5SX4

Crystal Structure of panitumumab in complex with epidermal growth factor receptor domain 3.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (I, L)	Panitumumab Fab Light Chain	polymer	214	23379.9	2		Homo sapiens
2	B, D (J, H)	Panitumumab Fab Heavy Chain	polymer	221	23674.4	2		Homo sapiens
3	E, F (M, N)	Epidermal growth factor receptor	polymer	201	22280.3	2	UniProt (P00533) Pfam (PF01030)	Homo sapiens (Human)	Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1
4	G, H, I, L, M... (I, L, N)	SULFATE ION	non-polymer		96.1	8	Chemie (SO4)
5	J (I)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
6	K, P (J, H)	PENTAETHYLENE GLYCOL	non-polymer		238.3	2	Chemie (1PE)
7	Q (H)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
8	S, T, U, V, W... (I, J, L, H, M...)	water	water		18.0	117	Chemie (HOH)

Sequence modifications

M, N: 311 - 501 (UniProt: P00533)

PDB	External Database	Details
Leu 307	-	expression tag
Glu 308	-	expression tag
Glu 309	-	expression tag
Lys 310	-	expression tag
Asp 328	Asn 352	conflict
Asp 420	Asn 444	conflict
His 502	-	expression tag
His 503	-	expression tag
His 504	-	expression tag
His 505	-	expression tag
His 506	-	expression tag
His 507	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	138669.2
Non-Polymers*	Number of molecules	12
	Total formula weight	1399.2
All*	Total formula weight	140068.5

*Water molecules are not included.