PDB: 243083 件ウェブページステータス検索Chemie searchBIRD

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7TN7	Crystal structure of Zea mays Inositol-tetrakisphosphate Kinase 1 mutant (ZmITPK1 residues 18-218-Gly-Ser-Gly-Ser-Gly-248-328) 分子名称: CHLORIDE ION, Inositol-tetrakisphosphate 1-kinase 1, PHOSPHATE ION 著者 Zong, G, Wang, H, Shears, S.B. 登録日 2022-01-20 公開日 2022-06-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural and catalytic analyses of the InsP 6 kinase activities of higher plant ITPKs. Faseb J., 36, 2022
5J4D	E. coli release factor 1 bound to the 70S ribosome in response to a pseudouridylated stop codon 分子名称: 16S ribosomal RNA, 25S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Svidritskiy, E, Korostelev, A.A. 登録日 2016-03-31 公開日 2016-05-18 最終更新日 2025-03-19 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural Basis for Translation Termination on a Pseudouridylated Stop Codon. J.Mol.Biol., 428, 2016
5SX4	Crystal Structure of panitumumab in complex with epidermal growth factor receptor domain 3. 分子名称: 1,2-ETHANEDIOL, Epidermal growth factor receptor, GLYCEROL, ... 著者 Sickmier, E.A, Kurzeja, R.J.M, Michelsen, K, Mukta, V, Yang, E, Tasker, A.S. 登録日 2016-08-09 公開日 2016-10-05 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The Panitumumab EGFR Complex Reveals a Binding Mechanism That Overcomes Cetuximab Induced Resistance. Plos One, 11, 2016
4EDM	Crystal structure of beta-parvin CH2 domain 分子名称: 1,2-ETHANEDIOL, Beta-parvin 著者 Stiegler, A.L, Draheim, K.M, Li, X, Chayen, N.E, Calderwood, D.A, Boggon, T.J. 登録日 2012-03-27 公開日 2012-08-08 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural basis for paxillin binding and focal adhesion targeting of beta-parvin. J.Biol.Chem., 287, 2012
1JRI	The Crystal Structure of an Sm-like Archaeal Protein with Two Heptamers in the Asymmetric Unit. 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Sm-like Archaeal Protein 1 (SmAP1) 著者 Mura, C, Eisenberg, D. 登録日 2001-08-13 公開日 2002-02-13 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The oligomerization and ligand-binding properties of Sm-like archaeal proteins (SmAPs) Protein Sci., 12, 2003
3L8H	Crystal Structure of D,D-heptose 1.7-bisphosphate phosphatase from B. bronchiseptica complexed with magnesium and phosphate 分子名称: FORMIC ACID, MAGNESIUM ION, PHOSPHATE ION, ... 著者 Nguyen, H, Peisach, E, Allen, K.N. 登録日 2009-12-31 公開日 2010-02-02 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 Structural Determinants of Substrate Recognition in the HAD Superfamily Member d-glycero-d-manno-Heptose-1,7-bisphosphate Phosphatase (GmhB) . Biochemistry, 49, 2010
4Y5A	Endothiapepsin in complex with fragment 206 分子名称: 1,2-ETHANEDIOL, 1-[5-(trifluoromethyl)furan-2-yl]methanamine, ACETATE ION, ... 著者 Ehrmann, F.R, Huschmann, F.U, Heine, A, Klebe, G. 登録日 2015-02-11 公開日 2016-03-02 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Crystallographic Fragment Sreening of an Entire Library To Be Published
4NL1	Crystal structure of B. anthracis DHPS with compound 11: (E)-N-[4-(trifluoromethyl)benzyl]-1-[4-(trifluoromethyl)phenyl]methanimine 分子名称: (E)-N-[4-(trifluoromethyl)benzyl]-1-[4-(trifluoromethyl)phenyl]methanimine, Dihydropteroate Synthase, SULFATE ION 著者 Hammoudeh, D.I, White, S.W. 登録日 2013-11-13 公開日 2014-05-14 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Identification and characterization of an allosteric inhibitory site on dihydropteroate synthase. Acs Chem.Biol., 9, 2014
