PDB: 22592 件ウェブページステータス検索Chemie searchBIRD

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8IVI	crystal structure of a medium-long chain fatty acyl-CoA ligase 分子名称: Medium/long-chain-fatty-acid--CoA ligase FadD8 著者 Li, S. 登録日 2023-03-27 公開日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Structural study of medium-long chain fatty acyl-CoA ligase FadD8 from Mycobacterium tuberculosis. Biochem.Biophys.Res.Commun., 672, 2023
8ZJB	Oomycete Nudix effectors display WY-Nudix conformations with mRNA decapping activity 分子名称: Nudix hydrolase domain-containing protein 著者 Xing, W, Xing, W. 登録日 2024-05-14 公開日 2024-07-03 最終更新日 2024-08-28 実験手法 X-RAY DIFFRACTION (3.19 Å) 主引用文献 Oomycete Nudix effectors display WY-Nudix conformation and mRNA decapping activity. J Integr Plant Biol, 66, 2024
5XE3	Endoribonuclease in complex with its cognate antitoxin from Mycobacterial species 分子名称: Endoribonuclease MazF4, Probable antitoxin MazE4 著者 Ahn, D.-H, Lee, K.-Y, Lee, S.J, Yoon, H.J, Kim, S.-J, Lee, B.-J. 登録日 2017-03-31 公開日 2017-10-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural analyses of the MazEF4 toxin-antitoxin pair in Mycobacterium tuberculosis provide evidence for a unique extracellular death factor. J. Biol. Chem., 292, 2017
6EIC	Crystal structure of Rv0183, a Monoglyceride Lipase from Mycobacterium Tuberculosis 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Mycobacterium Tuberculosis Monoglyceride Lipase, NITRATE ION, ... 著者 Aschauer, P, Pavkov-Keller, T, Oberer, M. 登録日 2017-09-19 公開日 2018-06-27 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The crystal structure of monoacylglycerol lipase from M. tuberculosis reveals the basis for specific inhibition. Sci Rep, 8, 2018
5KS2	RAWV_CTD (Helix form) of 16S/23S 2'-O-methyltransferase TlyA 分子名称: 16S/23S rRNA (cytidine-2'-O)-methyltransferase TlyA, CHLORIDE ION 著者 Kuiper, E.G, Conn, G.L. 登録日 2016-07-07 公開日 2017-01-04 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 A Novel Motif for S-Adenosyl-l-methionine Binding by the Ribosomal RNA Methyltransferase TlyA from Mycobacterium tuberculosis. J. Biol. Chem., 292, 2017
5KYG	RAWV_CTD (Loop Structure) of 16S/23S 2'-O-methyltransferase TlyA 分子名称: Cytotoxin / haemolysin homologue TlyA, GLYCEROL 著者 Kuiper, E.G, Conn, G.L. 登録日 2016-07-21 公開日 2017-01-04 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A Novel Motif for S-Adenosyl-l-methionine Binding by the Ribosomal RNA Methyltransferase TlyA from Mycobacterium tuberculosis. J. Biol. Chem., 292, 2017
6CUU	Thermus thermophiles RNA polymerase in complex with promoter DNA and antibiotic Kanglemycin A 分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*CP*TP*CP*TP*GP*AP*TP*GP*CP*A)-3'), DNA (5'-D(P*TP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*AP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Molodtsov, V, Murakami, K.S. 登録日 2018-03-26 公開日 2018-07-25 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.994 Å) 主引用文献 Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis. Mol. Cell, 72, 2018
1NYO	Solution structure of the antigenic TB protein MPT70/MPB70 分子名称: Immunogenic protein MPT70 著者 Bloemink, M.J, Dentten, E, Hewinson, R.G, Williamson, R.A, Carr, M.D, TB Structural Genomics Consortium (TBSGC) 登録日 2003-02-13 公開日 2003-08-19 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 Solution structure of the Mycobacterium tuberculosis complex protein MPB70: from tuberculosis pathogenesis to inherited human corneal desease J.Biol.Chem., 278, 2003
