Crystal structure of CBR 703 bound to Escherichia coli RNA polymerase holoenzyme

Summary for 4XSX

Related4XSZ 4XSY
DescriptorDNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... (8 entities in total)
Functional Keywordsbacterial rna polymerase antibiotic complex, transcription-antibiotic complex, transcription/antibiotic
Biological sourceEscherichia coli (strain K12)
Cellular locationCytoplasm  P00579
Total number of polymer chains12
Total molecular weight860212.15
Bae, B.,Darst, S.A. (deposition date: 2015-01-22, release date: 2015-07-22, Last modification date: 2017-11-22)
Primary citation
Bae, B.,Nayak, D.,Ray, A.,Mustaev, A.,Landick, R.,Darst, S.A.
CBR antimicrobials inhibit RNA polymerase via at least two bridge-helix cap-mediated effects on nucleotide addition.
Proc.Natl.Acad.Sci.USA, 112:E4178-E4187, 2015
PubMed: 26195788 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.1502368112
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.27311 0.4% 9.4% 2.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-11-18