PDB: 46006 件ウェブページステータス検索Chemie searchBIRD

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4AA0	P38ALPHA MAP KINASE BOUND TO CMPD 2 分子名称: MITOGEN-ACTIVATED PROTEIN KINASE 14, N-[4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxidanylidene-quinazolin-3-yl]phenyl]-2-morpholin-4-yl-pyridine-4-carboxamide 著者 Gerhardt, S, Hargreaves, D. 登録日 2011-11-30 公開日 2012-05-16 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The Discovery of N-Cyclopropyl-4-Methyl-3-[6--(4-Methylpiperazin-1-Yl-4-Oxoquinazolin-3(4H)-Yl]Benzamide (Azd6703), a Clinical P38Alpha Map Kinase Inhibitor for the Treatment of Inflammatory Diseases Bioorg.Med.Chem.Lett., 22, 2012
6YJ6	Structure of the TFIIIC subcomplex tauA 分子名称: Transcription factor tau 131 kDa subunit, Transcription factor tau 55 kDa subunit, Transcription factor tau 95 kDa subunit,Transcription factor tau 95 kDa subunit 著者 Vorlaender, M.K, Muller, C.W. 登録日 2020-04-02 公開日 2020-09-16 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structure of the TFIIIC subcomplex tau A provides insights into RNA polymerase III pre-initiation complex formation. Nat Commun, 11, 2020
3LFA	Human p38 MAP Kinase in Complex with Dasatinib 分子名称: Mitogen-activated protein kinase 14, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, octyl beta-D-glucopyranoside 著者 Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. 登録日 2010-01-16 公開日 2011-04-20 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Development of novel thiazole-urea compounds which stabalize the inactive conformation of p38 alpha To be Published
4O0M	Crystal structure of T. Elongatus BP-1 Clock Protein KaiC 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase KaiC, MAGNESIUM ION 著者 Pattanayek, R, Egli, M. 登録日 2013-12-13 公開日 2014-05-14 実験手法 X-RAY DIFFRACTION (2.84 Å) 主引用文献 An arginine tetrad as mediator of input-dependent and input-independent ATPases in the clock protein KaiC Acta Crystallogr.,Sect.D, D70, 2014
2ELB	Crystal Structure of the BAR-PH domain of human APPL1 分子名称: Adapter protein containing PH domain, PTB domain and leucine zipper motif 1 著者 Li, J, Mao, X, Dong, L.Q, Liu, F, Tong, L. 登録日 2007-03-27 公開日 2007-05-29 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal Structures of the BAR-PH and PTB Domains of Human APPL1 Structure, 15, 2007
2EEV	Guanine riboswitch U22C, A52G mutant bound to hypoxanthine 分子名称: ACETATE ION, COBALT HEXAMMINE(III), HYPOXANTHINE, ... 著者 Gilbert, S.D, Love, C.E, Batey, R.T. 登録日 2007-02-19 公開日 2007-11-13 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Mutational analysis of the purine riboswitch aptamer domain Biochemistry, 46, 2007
4NIE	Crystal structure of the orphan nuclear receptor ROR(gamma)t ligand-binding domain in complex with small molecule ligand 分子名称: 3-[BENZYL(DIMETHYL)AMMONIO]PROPANE-1-SULFONATE, N-(4-{[benzyl(propyl)amino]methyl}phenyl)-2-[4-(ethylsulfonyl)phenyl]acetamide, Nuclear receptor ROR-gamma, ... 著者 Ma, Y.L, Yang, L.Q. 登録日 2013-11-06 公開日 2013-12-11 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.01 Å) 主引用文献 Discovery of Tertiary Amine and Indole Derivatives as Potent ROR gamma t Inverse Agonists. Acs Med.Chem.Lett., 5, 2014
1NAV	Thyroid Receptor Alpha in complex with an agonist selective for Thyroid Receptor Beta1 分子名称: SULFATE ION, hormone receptor alpha 1, THRA1, ... 著者 Ye, L, Li, Y.L, Mellstrom, K, Mellin, C, Bladh, L.G, Koehler, K, Garg, N, Garcia Collazo, A.M, Litten, C, Husman, B, Persson, K, Ljunggren, J, Grover, G, Sleph, P.G, George, R, Malm, J. 登録日 2002-11-29 公開日 2003-06-17 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Thyroid receptor ligands. 1. Agonist ligands selective for the thyroid receptor beta1. J.Med.Chem., 46, 2003
3LFD	Human p38 MAP Kinase in Complex with RL113 分子名称: 1-{4-[2-(benzyloxy)ethyl]-1,3-thiazol-2-yl}-3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]urea, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside 著者 Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. 登録日 2010-01-16 公開日 2011-04-20 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Development of novel thiazole-urea compounds which stabalize the inactive conformation of p38 alpha To be Published
4NYW	Crystal Structure of the Bromodomain of human CREBBP in complex with a dihydroquinoxalinone ligand 分子名称: (3R)-N-[3-(3,4-dihydroquinolin-1(2H)-yl)propyl]-3-methyl-2-oxo-1,2,3,4-tetrahydroquinoxaline-5-carboxamide, 1,2-ETHANEDIOL, CREB-binding protein, ... 著者 Filippakopoulos, P, Picaud, S, Felletar, I, Rooney, T.P.C, Fedorov, O, Martin, S, Monteiro, O.P, Conway, S.J, von Delft, F, Brennan, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2013-12-11 公開日 2014-01-29 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.43 Å) 主引用文献 Crystal Structure of the Bromodomain of human CREBBP in complex with a dihydroquinoxalinone ligand TO BE PUBLISHED
2EBA	Crystal structure of the putative glutaryl-CoA dehydrogenase from thermus thermophilus 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Putative glutaryl-CoA dehydrogenase 著者 Kumarevel, T.S, Karthe, P, Kuramitsu, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-02-07 公開日 2007-04-01 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Crystal structure of the putative glutaryl-CoA dehydrogenase from thermus thermophilus To be Published
2EHP	Crystal Structure of a Putative protein (AQ1627) from Aquifex aeolicus 分子名称: aq_1627 protein 著者 Kumarevel, T.S, Karthe, P, Nakano, N, Kuramitsu, S, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-03-07 公開日 2007-09-11 最終更新日 2017-10-11 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Crystal Structure of a Putative protein (AQ1627) from Aquifex aeolicus To be Published
4OLA	Crystal Structure of Human Argonaute2 分子名称: 5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*U)-3', ISOPROPYL ALCOHOL, PHENOL, ... 著者 Schirle, N.T, MacRae, I.J. 登録日 2014-01-23 公開日 2014-02-05 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 The crystal structure of human Argonaute2. Science, 336, 2012
2OZA	Structure of p38alpha complex 分子名称: MAP kinase-activated protein kinase 2, Mitogen-activated protein kinase 14 著者 White, A, Pargellis, C.A, Studts, J.M, Werneburg, B.G, Farmer II, B.T. 登録日 2007-02-25 公開日 2007-04-03 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Molecular basis of MAPK-activated protein kinase 2:p38 assembly Proc.Natl.Acad.Sci.Usa, 104, 2007
4OC7	Retinoic acid receptor alpha in complex with (E)-3-(3'-allyl-6-hydroxy-[1,1'-biphenyl]-3-yl)acrylic acid and a fragment of the coactivator TIF2 分子名称: (2E)-3-[6-hydroxy-3'-(prop-2-en-1-yl)biphenyl-3-yl]prop-2-enoic acid, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha 著者 Leysen, S, Scheepstra, M, Brunsveld, L, Milroy, L.G, Ottmann, C. 登録日 2014-01-08 公開日 2014-10-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A natural-product switch for a dynamic protein interface. Angew.Chem.Int.Ed.Engl., 53, 2014
2D6F	Crystal structure of Glu-tRNA(Gln) amidotransferase in the complex with tRNA(Gln) 分子名称: Glutamyl-tRNA(Gln) amidotransferase subunit D, Glutamyl-tRNA(Gln) amidotransferase subunit E, ZINC ION, ... 著者 Nureki, O. 登録日 2005-11-13 公開日 2006-07-11 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Structural basis of RNA-dependent recruitment of glutamine to the genetic code Science, 312, 2006
7JTW	Crystal structure of RORgt with compound (4R)-6-[(2,5-dichloro-3-{[(2R,4R)-1-(cyclopentanecarbonyl)-2-methylpiperidin-4-yl]oxy}phenyl)amino]-6-oxo-4-phenylhexanoic acid 分子名称: (4R)-6-[(2,5-dichloro-3-{[(2R,4R)-1-(cyclopentanecarbonyl)-2-methylpiperidin-4-yl]oxy}phenyl)amino]-6-oxo-4-phenylhexanoic acid, GLYCEROL, RAR-related orphan receptor C isoform a variant, ... 著者 Min, X, Wang, Z. 登録日 2020-08-18 公開日 2021-02-03 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery of 6-Oxo-4-phenyl-hexanoic acid derivatives as ROR gamma t inverse agonists showing favorable ADME profile. Bioorg.Med.Chem.Lett., 36, 2021
