PDB: 221716 件ウェブページステータス検索Chemie searchBIRD

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8TN6	De novo designed protein binds poly ADP ribose polymerase inhibitors (PARPi) - holo rucaparib 分子名称: De novo designed protein, Rucaparib 著者 Lu, L, DeGrado, W.F. 登録日 2023-08-01 公開日 2024-04-24 実験手法 X-RAY DIFFRACTION (1.36 Å) 主引用文献 De novo design of drug-binding proteins with predictable binding energy and specificity. Science, 384, 2024
8TN3	Structure of S. hygroscopicus aminotransferase MppQ complexed with pyridoxamine 5'-phosphate (PMP) 分子名称: 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, PLP-dependent aminotransferase MppQ 著者 Silvaggi, N.R, Vuksanovic, N. 登録日 2023-08-01 公開日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Structural and Biochemical Characterization of MppQ, an L-Enduracididine Biosynthetic Enzyme from Streptomyces hygroscopicus. Biochemistry, 62, 2023
8TN2	Structure of S. hygroscopicus aminotransferase MppQ complexed with pyridoxal-5'-phosphate (PLP) 分子名称: PLP-dependent aminotransferase MppQ 著者 Silvaggi, N.R, Vuksanovic, N. 登録日 2023-08-01 公開日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structural and Biochemical Characterization of MppQ, an L-Enduracididine Biosynthetic Enzyme from Streptomyces hygroscopicus. Biochemistry, 62, 2023
8TN1	De novo designed protein binds poly ADP ribose polymerase inhibitors (PARPi) - apo 分子名称: De novo designed 4 helix bundles, SULFATE ION 著者 Lu, L, DeGrado, W.F. 登録日 2023-08-01 公開日 2024-04-24 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 De novo design of drug-binding proteins with predictable binding energy and specificity. Science, 384, 2024
8TN0	Crystal structure of KPC-44 carbapenemase w/o cryoprotectant 分子名称: SULFATE ION, beta-lactamase 著者 Sun, Z, Palzkill, T, Hu, L, Lin, H, Sankaran, B, Wang, J, Prasad, B. 登録日 2023-07-31 公開日 2023-12-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.31 Å) 主引用文献 Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resistance by altering the conformation of active-site loops. J.Biol.Chem., 300, 2023
8TMT	Crystal structure of KPC-44 carbapenemase in complex with vaborbactam 分子名称: 1,2-ETHANEDIOL, GLYCEROL, LITHIUM ION, ... 著者 Sun, Z, Palzkill, T, Hu, L, Neetu, N, Lin, H, Sankaran, B, Wang, J, Prasad, B. 登録日 2023-07-30 公開日 2023-12-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resistance by altering the conformation of active-site loops. J.Biol.Chem., 300, 2023
8TMS	Crystal structure of bacterial pectin methylesterase PmeC2 from rumen Butyrivibrio 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Pectinesterase 著者 Carbone, V, Reilly, K, Sang, C, Schofield, L, Ronimus, R, Kelly, W.J, Attwood, G.T, Palevich, N. 登録日 2023-07-30 公開日 2023-08-16 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal Structures of Bacterial Pectin Methylesterases Pme8A and PmeC2 from Rumen Butyrivibrio . Int J Mol Sci, 24, 2023
8TMR	Crystal structure of KPC-44 carbapenemase complexed with avibactam 分子名称: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, 1,2-ETHANEDIOL, PHOSPHATE ION, ... 著者 Sun, Z, Palzkill, T, Hu, L, Lin, H, Sankaran, B, Wang, J, Prasad, B. 登録日 2023-07-30 公開日 2023-12-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.37 Å) 主引用文献 Klebsiella pneumoniae carbapenemase variant 44 acquires ceftazidime-avibactam resistance by altering the conformation of active-site loops. J.Biol.Chem., 300, 2023
8TMA	Antibody N3-1 bound to RBD in the up conformation 分子名称: N3-1 Fab heavy chain, N3-1 Fab light chain, Spike glycoprotein 著者 Hsieh, C.-L, McLellan, J.S. 登録日 2023-07-29 公開日 2024-01-17 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 SARS-COV-2 Omicron variants conformationally escape a rare quaternary antibody binding mode. Commun Biol, 6, 2023
8TM7	Human NAMPT in complex with substrate NAM and small molecule activator NP-A3 分子名称: CHLORIDE ION, GLYCEROL, N-{2-[(4R)-2,2-dimethyl-4-(propan-2-yl)oxan-4-yl]ethyl}-N-[(4-methoxyphenyl)methyl]furan-2-carboxamide, ... 著者 Ratia, K.M, Thatcher, G.R. 登録日 2023-07-28 公開日 2024-06-12 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Nicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress. Acs Med.Chem.Lett., 15, 2024
8TM2	Preclinical Characterization of Pan-NKG2D Ligand-Binding NKG2D Receptor Decoys 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... 著者 Rupert, P.B, Strong, R. 登録日 2023-07-27 公開日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Preclinical characterization of Pan-NKG2D ligand-binding NKG2D receptor decoys. Heliyon, 10, 2024
8TM1	Antibody N3-1 bound to RBDs in the up and down conformations 分子名称: N3-1 Fab heavy chain, N3-1 Fab light chain, Spike glycoprotein 著者 Hsieh, C.-L, McLellan, J.S. 登録日 2023-07-27 公開日 2024-01-17 実験手法 ELECTRON MICROSCOPY (2.79 Å) 主引用文献 SARS-COV-2 Omicron variants conformationally escape a rare quaternary antibody binding mode. Commun Biol, 6, 2023
8TM0	Preclinical Characterization of Pan-NKG2D Ligand-Binding NKG2D Receptor Decoys 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class I polypeptide-related sequence A, ... 著者 Rupert, P.B, Strong, R. 登録日 2023-07-27 公開日 2024-04-17 実験手法 X-RAY DIFFRACTION (3.83 Å) 主引用文献 Preclinical characterization of Pan-NKG2D ligand-binding NKG2D receptor decoys. Heliyon, 10, 2024