9G9X	Structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) 分子名称: CHOLESTEROL HEMISUCCINATE, POTASSIUM ION, Potassium channel subfamily K member 3 著者 Rodstrom, K.E.J, Hall, P.H, Tucker, S.J. 登録日 2024-07-25 公開日 2024-12-18 最終更新日 2025-01-15 実験手法 ELECTRON MICROSCOPY (3.13 Å) 主引用文献 Structures of TASK-1 and TASK-3 K2P channels provide insight into their gating and dysfunction in disease. Structure, 33, 2025
7UCK	80S translation initiation complex with ac4c(-1) mRNA and Harringtonine 分子名称: 18S rRNA, 28s rRNA, 40S ribosomal protein S10, ... 著者 Yang, R, Arango, D, Sturgill, D, Oberdoerffer, S. 登録日 2022-03-16 公開日 2022-06-01 最終更新日 2024-12-25 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Direct epitranscriptomic regulation of mammalian translation initiation through N4-acetylcytidine. Mol.Cell, 82, 2022
5TAQ	Structure of rabbit RyR1 (Caffeine/ATP/Ca2+ dataset, class 3&4) 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CAFFEINE, CALCIUM ION, ... 著者 Clarke, O.B, des Georges, A, Zalk, R, Marks, A.R, Hendrickson, W.A, Frank, J. 登録日 2016-09-10 公開日 2016-10-12 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structural Basis for Gating and Activation of RyR1. Cell, 167, 2016
5T36	Crystal structure of mPGES-1 bound to inhibitor 分子名称: 4-chloro-2-[({(1S,2S)-2-[(2,2-dimethylpropanoyl)amino]cyclopentyl}methyl)amino]benzoic acid, GLUTATHIONE, Prostaglandin E synthase, ... 著者 Luz, J.G, Antonysamy, S, Partridge, K, Fisher, M. 登録日 2016-08-24 公開日 2017-03-01 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1. Bioorg. Med. Chem. Lett., 27, 2017
8I5G	Structure of human Nav1.7 in complex with PF-05089771 分子名称: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... 著者 Wu, Q.R, Yan, N. 登録日 2023-01-25 公開日 2023-06-14 最終更新日 2024-10-23 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Structural mapping of Na v 1.7 antagonists. Nat Commun, 14, 2023
4AG7	C. elegans glucosamine-6-phosphate N-acetyltransferase (GNA1): coenzyme A adduct 分子名称: COENZYME A, GLUCOSAMINE-6-PHOSPHATE N-ACETYLTRANSFERASE 著者 Dorfmueller, H.C, Fang, W, Rao, F.V, Blair, D.E, Attrill, H, Shepherd, S.M, van Aalten, D.M.F. 登録日 2012-01-24 公開日 2012-07-25 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Structural and Biochemical Characterization of a Trapped Coenzyme a Adduct of Caenorhabditis Elegans Glucosamine-6-Phosphate N-Acetyltransferase 1. Acta Crystallogr.,Sect.D, 68, 2012
6D20	Crystal structure of Tyrosine-protein kinase receptor in complex with 5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4(3H)-one and 5-{[2,4-dichloro-5-(pyridin-2-yl)benzene-1-carbonyl]amino}-N-(2-hydroxy-2-methylpropyl)-1-phenyl-1H-pyrazole-3-carboxamide Inhibitors 分子名称: 5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4(3H)-one, 5-{[2,4-dichloro-5-(pyridin-2-yl)benzene-1-carbonyl]amino}-N-(2-hydroxy-2-methylpropyl)-1-phenyl-1H-pyrazole-3-carboxamide, High affinity nerve growth factor receptor 著者 Greasley, S.E, Johnson, E, Kraus, M.L, Cronin, C.N. 登録日 2018-04-12 公開日 2018-05-02 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors. J. Med. Chem., 62, 2019
3CTK	Crystal structure of the type 1 RIP bouganin 分子名称: rRNA N-glycosidase 著者 Fermani, S, Tosi, G, Falini, G, Ripamonti, A, Farini, V, Bolognesi, A, Polito, L. 登録日 2008-04-14 公開日 2008-05-27 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure/function studies on two type 1 ribosome inactivating proteins: Bouganin and lychnin. J.Struct.Biol., 168, 2009
4NHC	Crystal structure of the HIV-1 neutralizing antibody 4E10 Fab fragment in complex with a hydrocarbon-stapled peptide containing the 4e10 epitope on gp41. 分子名称: FAB HEAVY CHAIN, FAB LIGHT CHAIN, MODIFIED FRAGMENT OF HIV GLYCOPROTEIN (GP41), ... 著者 Irimia, A, Wilson, I.A. 登録日 2013-11-04 公開日 2014-12-03 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.912 Å) 主引用文献 Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies. Nat.Struct.Mol.Biol., 21, 2014