2FLT	The X-ray structure of the cis-3-chloroacrylic acid dehalogenase cis-CaaD inactivated with (R)-Oxirane-2-carboxylate 分子名称: LACTIC ACID, cis-3-chloroacrylic acid dehalogenase 著者 de Jong, R.M. 登録日 2006-01-06 公開日 2006-11-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structures of Native and Inactivated cis-3-Chloroacrylic Acid Dehalogenase: STRUCTURAL BASIS FOR SUBSTRATE SPECIFICITY AND INACTIVATION BY (R)-OXIRANE-2-CARBOXYLATE. J.Biol.Chem., 282, 2007
8QA8	Crystal structure of the C-terminally truncated transcriptional repressor protein KorB from the RK2 plasmid complexed with CTP-gamma-S 分子名称: CHLORIDE ION, CYTIDINE-5'-TRIPHOSPHATE, Transcriptional repressor protein KorB 著者 McLean, T.C, Mundy, J.E.A, Lawson, D.M, Le, T.B.K. 登録日 2023-08-22 公開日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of the C-terminally truncated transcriptional repressor protein KorB from the RK2 plasmid complexed with CTP-gamma-S To Be Published
4NB6	Crystal structure of the ligand binding domain of RORC with T0901317 分子名称: N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE, Nuclear receptor ROR-gamma 著者 Hymowitz, S.G, Boenig-de Leon, G. 登録日 2013-10-22 公開日 2013-11-27 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structure-based design of substituted hexafluoroisopropanol-arylsulfonamides as modulators of RORc. Bioorg.Med.Chem.Lett., 23, 2013
7K82	The X-ray crystal structure of SSR4, an S. pombe chromatin remodelling protein: sulfur SAD 分子名称: CHLORIDE ION, GLYCEROL, SWI/SNF and RSC complexes subunit ssr4 著者 Peat, T.S, Newman, J. 登録日 2020-09-24 公開日 2020-12-16 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The X-ray crystal structure of the N-terminal domain of Ssr4, a Schizosaccharomyces pombe chromatin-remodelling protein. Acta Crystallogr.,Sect.F, 76, 2020
8QAO	Crystal structure of TP901-1 CI-NTD89 repressor N-terminal domain 分子名称: CI 著者 Huang, Z, Hamad, G.M, Lo Leggio, L, Varming, A.K. 登録日 2023-08-23 公開日 2024-02-28 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.29 Å) 主引用文献 CI:Mor interactions in the lysogeny switches of Lactococcus lactis TP901-1 and Staphylococcus aureus phi 13 bacteriophages. Microbiome Res Rep, 3, 2024
2FGP	Crystal structure of a minimal, all RNA hairpin ribozyme with modifications (g8dap, u39c) at ph 8.6 分子名称: 5'-R(*CP*GP*GP*UP*GP*AP*(N6G)P*AP*AP*GP*GP*G)-3', 5'-R(*GP*GP*CP*AP*GP*AP*GP*AP*AP*AP*CP*AP*CP*AP*CP*GP*A)-3', 5'-R(*UP*CP*CP*CP*AP*GP*UP*CP*CP*AP*CP*CP*G)-3', ... 著者 Salter, J.D, Wedekind, J.E. 登録日 2005-12-22 公開日 2006-02-14 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Water in the Active Site of an All-RNA Hairpin Ribozyme and Effects of Gua8 Base Variants on the Geometry of Phosphoryl Transfer. Biochemistry, 45, 2006
2PUU	Crystal structure of p38 complex with 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(6-morpholin-4-ylmethyl-pyridin-3-yl)naphthalen-1-yl]urea 分子名称: 5-TERT-BUTYL-2-(4-METHYLPHENYL)-3-{[({4-[6-(MORPHOLIN-4-YLMETHYL)PYRIDIN-3-YL]-1-NAPHTHYL}AMINO)CARBONYL]AMINO}-1H-PYRAZOL-2-IUM, Mitogen-activated protein kinase 14 著者 Qian, K.C. 登録日 2007-05-09 公開日 2008-05-20 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A new class of p38 MAP kinase inhibitors based on the pyrazole-naphthyl urea scaffold To be Published
6H25	Human nuclear RNA exosome EXO-10-MPP6 complex 分子名称: Exosome complex component CSL4, Exosome complex component MTR3, Exosome complex component RRP4, ... 著者 Gerlach, P, Schuller, J.M, Falk, S, Basquin, J, Conti, E. 登録日 2018-07-13 公開日 2018-08-15 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Distinct and evolutionary conserved structural features of the human nuclear exosome complex. Elife, 7, 2018

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