PDB: 331 件ウェブページステータス検索Chemie searchBIRD

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5E18	T. thermophilus transcription initiation complex having a YYY discriminator sequence and a nontemplate-strand length corresponding to TSS selection at position 8 (RPo-CCC-8) 分子名称: DNA (28-MER), DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Zhang, Y, Ebright, R.H. 登録日 2015-09-29 公開日 2016-03-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Multiplexed protein-DNA cross-linking: Scrunching in transcription start site selection. Science, 351, 2016
5E17	T. thermophilus transcription initiation complex having a RRR discriminator sequence and a nontemplate-strand length corresponding to TSS selection at position 7 (RPo-GGG-7) 分子名称: DNA (27-MER), DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Zhang, Y, Ebright, R.H. 登録日 2015-09-29 公開日 2016-03-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Multiplexed protein-DNA cross-linking: Scrunching in transcription start site selection. Science, 351, 2016
5D4D	Crystal structure of Thermus thermophilus product complex for transcription initiation with NAD and CTP 分子名称: ADENOSINE MONOPHOSPHATE, CYTIDINE-5'-MONOPHOSPHATE, CYTIDINE-5'-TRIPHOSPHATE, ... 著者 Zhang, Y, Ebright, R.H. 登録日 2015-08-07 公開日 2016-07-06 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA. Nature, 535, 2016
5D4C	Crystal structure of Thermus thermophilus product complex for transcription initiation with ATP and CTP 分子名称: ADENOSINE-5'-TRIPHOSPHATE, CYTIDINE-5'-MONOPHOSPHATE, CYTIDINE-5'-TRIPHOSPHATE, ... 著者 Zhang, Y, Ebright, R.H. 登録日 2015-08-07 公開日 2016-07-06 最終更新日 2024-07-03 実験手法 X-RAY DIFFRACTION (3.28 Å) 主引用文献 The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA. Nature, 535, 2016
5D4E	Crystal structure of Thermus thermophilus product complex for transcription initiation with 3'-dephosphate-CoA and CTP 分子名称: CYTIDINE-5'-MONOPHOSPHATE, DEPHOSPHO COENZYME A, DIPHOSPHATE, ... 著者 Zhang, Y, Ebright, R.H. 登録日 2015-08-07 公開日 2016-07-06 最終更新日 2024-07-03 実験手法 X-RAY DIFFRACTION (3.08 Å) 主引用文献 The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA. Nature, 535, 2016
4ZH2	Crystal structure of Escherichia coli RNA polymerase in complex with CBR703 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Feng, Y, Ebright, R.H. 登録日 2015-04-24 公開日 2015-08-05 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (4.204 Å) 主引用文献 Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles. Structure, 23, 2015
4ZH3	Crystal structure of Escherichia coli RNA polymerase in complex with CBRH16-Br 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Feng, Y, Ebright, R.H. 登録日 2015-04-24 公開日 2015-08-05 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (4.082 Å) 主引用文献 Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles. Structure, 23, 2015
4ZH4	Crystal structure of Escherichia coli RNA polymerase in complex with CBRP18 分子名称: 5-(4-fluorophenyl)-4-[4-fluoro-3-(trifluoromethyl)phenyl]-1H-pyrazole, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Feng, Y, Ebright, R.H. 登録日 2015-04-24 公開日 2015-08-05 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.993 Å) 主引用文献 Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles. Structure, 23, 2015
4YLP	E. coli Transcription Initiation Complex - 16-bp spacer and 5-nt RNA 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Zuo, Y, Steitz, T.A. 登録日 2015-03-05 公開日 2015-04-22 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (5.5 Å) 主引用文献 Crystal Structures of the E. coli Transcription Initiation Complexes with a Complete Bubble. Mol.Cell, 58, 2015
4YLO	E. coli Transcription Initiation Complex - 16-bp spacer and 4-nt RNA 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Zuo, Y, Steitz, T.A. 登録日 2015-03-05 公開日 2015-04-22 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (6 Å) 主引用文献 Crystal Structures of the E. coli Transcription Initiation Complexes with a Complete Bubble. Mol.Cell, 58, 2015
4YLN	E. coli Transcription Initiation Complex - 17-bp spacer and 4-nt RNA 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Zuo, Y, Steitz, T.A. 登録日 2015-03-05 公開日 2015-04-22 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (5.5 Å) 主引用文献 Crystal Structures of the E. coli Transcription Initiation Complexes with a Complete Bubble. Mol.Cell, 58, 2015
4YG2	X-ray crystal structur of Escherichia coli RNA polymerase sigma70 holoenzyme 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Murakami, K.S. 登録日 2015-02-25 公開日 2015-03-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 X-ray crystal structure of Escherichia coli RNA polymerase sigma70 holoenzyme J. Biol. Chem., 288, 2013
4YFX	Escherichia coli RNA polymerase in complex with Myxopyronin B 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Molodtsov, V, Fleming, P.R, Eyermann, C.J, Ferguson, A.D, Foulk, M.A, McKinney, D.C, Masse, C.E, Buurman, E.T, Murakami, K.S. 登録日 2015-02-25 公開日 2015-03-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.844 Å) 主引用文献 X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein. J.Med.Chem., 58, 2015
4YFK	Escherichia coli RNA polymerase in complex with squaramide compound 8. 分子名称: 3,5-dimethyl-N-{2-[4-(4-methylbenzyl)piperidin-1-yl]-3,4-dioxocyclobut-1-en-1-yl}-1,2-oxazole-4-sulfonamide, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Molodtsov, V, Fleming, P.R, Eyermann, C.J, Ferguson, A.D, Foulk, M.A, McKinney, D.C, Masse, C.E, Buurman, E.T, Murakami, K.S. 登録日 2015-02-25 公開日 2015-03-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.571 Å) 主引用文献 X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein. J.Med.Chem., 58, 2015
4YFN	Escherichia coli RNA polymerase in complex with squaramide compound 14 (N-[3,4-dioxo-2-(4-{[4-(trifluoromethyl)benzyl]amino}piperidin-1-yl)cyclobut-1-en-1-yl]-3,5-dimethyl-1,2-oxazole-4-sulfonamide) 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Molodtsov, V, Fleming, P.R, Eyermann, C.J, Ferguson, A.D, Foulk, M.A, McKinney, D.C, Masse, C.E, Buurman, E.T, Murakami, K.S. 登録日 2015-02-25 公開日 2015-03-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.817 Å) 主引用文献 X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein. J.Med.Chem., 58, 2015
4XSZ	Crystal structure of CBR 9393 bound to Escherichia coli RNA polymerase holoenzyme 分子名称: 4-[3-(4-fluorophenyl)-1H-pyrazol-4-yl]-N-[2-(piperazin-1-yl)ethyl]-2-(trifluoromethyl)aniline, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Bae, B, Darst, S.A. 登録日 2015-01-22 公開日 2015-07-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.683 Å) 主引用文献 CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition. Proc.Natl.Acad.Sci.USA, 112, 2015
4XSX	Crystal structure of CBR 703 bound to Escherichia coli RNA polymerase holoenzyme 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Bae, B, Darst, S.A. 登録日 2015-01-22 公開日 2015-07-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.708 Å) 主引用文献 CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition. Proc.Natl.Acad.Sci.USA, 112, 2015
4XSY	Crystal structure of CBR 9379 bound to Escherichia coli RNA polymerase holoenzyme 分子名称: 3-{[(2,6-dichlorophenyl)carbamoyl]amino}-N-hydroxy-N'-phenyl-5-(trifluoromethyl)benzenecarboximidamide, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Bae, B, Darst, S.A. 登録日 2015-01-22 公開日 2015-07-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (4.007 Å) 主引用文献 CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition. Proc.Natl.Acad.Sci.USA, 112, 2015
4XLS	Crystal structure of T. aquaticus transcription initiation complex with CarD containing upstream fork promoter. 分子名称: CarD-like transcriptional regulator, DNA (30-MER), DNA (5'-D(P*GP*CP*AP*CP*AP*AP*TP*TP*TP*AP*AP*CP*AP*CP*TP*TP*TP*TP*GP*TP*CP*AP*AP*G)-3'), ... 著者 Bae, B, Darst, S.A. 登録日 2015-01-13 公開日 2015-09-23 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (4.01 Å) 主引用文献 CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex. Elife, 4, 2015
4XLQ	Crystal structure of T.aquaticus transcription initiation complex containing upstream fork (-11 base-paired) promoter 分子名称: DNA (26-MER), DNA (30-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Bae, B, Darst, S.A. 登録日 2015-01-13 公開日 2015-09-23 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (4.6 Å) 主引用文献 Structure of a bacterial RNA polymerase holoenzyme open promoter complex. Elife, 4, 2015
4XLP	Crystal structure of T.aquaticus transcription initiation complex containing upstream fork promoter 分子名称: DNA (25-MER), DNA (30-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Bae, B, Darst, S.A. 登録日 2015-01-13 公開日 2015-09-23 最終更新日 2019-12-25 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 Structure of a bacterial RNA polymerase holoenzyme open promoter complex. Elife, 4, 2015
4XLR	Crystal structure of T.aquaticus transcription initiation complex with CarD containing bubble promoter and RNA 分子名称: CarD-like transcriptional regulator, DNA (48-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Bae, B, Darst, S.A. 登録日 2015-01-13 公開日 2015-09-23 最終更新日 2017-11-22 実験手法 X-RAY DIFFRACTION (4.3 Å) 主引用文献 CarD uses a minor groove wedge mechanism to stabilize the RNA polymerase open promoter complex. Elife, 4, 2015
4XLN	Crystal structure of T. aquaticus transcription initiation complex containing bubble promoter and RNA 分子名称: DNA (48-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Bae, B, Darst, S.A. 登録日 2015-01-13 公開日 2015-09-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 Structure of a bacterial RNA polymerase holoenzyme open promoter complex. Elife, 4, 2015
4X8K	Mycobacterium tuberculosis RbpA-SID in complex with SigmaA domain 2 分子名称: 1,2-ETHANEDIOL, RNA polymerase sigma factor SigA, RNA polymerase-binding protein RbpA, ... 著者 Hubin, E.A, Flack, J.E, Tabib-Salazar, A, Paget, M.S, Darst, S.A, Campbell, E.A. 登録日 2014-12-10 公開日 2015-06-03 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.202 Å) 主引用文献 Structural, functional, and genetic analyses of the actinobacterial transcription factor RbpA. Proc.Natl.Acad.Sci.USA, 112, 2015
4Q5S	Thermus thermophilus RNA polymerase initially transcribing complex containing 6-mer RNA 分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*GP*CP*AP*GP*CP*CP*A)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3'), ... 著者 Murakami, K.S. 登録日 2014-04-17 公開日 2014-07-09 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme. J.Biol.Chem., 289, 2014

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