5E2P	FACTOR XIA IN COMPLEX WITH THE INHIBITOR N-[(1S)-1-benzyl-2-[2-[5-chloro-2-(tetrazol-1-yl)phenyl]ethylamino]-2-oxo-ethyl]-4-hydroxy-2-oxo-1H-quinoline-6-carboxamide 分子名称: 1,2-ETHANEDIOL, Coagulation factor XIa light chain, N-[(1S)-1-benzyl-2-[2-[5-chloro-2-(tetrazol-1-yl)phenyl]ethylamino]-2-oxo-ethyl]-4-hydroxy-2-oxo-1H-quinoline-6-carboxamide, ... 著者 Wei, A. 登録日 2015-10-01 公開日 2015-12-09 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Novel phenylalanine derived diamides as Factor XIa inhibitors. Bioorg.Med.Chem.Lett., 26, 2016
4Y50	Endothiapepsin in complex with fragment 81 分子名称: 1,2-ETHANEDIOL, 3-(dimethylamino)benzohydrazide, ACETATE ION, ... 著者 Schiebel, J, Heine, A, Klebe, G. 登録日 2015-02-11 公開日 2016-03-02 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.32 Å) 主引用文献 Crystallographic Fragment Screening of an Entire Library To Be Published
2VGP	Crystal structure of Aurora B kinase in complex with a aminothiazole inhibitor 分子名称: 4-[(5-bromo-1,3-thiazol-2-yl)amino]-N-methylbenzamide, INNER CENTROMERE PROTEIN A, SERINE/THREONINE-PROTEIN KINASE 12-A 著者 Andersen, C.B, Wan, Y, Chang, J.W, Lee, C, Liu, Y, Sessa, F, Villa, F, Nallan, L, Musacchio, A, Gray, N.S. 登録日 2007-11-15 公開日 2008-02-26 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Discovery of Selective Aminothiazole Aurora Kinase Inhibitors Acs Chem.Biol., 3, 2008
4NKE	The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates 分子名称: 1,2-ETHANEDIOL, 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ... 著者 Tsoumpra, M.K, Barnett, B.L, Muniz, J.R.C, Walter, R.L, Ebetino, F.H, von Delft, F, Russell, R.G.G, Oppermann, U, Dunford, J.E. 登録日 2013-11-12 公開日 2014-11-19 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.46 Å) 主引用文献 The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates To be Published
7BEJ	Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-158 Fab (crystal form 1) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, COVOX-158 heavy chain, COVOX-158 light chain, ... 著者 Zhou, D, Zhao, Y, Ren, J, Stuart, D. 登録日 2020-12-23 公開日 2021-03-03 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 The antigenic anatomy of SARS-CoV-2 receptor binding domain. Cell, 184, 2021
6BMV	Non-receptor Protein Tyrosine Phosphatase SHP2 in Complex with Allosteric Inhibitor SHP504 分子名称: 3-{4-[(2-chlorophenyl)methyl]-5-oxo-4,5-dihydro[1,2,4]triazolo[4,3-a]quinazolin-1-yl}-4-hydroxybenzoic acid, PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 11 著者 Stams, T, Fodor, M. 登録日 2017-11-15 公開日 2018-01-17 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.053 Å) 主引用文献 Dual Allosteric Inhibition of SHP2 Phosphatase. ACS Chem. Biol., 13, 2018
6SMB	Human jak1 kinase domain in complex with inhibitor 分子名称: Tyrosine-protein kinase JAK1, ~{N}-[3-[2-[(3-methoxy-1-methyl-pyrazol-4-yl)amino]-5-methyl-pyrimidin-4-yl]-1~{H}-indol-7-yl]-2-methyl-pyridine-3-carboxamide 著者 Read, J.A, Steuber, H. 登録日 2019-08-21 公開日 2020-04-29 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Discovery of (2R)-N-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor. J.Med.Chem., 63, 2020
3GX9	Structure of morphinone reductase N189A mutant in complex with tetrahydroNAD 分子名称: 1,4,5,6-TETRAHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, FLAVIN MONONUCLEOTIDE, Morphinone reductase 著者 Lafite, P, Scrutton, N.S, Leys, D. 登録日 2009-04-02 公開日 2009-05-26 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.28 Å) 主引用文献 Parallel Pathways and Free-Energy Landscapes for Enzymatic Hydride Transfer Probed by Hydrostatic Pressure Chembiochem, 10, 2009

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