PDB: 1500 件ウェブページステータス検索Chemie searchBIRD

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6S8Q	Human Brr2 Helicase Region in complex with C-tail deleted Jab1 分子名称: Pre-mRNA-processing-splicing factor 8, SULFATE ION, U5 small nuclear ribonucleoprotein 200 kDa helicase 著者 Santos, K.F, Vester, K, Wahl, M.C. 登録日 2019-07-10 公開日 2020-01-22 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (2.391 Å) 主引用文献 The inactive C-terminal cassette of the dual-cassette RNA helicase BRR2 both stimulates and inhibits the activity of the N-terminal helicase unit. J.Biol.Chem., 295, 2020
6S9I	Human Brr2 Helicase Region D534C/N1866C in complex with C-tail deleted Jab1 分子名称: Pre-mRNA-processing-splicing factor 8, U5 small nuclear ribonucleoprotein 200 kDa helicase 著者 Vester, K, Santos, K.F, Wahl, M.C. 登録日 2019-07-13 公開日 2020-01-22 最終更新日 2020-02-26 実験手法 X-RAY DIFFRACTION (2.598 Å) 主引用文献 The inactive C-terminal cassette of the dual-cassette RNA helicase BRR2 both stimulates and inhibits the activity of the N-terminal helicase unit. J.Biol.Chem., 295, 2020
2VY5	U11-48K CHHC Zn-finger protein domain 分子名称: U11/U12 SMALL NUCLEAR RIBONUCLEOPROTEIN 48 KDA PROTEIN, ZINC ION 著者 Tidow, H, Andreeva, A, Rutherford, T.J, Fersht, A.R. 登録日 2008-07-18 公開日 2009-02-17 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Solution structure of the U11-48K CHHC zinc-finger domain that specifically binds the 5' splice site of U12-type introns. Structure, 17, 2009
3EGN	C-terminal RNA Recognition Motif of the U11/U12 65K Protein 分子名称: RNA-binding protein 40 著者 Netter, C, Wahl, M.C. 登録日 2008-09-11 公開日 2009-06-09 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Functional stabilization of an RNA recognition motif by a noncanonical N-terminal expansion Rna, 15, 2009
6V0N	PRMT5 bound to PBM peptide from Riok1 分子名称: Methylosome protein 50, Protein arginine N-methyltransferase 5, Riok1 PBM peptide, ... 著者 McMIllan, B.J, Raymond, D.D. 登録日 2019-11-19 公開日 2020-08-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Molecular basis for substrate recruitment to the PRMT5 methylosome. Mol.Cell, 81, 2021
6V0O	PRMT5 bound to the PBM peptide from pICln 分子名称: ACETYL GROUP, Methylosome protein 50, PBM peptide, ... 著者 McMillan, B.J, Raymond, D.D. 登録日 2019-11-19 公開日 2020-08-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.86 Å) 主引用文献 Molecular basis for substrate recruitment to the PRMT5 methylosome. Mol.Cell, 81, 2021
3SBS	Crystal structure of Aar2 protein 分子名称: A1 cistron-splicing factor AAR2 著者 Weber, G, Santos, K.F, Holton, N, Wahl, M.C. 登録日 2011-06-06 公開日 2012-04-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Mechanism for Aar2p function as a U5 snRNP assembly factor. Genes Dev., 25, 2011
4PYU	The conserved ubiquitin-like protein hub1 plays a critical role in splicing in human cells 分子名称: U4/U6.U5 tri-snRNP-associated protein 1, Ubiquitin-like protein 5 著者 Ammon, T, Mishra, S.K, Kowalska, K, Popowicz, G.M, Holak, T.A, Jentsch, S. 登録日 2014-03-28 公開日 2014-07-16 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 The conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells. J Mol Cell Biol, 6, 2014
5SYB	Crystal structure of human PHF5A 分子名称: 1,2-ETHANEDIOL, PHD finger-like domain-containing protein 5A, ZINC ION 著者 Tsai, J.H.C, Teng, T, Zhu, P, Fekkes, P, Larsen, N.A. 登録日 2016-08-10 公開日 2016-09-07 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.82 Å) 主引用文献 Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex. Nat Commun, 8, 2017
7OS1	Cryo-EM structure of Brr2 in complex with Fbp21 分子名称: U5 small nuclear ribonucleoprotein 200 kDa helicase, WW domain-binding protein 4 著者 Bergfort, A, Hilal, T, Weber, G, Wahl, M.C. 登録日 2021-06-07 公開日 2022-02-23 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 The intrinsically disordered TSSC4 protein acts as a helicase inhibitor, placeholder and multi-interaction coordinator during snRNP assembly and recycling. Nucleic Acids Res., 50, 2022
6ZM2	Crystal structure of the DEAH-box ATPase Prp2 in complex with ADP-BeF3 and ssRNA 分子名称: 1,2-ETHANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Hamann, F, Ficner, R. 登録日 2020-07-01 公開日 2021-04-21 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The structure of Prp2 bound to RNA and ADP-BeF 3 - reveals structural features important for RNA unwinding by DEAH-box ATPases. Acta Crystallogr D Struct Biol, 77, 2021
4JK9	Open and closed forms of wild-type human PRP8 RNase H-like domain with bound Co ion 分子名称: CHLORIDE ION, COBALT (II) ION, GLYCEROL, ... 著者 Schellenberg, M.J, Wu, T, Ritchie, D.B, Atta, K.A, MacMillan, A.M. 登録日 2013-03-09 公開日 2013-05-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Nat.Struct.Mol.Biol., 20, 2013