8J5U	Crystal structure of Mycobacterium tuberculosis OppA complexed with an endogenous oligopeptide 分子名称: Endogenous oligopeptide, Uncharacterized protein Rv1280c 著者 Yang, X, Hu, T, Zhang, B, Rao, Z. 登録日 2023-04-24 公開日 2024-04-03 最終更新日 2024-07-31 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 An oligopeptide permease, OppABCD, requires an iron-sulfur cluster domain for functionality. Nat.Struct.Mol.Biol., 31, 2024
3VEH	Structure of a M. tuberculosis salicylate synthase, MbtI, in complex with an inhibitor methylAMT 分子名称: 3-{[(1Z)-1-carboxyprop-1-en-1-yl]oxy}-2-hydroxybenzoic acid, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... 著者 Bulloch, E.M, Chi, G, Manos-Turvey, A, Johnston, J.M, Baker, E.N, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC) 登録日 2012-01-08 公開日 2012-06-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis. Biochemistry, 51, 2012
7P13	2.29 A Mycobacterium tuberculosis EspB. 分子名称: ESX-1 secretion-associated protein EspB 著者 Gijsbers, A, Zhang, Y, Vinciauskaite, V, Siroy, A, Gao, Y, Tria, G, Mathew, A, Sanchez-Puig, N, Lopez-Iglesias, C, Peters, P.J, Ravelli, R.B.G. 登録日 2021-07-01 公開日 2021-08-18 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (2.29 Å) 主引用文献 Priming mycobacterial ESX-secreted protein B to form a channel-like structure. Curr Res Struct Biol, 3, 2021
7QQ7	Crystal structure of CYP142 from Mycobacterium tuberculosis in complex with an inhibitor at partial occupancy with PEG 分子名称: ACETATE ION, BROMIDE ION, CHLORIDE ION, ... 著者 Snee, M, Levy, C, Kavanagh, M. 登録日 2022-01-06 公開日 2023-01-18 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Crystal structure of CYP142 from Mycobacterium tuberculosis in complex with an inhibitor at partial occupancy with PEG To Be Published
6CUX	Escherichia coli RpoB S531L mutant RNA polymerase holoenzyme in complex with Kanglemycin A 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Molodtsov, V, Murakami, K.S. 登録日 2018-03-26 公開日 2018-07-25 最終更新日 2020-01-01 実験手法 X-RAY DIFFRACTION (4.104 Å) 主引用文献 Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis. Mol. Cell, 72, 2018
6CVC	Mycobacterium marinum cytochrome P450 CYP124A1 in the substrate-free form 分子名称: Cytochrome P450 124A1, Cyp124A1, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Child, S.A, Bruning, J.B, Bell, S.G. 登録日 2018-03-27 公開日 2019-03-27 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 A comparison of the steroid binding cytochrome P450s from Mycobacterium marinum and Mycobacterium tuberculosis To Be Published
7RYT	Crystal structure of Mycobacterium tuberculosis acetylated Homoserine transacetylase with Coenzyme A 分子名称: COENZYME A, DI(HYDROXYETHYL)ETHER, Homoserine O-acetyltransferase, ... 著者 Jayasinghe, Y.P, Ronning, D.R. 登録日 2021-08-26 公開日 2023-02-22 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.67 Å) 主引用文献 Structural and Functional Characterization of Mycobacterium tuberculosis Homoserine Transacetylase. Acs Infect Dis., 9, 2023
5I7N	MaoC-like dehydratase 分子名称: MaoC-like dehydratase 著者 Blaise, M. 登録日 2016-02-18 公開日 2016-07-06 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Deletion of a dehydratase important for intracellular growth and cording renders rough Mycobacterium abscessus avirulent. Proc.Natl.Acad.Sci.USA, 113, 2016
