5UV5
Crystal Structure of a 2-Hydroxyisoquinoline-1,3-dione RNase H Active Site Inhibitor with Multiple Binding Modes to HIV Reverse Transcriptase
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003676 | molecular_function | nucleic acid binding |
A | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
A | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
A | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
B | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
B | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
C | 0003676 | molecular_function | nucleic acid binding |
C | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
C | 0004523 | molecular_function | RNA-DNA hybrid ribonuclease activity |
C | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
D | 0003964 | molecular_function | RNA-directed DNA polymerase activity |
D | 0006278 | biological_process | RNA-templated DNA biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | binding site for residue MN A 601 |
Chain | Residue |
A | ASP443 |
A | GLU478 |
A | ASP498 |
A | MN602 |
A | Y55603 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue MN A 602 |
Chain | Residue |
A | Y55603 |
A | ASP443 |
A | ASP498 |
A | ASP549 |
A | MN601 |
site_id | AC3 |
Number of Residues | 9 |
Details | binding site for residue Y55 A 603 |
Chain | Residue |
A | ASP443 |
A | GLU478 |
A | ASP498 |
A | GLN500 |
A | HIS539 |
A | ASP549 |
A | MN601 |
A | MN602 |
C | PRO140 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue MN C 601 |
Chain | Residue |
C | ASP443 |
C | GLU478 |
C | ASP498 |
C | MN602 |
C | Y55603 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue MN C 602 |
Chain | Residue |
C | ASP443 |
C | ASP549 |
C | MN601 |
C | Y55603 |
site_id | AC6 |
Number of Residues | 7 |
Details | binding site for residue Y55 C 603 |
Chain | Residue |
C | ASP443 |
C | GLU478 |
C | ASP498 |
C | HIS539 |
C | ASP549 |
C | MN601 |
C | MN602 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | BINDING: |
Chain | Residue | Details |
B | ASP110 | |
B | ASP185 | |
B | ASP186 | |
D | ASP110 | |
D | ASP185 | |
D | ASP186 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | SITE: Essential for RT p66/p51 heterodimerization |
Chain | Residue | Details |
B | TRP401 | |
B | TRP414 | |
D | TRP401 | |
D | TRP414 | |
C | ASP443 | |
C | GLU478 | |
C | ASP498 | |
C | ASP549 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | SITE: Essential for RT p66/p51 heterodimerization |
Chain | Residue | Details |
A | TRP401 | |
A | TRP414 | |
C | TRP401 | |
C | TRP414 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | SITE: Cleavage; by viral protease; partial |
Chain | Residue | Details |
A | PHE440 | |
C | PHE440 |