8DIY

Crystal structure of NavAb L101S as a basis for the human Nav1.7 Inherited Erythromelalgia F216S mutation

Summary for 8DIY

Entry DOI	10.2210/pdb8diy/pdb
Descriptor	Ion transport protein, 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ... (4 entities in total)
Functional Keywords	voltage-gated sodium channel ion transport protein, membrane protein
Biological source	Aliarcobacter butzleri RM4018
Total number of polymer chains	1
Total formula weight	34387.67
Authors	Wisedchaisri, G.,Gamal El-Din, T.M.,Zheng, N.,Catterall, W.A. (deposition date: 2022-06-29, release date: 2023-10-25, Last modification date: 2023-11-15)
Primary citation	Wisedchaisri, G.,Gamal El-Din, T.M.,Powell, N.M.,Zheng, N.,Catterall, W.A. Structural basis for severe pain caused by mutations in the voltage sensors of sodium channel NaV1.7. J.Gen.Physiol., 155:-, 2023 Cited by PubMed: 37903281 DOI: 10.1085/jgp.202313450 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation