5SX4
Crystal Structure of panitumumab in complex with epidermal growth factor receptor domain 3.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | I, L | Panitumumab Fab Light Chain | polymer | 214 | 23379.9 | 2 | Homo sapiens | ||
2 | J, H | Panitumumab Fab Heavy Chain | polymer | 221 | 23674.4 | 2 | Homo sapiens | ||
3 | M, N | Epidermal growth factor receptor | polymer | 201 | 22280.3 | 2 | UniProt (P00533) Pfam (PF01030) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
4 | I, L, N | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
5 | I | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
6 | J, H | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 2 | Chemie (1PE) | |||
7 | H | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
8 | water | water | 18.0 | 117 | Chemie (HOH) |
Sequence modifications
M, N: 311 - 501 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Leu 307 | - | expression tag |
Glu 308 | - | expression tag |
Glu 309 | - | expression tag |
Lys 310 | - | expression tag |
Asp 328 | Asn 352 | conflict |
Asp 420 | Asn 444 | conflict |
His 502 | - | expression tag |
His 503 | - | expression tag |
His 504 | - | expression tag |
His 505 | - | expression tag |
His 506 | - | expression tag |
His 507 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 138669.2 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 1399.2 | |
All* | Total formula weight | 140068.5 |