5SX4

Crystal Structure of panitumumab in complex with epidermal growth factor receptor domain 3.

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue SO4 I 301

Chain	Residue
I	LYS39
I	LYS42
I	LYS45

---

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 I 302

Chain	Residue
I	ASP1
I	GLN27
I	HIS93
M	ASN473

---

site_id	AC3
Number of Residues	1
Details	binding site for residue SO4 I 303

Chain	Residue
I	SER60

---

site_id	AC4
Number of Residues	3
Details	binding site for residue GOL I 304

Chain	Residue
I	PRO8
I	SER9
I	SER7

---

site_id	AC5
Number of Residues	9
Details	binding site for residue 1PE J 301

Chain	Residue
I	GLN38
I	GLY41
I	LYS42
J	ILE94
J	TYR96
J	GLY112
J	MET114
J	GLU154
J	PRO155

---

site_id	AC6
Number of Residues	3
Details	binding site for residue SO4 L 301

Chain	Residue
L	PRO8
L	SER9
L	SER10

---

site_id	AC7
Number of Residues	5
Details	binding site for residue SO4 L 302

Chain	Residue
L	ASP1
L	GLN27
L	HIS93
N	ASN473
N	HOH703

---

site_id	AC8
Number of Residues	3
Details	binding site for residue SO4 L 303

Chain	Residue
L	LYS39
L	LYS42
L	LYS45

---

site_id	AC9
Number of Residues	1
Details	binding site for residue SO4 L 304

Chain	Residue
L	ARG211

---

site_id	AD1
Number of Residues	8
Details	binding site for residue 1PE H 301

Chain	Residue
H	ILE94
H	TYR96
H	GLN111
H	GLY112
H	MET114
H	GLU154
H	PRO155
L	GLY41

---

site_id	AD2
Number of Residues	4
Details	binding site for residue EDO H 302

Chain	Residue
H	GLY32
H	ASP33
N	GLN408
N	ALA415

---

site_id	AD3
Number of Residues	2
Details	binding site for residue SO4 N 601

Chain	Residue
M	HIS359
N	SER474

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCNVDH

Chain	Residue	Details
J	TYR200-HIS206
I	TYR192-HIS198

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10731668","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12297049","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12297050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12620237","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12731890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16083266","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20837704","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MOX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NJP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P0Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UV7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"10731668","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12297050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12620237","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12731890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16083266","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20837704","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NJP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UV7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12731890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16083266","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8962717","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P0Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRP","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12297050","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12620237","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12731890","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16083266","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20837704","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8962717","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1IVO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NQL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B2V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NJP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P0Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3QWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KRP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UIP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4UV7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---