgia S241T mutation | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Ion transport protein | 著者 | Wisedchaisri, G, Gamal El-Din, T.M, Zheng, N, Catterall, W.A. | 登録日 | 2022-06-29 | 公開日 | 2023-04-12 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na V 1.7. Proc.Natl.Acad.Sci.USA, 120, 2023
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8DJ0
| Crystal structure of NavAb L123T as a basis for the human Nav1.7 Inherited Erythromelalgia I848T mutation | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Ion transport protein | 著者 | Wisedchaisri, G, Gamal El-Din, T.M, Zheng, N, Catterall, W.A. | 登録日 | 2022-06-29 | 公開日 | 2023-04-12 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na V 1.7. Proc.Natl.Acad.Sci.USA, 120, 2023
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8DIZ
| Crystal structure of NavAb I119T as a basis for the human Nav1.7 Inherited Erythromelalgia I234T mutation | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Ion transport protein | 著者 | Wisedchaisri, G, Gamal El-Din, T.M, Zheng, N, Catterall, W.A. | 登録日 | 2022-06-29 | 公開日 | 2023-04-12 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structural basis for severe pain caused by mutations in the S4-S5 linkers of voltage-gated sodium channel Na V 1.7. Proc.Natl.Acad.Sci.USA, 120, 2023
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8DIY
| Crystal structure of NavAb L101S as a basis for the human Nav1.7 Inherited Erythromelalgia F216S mutation | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Ion transport protein | 著者 | Wisedchaisri, G, Gamal El-Din, T.M, Zheng, N, Catterall, W.A. | 登録日 | 2022-06-29 | 公開日 | 2023-10-25 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7. J.Gen.Physiol., 155, 2023
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8DIX
| Structure of NavAb L98R as a basis for the human Nav1.7 Inherited Erythromelalgia L823R mutation | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Ion transport protein | 著者 | Wisedchaisri, G, Gamal El-Din, T.M, Zheng, N, Catterall, W.A. | 登録日 | 2022-06-29 | 公開日 | 2023-10-25 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7. J.Gen.Physiol., 155, 2023
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8DIW
| Crystal structure of NavAb E96P as a basis for the human Nav1.7 Inherited Erythromelalgia S211P mutation | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Ion transport protein | 著者 | Wisedchaisri, G, Gamal El-Din, T.M, Zheng, N, Catterall, W.A. | 登録日 | 2022-06-29 | 公開日 | 2023-10-25 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | 主引用文献 | Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7. J.Gen.Physiol., 155, 2023
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8DIV
| Crystal structure of NavAb I22V as a basis for the human Nav1.7 Inherited Erythromelalgia I136V mutation | 分子名称: | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, Ion transport protein, ... | 著者 | Wisedchaisri, G, Gamal El-Din, T.M, Powell, N.M, Zheng, N, Catterall, W.A. | 登録日 | 2022-06-29 | 公開日 | 2023-10-25 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | 主引用文献 | Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7. J.Gen.Physiol., 155, 2023
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8DFL
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8DDX
| cryo-EM structure of TRPM3 ion channel in complex with Gbg in the presence of PIP2, tethered by ALFA-nanobody | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Zhao, C, MacKinnon, R. | 登録日 | 2022-06-19 | 公開日 | 2022-11-02 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural and functional analyses of a GPCR-inhibited ion channel TRPM3. Neuron, 111, 2023
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8DDW
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8DDV
| Cryo-EM structure of TRPM3 ion channel in the presence of PIP2, state4 | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, SODIUM ION, ... | 著者 | Zhao, C, MacKinnon, R. | 登録日 | 2022-06-19 | 公開日 | 2022-11-02 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural and functional analyses of a GPCR-inhibited ion channel TRPM3. Neuron, 111, 2023
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8DDU
| cryo-EM structure of TRPM3 ion channel in the presence of PIP2, state3 | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, SODIUM ION, ... | 著者 | Zhao, C, MacKinnon, R. | 登録日 | 2022-06-19 | 公開日 | 2022-11-02 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural and functional analyses of a GPCR-inhibited ion channel TRPM3. Neuron, 111, 2023
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8DDT
| cryo-EM structure of TRPM3 ion channel in the presence of PIP2, state2 | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, SODIUM ION, ... | 著者 | Zhao, C, MacKinnon, R. | 登録日 | 2022-06-18 | 公開日 | 2022-11-02 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural and functional analyses of a GPCR-inhibited ion channel TRPM3. Neuron, 111, 2023
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8DDS
| cryo-EM structure of TRPM3 ion channel in the presence of PIP2, state1 | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, SODIUM ION, ... | 著者 | Zhao, C, MacKinnon, R. | 登録日 | 2022-06-18 | 公開日 | 2022-11-02 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural and functional analyses of a GPCR-inhibited ion channel TRPM3. Neuron, 111, 2023
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8DDR
| cryo-EM structure of TRPM3 ion channel in the absence of PIP2 | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, SODIUM ION, ... | 著者 | Zhao, C, MacKinnon, R. | 登録日 | 2022-06-18 | 公開日 | 2022-11-02 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural and functional analyses of a GPCR-inhibited ion channel TRPM3. Neuron, 111, 2023
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8DDQ
| cryo-EM structure of TRPM3 ion channel in the presence of soluble Gbg, focused on channel | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, SODIUM ION, ... | 著者 | Zhao, C, MacKinnon, R. | 登録日 | 2022-06-18 | 公開日 | 2022-11-02 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural and functional analyses of a GPCR-inhibited ion channel TRPM3. Neuron, 111, 2023
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8BX7
| Structure of the rod CNG channel bound to calmodulin | 分子名称: | Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1, calmodulin-1 | 著者 | Marino, J. | 登録日 | 2022-12-08 | 公開日 | 2023-04-12 | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | 主引用文献 | Structural basis of calmodulin modulation of the rod cyclic nucleotide-gated channel. Proc.Natl.Acad.Sci.USA, 120, 2023
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8BDC
| Human apo TRPM8 in a closed state (composite map) | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL HEMISUCCINATE, SODIUM ION, ... | 著者 | Palchevskyi, S, Czarnocki-Cieciura, M, Vistoli, G, Gervasoni, S, Nowak, E, Beccari, A.R, Nowotny, M, Talarico, C. | 登録日 | 2022-10-19 | 公開日 | 2023-11-01 | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | 主引用文献 | Structure of human TRPM8 channel. Commun Biol, 6, 2023
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7ZJI
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7ZJH
| TRPV2-C16+Pro-2 | 分子名称: | Transient receptor potential cation channel subfamily V member 2 | 著者 | Zhang, L, Gourdon, P, Zygmunt, P.M. | 登録日 | 2022-04-11 | 公開日 | 2023-01-18 | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | 主引用文献 | Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function. Nat Commun, 13, 2022
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7ZJG
| Probenecid | 分子名称: | Transient receptor potential cation channel subfamily V member 2 | 著者 | Zhang, L, Gourdon, P, Zygmunt, P.M. | 登録日 | 2022-04-11 | 公開日 | 2023-01-18 | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | 主引用文献 | Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function. Nat Commun, 13, 2022
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7ZJE
| C16-2 | 分子名称: | Transient receptor potential cation channel subfamily V member 2,Enhanced green fluorescent protein | 著者 | Zhang, L, Gourdon, P, Zygmunt, P.M. | 登録日 | 2022-04-10 | 公開日 | 2023-01-18 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function. Nat Commun, 13, 2022
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7ZJD
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