4IBF
| Ebola virus VP35 bound to small molecule | 分子名称: | (4-{(2R)-2-(4-bromothiophen-2-yl)-3-[(5-chlorothiophen-2-yl)carbonyl]-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl}phenyl)acetic acid, Polymerase cofactor VP35 | 著者 | Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2012-12-08 | 公開日 | 2014-03-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.291 Å) | 主引用文献 | In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014
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4IBK
| Ebola virus VP35 bound to small molecule | 分子名称: | 3-{(2S)-2-(7-chloro-1,3-benzodioxol-5-yl)-3-[(5-chlorothiophen-2-yl)carbonyl]-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl}benzoic acid, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K. | 登録日 | 2012-12-08 | 公開日 | 2014-03-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014
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4IBC
| Ebola virus VP35 bound to small molecule | 分子名称: | DIMETHYL SULFOXIDE, Polymerase cofactor VP35, {4-[(2R)-3-(2-chlorobenzoyl)-2-(2-chlorophenyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]phenyl}acetic acid | 著者 | Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K. | 登録日 | 2012-12-08 | 公開日 | 2014-03-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.745 Å) | 主引用文献 | In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014
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5V5G
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2VON
| Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUAAUUU | 分子名称: | 5'-R(*AP*UP*AP*AP*UP*UP*UP)-3', LUPUS LA PROTEIN | 著者 | Kotik-Kogan, O, Valentine, E.R, Sanfelice, D, Conte, M.R, Curry, S. | 登録日 | 2008-02-19 | 公開日 | 2008-05-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3' Ends by the Human La Protein. Structure, 16, 2008
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2VOP
| Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUUUU | 分子名称: | 5'-R(*AP*UP*UP*UP*UP)-3', LUPUS LA PROTEIN, SULFATE ION | 著者 | Kotik-Kogan, O, Valentine, E.R, Sanfelice, D, Conte, M.R, Curry, S. | 登録日 | 2008-02-19 | 公開日 | 2008-05-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural Analysis Reveals Conformational Plasticity in the Recognition of RNA 3' Ends by the Human La Protein. Structure, 16, 2008
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7OOP
| Pol II-CSB-CSA-DDB1-UVSSA-PAF-SPT6 (Structure 3) | 分子名称: | DNA damage-binding protein 1, DNA excision repair protein ERCC-6, DNA excision repair protein ERCC-8, ... | 著者 | Kokic, G, Cramer, P. | 登録日 | 2021-05-28 | 公開日 | 2021-10-06 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis of human transcription-DNA repair coupling. Nature, 598, 2021
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7OPD
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7OPC
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5MY1
| E. coli expressome | 分子名称: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | 著者 | Kohler, R, Mooney, R.A, Mills, D.J, Kostrewa, D, Landick, R, Cramer, P. | 登録日 | 2017-01-25 | 公開日 | 2017-04-26 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (7.6 Å) | 主引用文献 | Architecture of a transcribing-translating expressome. Science, 356, 2017
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5OQM
| STRUCTURE OF YEAST TRANSCRIPTION PRE-INITIATION COMPLEX WITH TFIIH AND CORE MEDIATOR | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | 著者 | Schilbach, S, Hantsche, M, Tegunov, D, Dienemann, C, Wigge, C, Urlaub, H, Cramer, P. | 登録日 | 2017-08-13 | 公開日 | 2018-05-09 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (5.8 Å) | 主引用文献 | Structures of transcription pre-initiation complex with TFIIH and Mediator. Nature, 551, 2017
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5OQJ
| STRUCTURE OF YEAST TRANSCRIPTION PRE-INITIATION COMPLEX WITH TFIIH | 分子名称: | DNA repair helicase RAD25, DNA repair helicase RAD3, DNA-directed RNA polymerase II subunit RPB1, ... | 著者 | Schilbach, S, Hantsche, M, Tegunov, D, Dienemann, C, Wigge, C, Henning, U, Cramer, P. | 登録日 | 2017-08-11 | 公開日 | 2018-04-25 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | 主引用文献 | Structures of transcription pre-initiation complex with TFIIH and Mediator. Nature, 551, 2017
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6GMH
| Structure of activated transcription complex Pol II-DSIF-PAF-SPT6 | 分子名称: | CDC73, CTR9,RNA polymerase-associated protein CTR9 homolog,RNA polymerase-associated protein CTR9 homolog, DNA-directed RNA polymerase II subunit RPB9, ... | 著者 | Vos, S.M, Farnung, L, Boehing, M, Linden, A, Wigge, C, Urlaub, H, Cramer, P. | 登録日 | 2018-05-26 | 公開日 | 2018-08-22 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure of activated transcription complex Pol II-DSIF-PAF-SPT6. Nature, 560, 2018