8TLZ	Preclinical Characterization of Pan-NKG2D Ligand-Binding NKG2D Receptor Decoys 分子名称: (2S)-2-hydroxybutanedioic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... 著者 Rupert, P.B, Strong, R. 登録日 2023-07-27 公開日 2024-04-17 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Preclinical characterization of Pan-NKG2D ligand-binding NKG2D receptor decoys. Heliyon, 10, 2024
8TLX	Crystal structure of MBP and AF9 AHD fusion protein 3AQA in complex with peptidomimetic inhibitor 21a 分子名称: GLYCEROL, MBP and AF9 AHD fusion protein 3AQA, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... 著者 Yang, Y, Nikolovska-Coleska, Z. 登録日 2023-07-27 公開日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.097 Å) 主引用文献 Structural studies of intrinsically disordered MLL-fusion protein AF9 in complex with peptidomimetic inhibitors. Protein Sci., 33, 2024
8TLW	Crystal structure of MBP and AF9 AHD fusion protein 3AQA in complex with peptidomimetic inhibitor 28 分子名称: MBP and AF9 AHD fusion protein 3AQA, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, peptidomimetic inhibitor 28 著者 Yang, Y, Nikolovska-Coleska, Z. 登録日 2023-07-27 公開日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.106 Å) 主引用文献 Structural studies of intrinsically disordered MLL-fusion protein AF9 in complex with peptidomimetic inhibitors. Protein Sci., 33, 2024
8TLV	Crystal structure of MBP and AF9 AHD fusion protein 4AQK in complex with peptidomimetic inhibitor 28 分子名称: GLUTATHIONE, MBP and AF9 AHD fusion protein 4AQK, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... 著者 Yang, Y, Nikolovska-Coleska, Z. 登録日 2023-07-27 公開日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.659 Å) 主引用文献 Structural studies of intrinsically disordered MLL-fusion protein AF9 in complex with peptidomimetic inhibitors. Protein Sci., 33, 2024
8TLU	E. coli MraY mutant-T23P 分子名称: Phospho-N-acetylmuramoyl-pentapeptide-transferase 著者 Orta, A.K, Li, Y.E, Clemons, W.M. 登録日 2023-07-27 公開日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Synthesis of lipid-linked precursors of the bacterial cell wall is governed by a feedback control mechanism in Pseudomonas aeruginosa. Nat Microbiol, 9, 2024
8TLT	Cryo-EM structure of Rev1(deltaN)-Polzeta-DNA-dCTP complex 分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*TP*AP*AP*TP*GP*GP*TP*AP*GP*GP*GP*GP*AP*GP*GP*GP*AP*AP*T)-3'), ... 著者 Malik, R, Aggarwal, A.K. 登録日 2023-07-27 公開日 2024-05-15 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (2.85 Å) 主引用文献 Cryo-EM structure of the Rev1-Pol zeta holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis. Nat.Struct.Mol.Biol., 2024
8TLS	Crystal structure of Shewanella benthica Group 1 truncated hemoglobin C51S C71S Y108A variant 分子名称: CYANIDE ION, Group 1 truncated hemoglobin, PROTOPORPHYRIN IX CONTAINING FE 著者 Schultz, T.D, Martinez, J.E, Siegler, M.A, Schlessman, J.L, Lecomte, J.T.J. 登録日 2023-07-27 公開日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of Shewanella benthica Group 1 truncated hemoglobin C51S C71S Y108A variant To Be Published
8TLQ	Cryo-EM structure of the Rev1-Polzeta-DNA-dCTP complex 分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (30-MER), ... 著者 Malik, R, Aggarwal, A.K. 登録日 2023-07-27 公開日 2024-05-15 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.53 Å) 主引用文献 Cryo-EM structure of the Rev1-Pol zeta holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis. Nat.Struct.Mol.Biol., 2024
8TLN	STRUCTURAL COMPARISON SUGGESTS THAT THERMOLYSIN AND RELATED NEUTRAL PROTEASES UNDERGO HINGE-BENDING MOTION DURING CATALYSIS 分子名称: CALCIUM ION, DIMETHYL SULFOXIDE, LYSINE, ... 著者 Tronrud, D, Matthews, B.W. 登録日 1993-09-01 公開日 1994-04-30 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural comparison suggests that thermolysin and related neutral proteases undergo hinge-bending motion during catalysis. Biochemistry, 31, 1992
8TLM	Structure of a class A GPCR/Fab complex 分子名称: C-C chemokine receptor type 8, Green fluorescent protein fusion, Fab heavy chain, ... 著者 Sun, D, Johnson, M, Masureel, M. 登録日 2023-07-27 公開日 2023-12-20 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8. Nat Commun, 14, 2023
8TLI	THERMOLYSIN (100% ISOPROPANOL SOAKED CRYSTALS) 分子名称: CALCIUM ION, DIMETHYL SULFOXIDE, ISOPROPYL ALCOHOL, ... 著者 English, A.C, Done, S.H, Groom, C.R, Hubbard, R.E. 登録日 1998-10-30 公開日 2000-03-13 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Locating interaction sites on proteins: the crystal structure of thermolysin soaked in 2% to 100% isopropanol. Proteins, 37, 1999
8TLD	Structure of the IL-5 Signaling Complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit beta, Interleukin-5, ... 著者 Caveney, N.A, Garcia, K.C. 登録日 2023-07-26 公開日 2024-04-10 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Organizing structural principles of common beta family signaling To Be Published

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