4JKH	Open and closed forms of D1781E human PRP8 RNase H-like domain with bound Mg ion 分子名称: CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ... 著者 Schellenberg, M.J, Wu, T, Ritchie, D.B, Atta, K.A, MacMillan, A.M. 登録日 2013-03-09 公開日 2013-05-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Nat.Struct.Mol.Biol., 20, 2013
4JKC	Open and closed forms of T1800E human PRP8 RNase H-like domain with bound Mg ion 分子名称: CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ... 著者 Schellenberg, M.J, Wu, T, Ritchie, D.B, Atta, K.A, MacMillan, A.M. 登録日 2013-03-09 公開日 2013-05-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Nat.Struct.Mol.Biol., 20, 2013
4JK7	Open and closed forms of wild-type human PRP8 RNase H-like domain with bound Mg ion 分子名称: CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ... 著者 Schellenberg, M.J, Wu, T, Ritchie, D.B, Atta, K, MacMillan, A.M. 登録日 2013-03-09 公開日 2013-05-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Nat.Struct.Mol.Biol., 20, 2013
4JKD	Open and closed forms of I1790Y human PRP8 RNase H-like domain with bound Mg ion 分子名称: CHLORIDE ION, MAGNESIUM ION, Pre-mRNA-processing-splicing factor 8 著者 Schellenberg, M.J, Wu, T, Ritchie, D.B, Atta, K.A, MacMillan, A.M. 登録日 2013-03-09 公開日 2013-05-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Nat.Struct.Mol.Biol., 20, 2013
4JK8	Open and closed forms of R1865A human PRP8 RNase H-like domain with bound Mg ion 分子名称: CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ... 著者 Schellenberg, M.J, Wu, T, Ritchie, D.B, Atta, K.A, MacMillan, A.M. 登録日 2013-03-09 公開日 2013-05-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Nat.Struct.Mol.Biol., 20, 2013
4JKF	Open and closed forms of T1791P+R1865A human PRP8 RNase H-like domain with bound Mg ion 分子名称: MAGNESIUM ION, Pre-mRNA-processing-splicing factor 8 著者 Schellenberg, M.J, Wu, T, Ritchie, D.B, Atta, K.A, MacMillan, A.M. 登録日 2013-03-09 公開日 2013-05-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Nat.Struct.Mol.Biol., 20, 2013
1XTK	structure of DECD to DEAD mutation of human UAP56 分子名称: BETA-MERCAPTOETHANOL, Probable ATP-dependent RNA helicase p47 著者 Shi, H, Cordin, O, Minder, C.M, Linder, P, Xu, R.M. 登録日 2004-10-22 公開日 2004-12-14 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of the human ATP-dependent splicing and export factor UAP56 Proc.Natl.Acad.Sci.USA, 101, 2004
4JKE	Open and closed forms of T1789P human PRP8 RNase H-like domain with bound Mg ion 分子名称: MAGNESIUM ION, Pre-mRNA-processing-splicing factor 8 著者 Schellenberg, M.J, Wu, T, Ritchie, D.B, Atta, K.A, MacMillan, A.M. 登録日 2013-03-09 公開日 2013-05-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Nat.Struct.Mol.Biol., 20, 2013
4JKA	Open and closed forms of R1865A human PRP8 RNase H-like domain with bound Co ion 分子名称: CHLORIDE ION, COBALT (II) ION, Pre-mRNA-processing-splicing factor 8 著者 Schellenberg, M.J, Wu, T, Ritchie, D.B, Atta, K.A, MacMillan, A.M. 登録日 2013-03-09 公開日 2013-05-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.32 Å) 主引用文献 A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Nat.Struct.Mol.Biol., 20, 2013
4JKG	Open and closed forms of mixed T1789P+R1865A and R1865A human PRP8 RNase H-like domain with bound Mg ion 分子名称: MAGNESIUM ION, Pre-mRNA-processing-splicing factor 8 著者 Schellenberg, M.J, Wu, T, Ritchie, D.B, Atta, K.A, MacMillan, A.M. 登録日 2013-03-09 公開日 2013-05-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Nat.Struct.Mol.Biol., 20, 2013
4ILG	Crystal structure of Aar2p in complex with the Prp8p RNaseH and Jab1/MPN domains 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, A1 cistron-splicing factor AAR2, Pre-mRNA-splicing factor 8 著者 Weber, G, Heroven, A.C, Santos, K.F, Wahl, M.C. 登録日 2012-12-31 公開日 2013-03-13 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural basis for dual roles of Aar2p in U5 snRNP assembly. Genes Dev., 27, 2013
4JKB	Open and closed forms of V1788D human PRP8 RNase H-like domain with bound Mg ion 分子名称: CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ... 著者 Schellenberg, M.J, Wu, T, Ritchie, D.B, Atta, K.A, MacMillan, A.M. 登録日 2013-03-09 公開日 2013-05-22 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Nat.Struct.Mol.Biol., 20, 2013
2DT7	Solution structure of the second SURP domain of human splicing factor SF3a120 in complex with a fragment of human splicing factor SF3a60 分子名称: Splicing factor 3 subunit 1, Splicing factor 3A subunit 3 著者 He, F, Kuwasako, K, Inoue, M, Guntert, P, Muto, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-07-11 公開日 2006-12-26 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structures of the SURP domains and the subunit-assembly mechanism within the splicing factor SF3a complex in 17S U2 snRNP Structure, 14, 2006

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