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1JR6
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7UND
| Pol II-DSIF-SPT6-PAF1c-TFIIS-nucleosome complex (stalled at +38) | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB7, ... | 著者 | Filipovski, M, Vos, S.M, Farnung, L. | 登録日 | 2022-04-10 | 公開日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis of nucleosome retention during transcription elongation. Science, 376, 2022
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7UNC
| Pol II-DSIF-SPT6-PAF1c-TFIIS complex with rewrapped nucleosome | 分子名称: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit RPB3, DNA-directed RNA polymerase II subunit RPB7, ... | 著者 | Filipovski, M, Vos, S.M, Farnung, L. | 登録日 | 2022-04-10 | 公開日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis of nucleosome retention during transcription elongation. Science, 376, 2022
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5IY6
| Human holo-PIC in the closed state | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | 著者 | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | 登録日 | 2016-03-24 | 公開日 | 2016-05-18 | 最終更新日 | 2019-11-20 | 実験手法 | ELECTRON MICROSCOPY (7.2 Å) | 主引用文献 | Near-atomic resolution visualization of human transcription promoter opening. Nature, 533, 2016
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5IY9
| Human holo-PIC in the initial transcribing state (no IIS) | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | 著者 | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | 登録日 | 2016-03-24 | 公開日 | 2016-05-18 | 最終更新日 | 2019-11-20 | 実験手法 | ELECTRON MICROSCOPY (6.3 Å) | 主引用文献 | Near-atomic resolution visualization of human transcription promoter opening. Nature, 533, 2016
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6IN7
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5KRG
| RNA 15mer duplex binding with PZG monomer | 分子名称: | RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*G)-3'), [(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-(3-methyl-1~{H}-pyrazol-4-yl)phosphinic acid | 著者 | Zhang, W, Tam, C.P, Szostak, J.W. | 登録日 | 2016-07-07 | 公開日 | 2016-12-07 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Unusual Base-Pairing Interactions in Monomer-Template Complexes. ACS Cent Sci, 2, 2016
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5IY8
| Human holo-PIC in the initial transcribing state | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | 著者 | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | 登録日 | 2016-03-24 | 公開日 | 2016-05-18 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (7.9 Å) | 主引用文献 | Near-atomic resolution visualization of human transcription promoter opening. Nature, 533, 2016
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5IY7
| Human holo-PIC in the open state | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB10, DNA-directed RNA polymerase II subunit RPB11-a, ... | 著者 | He, Y, Yan, C, Fang, J, Inouye, C, Tjian, R, Ivanov, I, Nogales, E. | 登録日 | 2016-03-24 | 公開日 | 2016-05-18 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (8.6 Å) | 主引用文献 | Near-atomic resolution visualization of human transcription promoter opening. Nature, 533, 2016
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6TED
| Structure of complete, activated transcription complex Pol II-DSIF-PAF-SPT6 uncovers allosteric elongation activation by RTF1 | 分子名称: | DNA (37-MER), DNA-directed RNA polymerase II subunit RPB9, DNA-directed RNA polymerase subunit, ... | 著者 | Vos, S.M, Farnung, L, Cramer, P. | 登録日 | 2019-11-11 | 公開日 | 2020-07-22 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure of complete Pol II-DSIF-PAF-SPT6 transcription complex reveals RTF1 allosteric activation. Nat.Struct.Mol.Biol., 27, 2020
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1TAQ
| STRUCTURE OF TAQ DNA POLYMERASE | 分子名称: | 2-O-octyl-beta-D-glucopyranose, TAQ DNA POLYMERASE, ZINC ION | 著者 | Kim, Y, Eom, S.H, Wang, J, Lee, D.-S, Suh, S.W, Steitz, T.A. | 登録日 | 1996-06-04 | 公開日 | 1996-12-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of Thermus aquaticus DNA polymerase. Nature, 376, 1995
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7EGC
| p53-bound TFIID-based holo PIC on HDM2 promoter | 分子名称: | CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ... | 著者 | Chen, X, Wu, Z, Hou, H, Qi, Y, Wang, X, Li, J, Xu, Y. | 登録日 | 2021-03-24 | 公開日 | 2021-05-12 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structural insights into preinitiation complex assembly on core promoters. Science, 372, 2021
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