1YH5
 
 | | Solution NMR Structure of Protein yggU from Escherichia coli. Northeast Structural Genomics Consortium Target ER14. | | 分子名称: | ORF, HYPOTHETICAL PROTEIN | | 著者 | Aramini, J.M, Xiao, R, Huang, Y.J, Acton, T.B, Wu, M.J, Mills, J.L, Tejero, R.T, Szyperski, T, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2005-01-06 | | 公開日 | 2005-02-01 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structure of the Hypothetical Protein Yggu from E. Coli. Northeast Structural Genomics Consortium Target Er14.
To be Published
|
|
5ENK
 | | Compound 18 | | 分子名称: | (4~{S},6~{S})-4-[2,4-bis(fluoranyl)-5-pyrimidin-5-yl-phenyl]-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine, Beta-secretase 1, GLYCEROL, ... | | 著者 | Lewis, H.A. | | 登録日 | 2015-11-09 | | 公開日 | 2016-07-06 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain A beta Reduction in Rodents.
Acs Med.Chem.Lett., 7, 2016
|
|
5C0A
 | | 1E6 TCR in complex with HLA-A02 carrying MVW peptide | | 分子名称: | 1,2-ETHANEDIOL, 1E6 TCR Alpha Chain, 1E6 TCR Beta Chain, ... | | 著者 | Rizkallah, P.J, Bulek, A.M, Cole, D.K, Sewell, A.K. | | 登録日 | 2015-06-12 | | 公開日 | 2016-05-04 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.
J.Clin.Invest., 126, 2016
|
|
5ENY
 | |
5C18
 | |
5UV5
 | | Crystal Structure of a 2-Hydroxyisoquinoline-1,3-dione RNase H Active Site Inhibitor with Multiple Binding Modes to HIV Reverse Transcriptase | | 分子名称: | 7-(furan-2-yl)-2-hydroxyisoquinoline-1,3(2H,4H)-dione, MANGANESE (II) ION, Reverse transcriptase/ribonuclease H, ... | | 著者 | Kirby, K.A, Sarafianos, S.G. | | 登録日 | 2017-02-19 | | 公開日 | 2017-08-16 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | A 2-Hydroxyisoquinoline-1,3-Dione Active-Site RNase H Inhibitor Binds in Multiple Modes to HIV-1 Reverse Transcriptase.
Antimicrob. Agents Chemother., 61, 2017
|
|
5URS
 | | Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Bacillus anthracis in the complex with IMP and the inhibitor P178 | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | | 著者 | Kim, Y, Maltseva, N, Makowska-Grzyska, M, Gu, M, Gollapalli, D, Hedstrom, L, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2017-02-12 | | 公開日 | 2017-03-08 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.388 Å) | | 主引用文献 | Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from
Bacillus anthracis in the complex with IMP and the inhibitor P178
To Be Published
|
|
2BA0
 | | Archaeal exosome core | | 分子名称: | Archaeal exosome RNA binding protein RRP4, Archaeal exosome RNA binding protein RRP41, Archaeal exosome RNA binding protein RRP42 | | 著者 | Buttner, K, Wenig, K, Hopfner, K.P. | | 登録日 | 2005-10-13 | | 公開日 | 2005-11-22 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural framework for the mechanism of archaeal exosomes in RNA processing.
Mol.Cell, 20, 2005
|
|
4A8D
 | | DegP dodecamer with bound OMP | | 分子名称: | OUTER MEMBRANE PROTEIN C, PERIPLASMIC SERINE ENDOPROTEASE DEGP | | 著者 | Malet, H, Krojer, T, Sawa, J, Schafer, E, Saibil, H.R, Ehrmann, M, Clausen, T. | | 登録日 | 2011-11-20 | | 公開日 | 2012-01-11 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (28 Å) | | 主引用文献 | Newly Folded Substrates Inside the Molecular Cage of the Htra Chaperone Degq
Nat.Struct.Mol.Biol., 19, 2012
|
|
4ZSM
 | | BACE crystal structure with bicyclic aminothiazine fragment | | 分子名称: | (4aS,8aR)-4a,5,6,7,8,8a-hexahydro-4H-3,1-benzothiazin-2-amine, Beta-secretase 1, GLYCEROL | | 著者 | Timm, D.E. | | 登録日 | 2015-05-13 | | 公開日 | 2015-06-10 | | 最終更新日 | 2015-06-17 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Preparation and biological evaluation of conformationally constrained BACE1 inhibitors.
Bioorg.Med.Chem., 23, 2015
|
|
4ZSF
 | | Crystal structure of pre-specific restriction endonuclease BsaWI-DNA complex | | 分子名称: | BsaWI endonuclease, CALCIUM ION, DNA, ... | | 著者 | Tamulaitiene, G, Rutkauskas, M, Grazulis, S, Siksnys, V. | | 登録日 | 2015-05-13 | | 公開日 | 2015-10-07 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Functional significance of protein assemblies predicted by the crystal structure of the restriction endonuclease BsaWI.
Nucleic Acids Res., 43, 2015
|
|
4A59
 | |
2B53
 | |
4ZT8
 | | Structure of the complex of type 1 ribosome inactivating protein from Momordica balsamina with a pyrimidine base, cytosine at 1.98 A resolution | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-AMINOPYRIMIDIN-2(1H)-ONE, GLYCEROL, ... | | 著者 | Yamini, S, Pandey, S, Kaur, P, Sharma, S, Singh, T.P. | | 登録日 | 2015-05-14 | | 公開日 | 2015-06-03 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Binding and structural studies of the complexes of type 1 ribosome inactivating protein fromMomordica balsaminawith cytosine, cytidine, and cytidine diphosphate.
