5SX4
Crystal Structure of panitumumab in complex with epidermal growth factor receptor domain 3.
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 I 301 |
| Chain | Residue |
| I | LYS39 |
| I | LYS42 |
| I | LYS45 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 I 302 |
| Chain | Residue |
| I | ASP1 |
| I | GLN27 |
| I | HIS93 |
| M | ASN473 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue SO4 I 303 |
| Chain | Residue |
| I | SER60 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue GOL I 304 |
| Chain | Residue |
| I | PRO8 |
| I | SER9 |
| I | SER7 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | binding site for residue 1PE J 301 |
| Chain | Residue |
| I | GLN38 |
| I | GLY41 |
| I | LYS42 |
| J | ILE94 |
| J | TYR96 |
| J | GLY112 |
| J | MET114 |
| J | GLU154 |
| J | PRO155 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 L 301 |
| Chain | Residue |
| L | PRO8 |
| L | SER9 |
| L | SER10 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 L 302 |
| Chain | Residue |
| L | ASP1 |
| L | GLN27 |
| L | HIS93 |
| N | ASN473 |
| N | HOH703 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 L 303 |
| Chain | Residue |
| L | LYS39 |
| L | LYS42 |
| L | LYS45 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue SO4 L 304 |
| Chain | Residue |
| L | ARG211 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue 1PE H 301 |
| Chain | Residue |
| H | ILE94 |
| H | TYR96 |
| H | GLN111 |
| H | GLY112 |
| H | MET114 |
| H | GLU154 |
| H | PRO155 |
| L | GLY41 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO H 302 |
| Chain | Residue |
| H | GLY32 |
| H | ASP33 |
| N | GLN408 |
| N | ALA415 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 N 601 |
| Chain | Residue |
| M | HIS359 |
| N | SER474 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| I | TYR192-HIS198 | |
| J | TYR200-HIS206 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10731668, ECO:0000269|PubMed:12297049, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:20837704, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1MOX, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2U, ECO:0007744|PDB:3B2V, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3P0Y, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRL, ECO:0007744|PDB:4KRM, ECO:0007744|PDB:4KRO, ECO:0007744|PDB:4KRP, ECO:0007744|PDB:4UIP, ECO:0007744|PDB:4UV7 |
| Chain | Residue | Details |
| M | ASP328 | |
| N | ASP328 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10731668, ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2U, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRL, ECO:0007744|PDB:4KRM, ECO:0007744|PDB:4KRO, ECO:0007744|PDB:4KRP, ECO:0007744|PDB:4UV7 |
| Chain | Residue | Details |
| M | ASN337 | |
| N | ASN337 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:8962717, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2U, ECO:0007744|PDB:3B2V, ECO:0007744|PDB:3P0Y, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRO, ECO:0007744|PDB:4KRP |
| Chain | Residue | Details |
| M | ASN389 | |
| N | ASN389 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12297050, ECO:0000269|PubMed:12620237, ECO:0000269|PubMed:12731890, ECO:0000269|PubMed:16083266, ECO:0000269|PubMed:20837704, ECO:0000269|PubMed:8962717, ECO:0007744|PDB:1IVO, ECO:0007744|PDB:1NQL, ECO:0007744|PDB:1YY9, ECO:0007744|PDB:3B2U, ECO:0007744|PDB:3B2V, ECO:0007744|PDB:3NJP, ECO:0007744|PDB:3P0Y, ECO:0007744|PDB:3QWQ, ECO:0007744|PDB:4KRL, ECO:0007744|PDB:4KRM, ECO:0007744|PDB:4KRO, ECO:0007744|PDB:4KRP, ECO:0007744|PDB:4UIP, ECO:0007744|PDB:4UV7 |
| Chain | Residue | Details |
| M | ASP420 | |
| N | ASP420 |