4P8T	Crystal structure of M. tuberculosis DprE1 in complex with the non-covalent inhibitor QN129 分子名称: (2R)-2-{[(2R)-2-{[(2R)-2-hydroxypropyl]oxy}propyl]oxy}propan-1-ol, 3-[(4-cyanobenzyl)amino]-6-(trifluoromethyl)quinoxaline-2-carboxylic acid, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Neres, J, Pojer, F, Cole, S.T. 登録日 2014-04-01 公開日 2014-12-10 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1. Acs Chem.Biol., 10, 2015
4P8N	Crystal structure of M. tuberculosis DprE1 in complex with the non-covalent inhibitor QN118 分子名称: 3-[(3-fluoro-4-methoxybenzyl)amino]-6-(trifluoromethyl)quinoxaline-2-carboxylic acid, FLAVIN-ADENINE DINUCLEOTIDE, IMIDAZOLE, ... 著者 Neres, J, Pojer, F, Cole, S.T. 登録日 2014-03-31 公開日 2014-12-10 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1. Acs Chem.Biol., 10, 2015
4P8K	Crystal structure of M. tuberculosis DprE1 in complex with the non-covalent inhibitor Ty38c 分子名称: 3-[(4-methoxybenzyl)amino]-6-(trifluoromethyl)quinoxaline-2-carboxylic acid, FLAVIN-ADENINE DINUCLEOTIDE, Probable decaprenylphosphoryl-beta-D-ribose oxidase 著者 Neres, J, Pojer, F, Cole, S.T. 登録日 2014-03-31 公開日 2014-12-10 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.49 Å) 主引用文献 2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1. Acs Chem.Biol., 10, 2015
4P8L	Crystal structure of M. tuberculosis DprE1 in complex with the non-covalent inhibitor Ty36c 分子名称: 3-[(4-fluorobenzyl)amino]-6-(trifluoromethyl)quinoxaline-2-carboxylic acid, FLAVIN-ADENINE DINUCLEOTIDE, IMIDAZOLE, ... 著者 Neres, J, Pojer, F, Cole, S.T. 登録日 2014-03-31 公開日 2014-12-10 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1. Acs Chem.Biol., 10, 2015
7ZIC	Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor 分子名称: CHLORIDE ION, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Snee, M, Levy, C, Kavanagh, M. 登録日 2022-04-07 公開日 2023-04-19 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor To Be Published
7ZGL	Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor 分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Snee, M, Levy, C, Kavanagh, M. 登録日 2022-04-04 公開日 2023-04-19 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor To Be Published
1NLR	ENDO-1,4-BETA-GLUCANASE CELB2, CELLULASE, NATIVE STRUCTURE 分子名称: ENDO-1,4-BETA-GLUCANASE 著者 Sulzenbacher, G, Dupont, C, Davies, G.J. 登録日 1997-10-27 公開日 1998-11-25 最終更新日 2022-12-21 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 The Streptomyces lividans family 12 endoglucanase: construction of the catalytic cre, expression, and X-ray structure at 1.75 A resolution. Biochemistry, 36, 1997
4P8C	Crystal structure of M. tuberculosis DprE1 in complex with the non-covalent inhibitor QN127 分子名称: (2R)-2-{[(2R)-2-{[(2R)-2-hydroxypropyl]oxy}propyl]oxy}propan-1-ol, 6-(trifluoromethyl)-3-{[4-(trifluoromethyl)benzyl]amino}quinoxaline-2-carboxylic acid, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Neres, J, Pojer, F, Cole, S.T. 登録日 2014-03-31 公開日 2014-12-10 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1. Acs Chem.Biol., 10, 2015
4P8M	Crystal structure of M. tuberculosis DprE1 in complex with the non-covalent inhibitor QN114 分子名称: (2R)-2-{[(2R)-2-{[(2R)-2-hydroxypropyl]oxy}propyl]oxy}propan-1-ol, 3-[(4-ethoxybenzyl)amino]-6-(trifluoromethyl)quinoxaline-2-carboxylic acid, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Neres, J, Pojer, F, Cole, S.T. 登録日 2014-03-31 公開日 2014-12-10 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.09 Å) 主引用文献 2-Carboxyquinoxalines Kill Mycobacterium tuberculosis through Noncovalent Inhibition of DprE1. Acs Chem.Biol., 10, 2015

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