Biochem Biophys Rep, 4, 2015
|
|
2B4G
 | | dihydroorotate dehydrogenase | | 分子名称: | BROMIDE ION, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | | 著者 | Arakaki, T.L, Merritt, E.A, Structural Genomics of Pathogenic Protozoa Consortium (SGPP) | | 登録日 | 2005-09-23 | | 公開日 | 2005-10-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies
Mol.Microbiol., 68, 2008
|
|
4A8X
 | | Structure of the core ASAP complex | | 分子名称: | HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18, HOOK-LIKE, ISOFORM A, ... | | 著者 | Murachelli, A.G, Ebert, J, Basquin, C, Le Hir, H, Conti, E. | | 登録日 | 2011-11-21 | | 公開日 | 2012-03-07 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The Structure of the Asap Core Complex Reveals the Existence of a Pinin-Containing Psap Complex
Nat.Struct.Mol.Biol., 19, 2012
|
|
2B54
 | | Human cyclin dependent kinase 2 (CKD2)complexed with DIN-232305 | | 分子名称: | 6-(3,4-DIHYDROXYBENZYL)-3-ETHYL-1-(2,4,6-TRICHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4(5H)-ONE, Cell division protein kinase 2 | | 著者 | Chang, C.-C. | | 登録日 | 2005-09-27 | | 公開日 | 2005-10-11 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1h-pyraxolo[3,4-d]pyrimidin-4-one inhibitors of cyclin dependent kinases
J.Med.Chem., 47, 2004
|
|
4AB7
 | | Crystal structure of a tetrameric acetylglutamate kinase from Saccharomyces cerevisiae complexed with its substrate N- acetylglutamate | | 分子名称: | N-ACETYL-L-GLUTAMATE, PROTEIN ARG5,6, MITOCHONDRIAL | | 著者 | de Cima, S, Gil-Ortiz, F, Crabeel, M, Fita, I, Rubio, V. | | 登録日 | 2011-12-07 | | 公開日 | 2012-05-02 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | Insight on an Arginine Synthesis Metabolon from the Tetrameric Structure of Yeast Acetylglutamate Kinase
Plos One, 7, 2012
|
|
1ZKU
 | |
2B5D
 | | Crystal structure of the novel alpha-amylase AmyC from Thermotoga maritima | | 分子名称: | alpha-Amylase | | 著者 | Dickmanns, A, Ballschmiter, M, Liebl, W, Ficner, R. | | 登録日 | 2005-09-28 | | 公開日 | 2006-03-07 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure of the novel alpha-amylase AmyC from Thermotoga maritima.
Acta Crystallogr.,Sect.D, 62, 2006
|
|
5EKE
 | | Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB (F215A mutant) | | 分子名称: | MAGNESIUM ION, URIDINE-5'-DIPHOSPHATE, Uncharacterized glycosyltransferase sll0501 | | 著者 | Ardiccioni, C, Clarke, O.B, Tomasek, D, Banerjee, S, Rajashankar, K.R, Liu, Q, Shapiro, L, Mancia, F, New York Consortium on Membrane Protein Structure (NYCOMPS) | | 登録日 | 2015-11-03 | | 公開日 | 2016-01-06 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (3.001 Å) | | 主引用文献 | Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis.
Nat Commun, 7, 2016
|
|
4A0V
 | | model refined against the Symmetry-free cryo-EM map of TRiC-AMP-PNP | | 分子名称: | T-COMPLEX PROTEIN 1 SUBUNIT BETA | | 著者 | Cong, Y, Schroder, G.F, Meyer, A.S, Jakana, J, Ma, B, Dougherty, M.T, Schmid, M.F, Reissmann, S, Levitt, M, Ludtke, S.L, Frydman, J, Chiu, W. | | 登録日 | 2011-09-13 | | 公開日 | 2012-02-15 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (10.7 Å) | | 主引用文献 | Symmetry-Free Cryo-Em Structures of the Chaperonin Tric Along its ATPase-Driven Conformational Cycle.
Embo J., 31, 2012
|
|
2B7F
 | | Crystal structure of human T-cell leukemia virus protease, a novel target for anti-cancer design | | 分子名称: | (ACE)APQV(STA)VMHP peptide, HTLV protease, PHOSPHATE ION | | 著者 | Li, M, Laco, G.S, Jaskolski, M, Rozycki, J, Alexandratos, J, Wlodawer, A, Gustchina, A. | | 登録日 | 2005-10-04 | | 公開日 | 2005-12-06 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal structure of human T cell leukemia virus protease, a novel target for anticancer drug design
Proc.Natl.Acad.Sci.Usa, 102, 2005
|
|
4ZVS
 | |
5V3C
 | | Crystal structure of TGT in complex with 4-(aminomethane)cyclohexane-1-carboxylic acid | | 分子名称: | DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, Queuine tRNA-ribosyltransferase, ... | | 著者 | Hassaan, E, Heine, A, Klebe, G. | | 登録日 | 2017-03-07 | | 公開日 | 2018-05-16 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.419 Å) | | 主引用文献 | Fragments as Novel Starting Points for tRNA-Guanine Transglycosylase Inhibitors Found by Alternative Screening Strategies.
Chemmedchem, 15, 2020
|
|
