5SX4

Crystal Structure of panitumumab in complex with epidermal growth factor receptor domain 3.

Summary for 5SX4

• Entry DOI: 10.2210/pdb5sx4/pdb
• Related: 5SX5
• Descriptor: Panitumumab Fab Light Chain, Panitumumab Fab Heavy Chain, Epidermal growth factor receptor, ... (8 entities in total)
• Functional Keywords: cetuximab, panitumumab, egfr, vectibix, erbitux, transferase-immune system complex, transferase/immune system
• Biological source: Homo sapiens; More
• Cellular location: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• Total number of polymer chains: 6
• Total formula weight: 140068.46

Authors

Sickmier, E.A.,Kurzeja, R.J.M.,Michelsen, K.,Mukta, V.,Yang, E.,Tasker, A.S. (deposition date: 2016-08-09, release date: 2016-10-05, Last modification date: 2023-10-04)

• Primary citation: Sickmier, E.A.,Kurzeja, R.J.,Michelsen, K.,Vazir, M.,Yang, E.,Tasker, A.S.; The Panitumumab EGFR Complex Reveals a Binding Mechanism That Overcomes Cetuximab Induced Resistance.; Plos One, 11:e0163366-e0163366, 2016; PubMed: 27658254; DOI: 10.1371/journal.pone.0163366

Experimental method

X-RAY DIFFRACTION (2.8 Å)