5UV5

Crystal Structure of a 2-Hydroxyisoquinoline-1,3-dione RNase H Active Site Inhibitor with Multiple Binding Modes to HIV Reverse Transcriptase

Summary for 5UV5

Entry DOI	10.2210/pdb5uv5/pdb
Descriptor	Reverse transcriptase/ribonuclease H, p51 RT, MANGANESE (II) ION, ... (4 entities in total)
Functional Keywords	reverse transcriptase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) More
Total number of polymer chains	4
Total formula weight	229110.14
Authors	Kirby, K.A.,Sarafianos, S.G. (deposition date: 2017-02-19, release date: 2017-08-16, Last modification date: 2023-10-04)
Primary citation	Kirby, K.A.,Myshakina, N.A.,Christen, M.T.,Chen, Y.L.,Schmidt, H.A.,Huber, A.D.,Xi, Z.,Kim, S.,Rao, R.K.,Kramer, S.T.,Yang, Q.,Singh, K.,Parniak, M.A.,Wang, Z.,Ishima, R.,Sarafianos, S.G. A 2-Hydroxyisoquinoline-1,3-Dione Active-Site RNase H Inhibitor Binds in Multiple Modes to HIV-1 Reverse Transcriptase. Antimicrob. Agents Chemother., 61:-, 2017 Cited by PubMed: 28760905 DOI: 10.1128/AAC.01351-17 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation