PDB: 507 件ウェブページステータス検索Chemie searchBIRD

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1GQR	ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH RIVASTIGMINE 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[(1S)-1-(DIMETHYLAMINO)ETHYL]PHENOL, ACETYLCHOLINESTERASE, ... 著者 Raves, M.L, Harel, M, Silman, I, Sussman, J.L. 登録日 2001-12-04 公開日 2002-03-15 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Kinetic and Structural Studies on the Interaction of Cholinesterases with the Anti-Alzheimer Drug Rivastigmine Biochemistry, 41, 2002
1H23	Structure of acetylcholinesterase (E.C. 3.1.1.7) complexed with (S,S)-(-)-bis(12)-hupyridone at 2.15A resolution 分子名称: (S,S)-(-)-N,N'-DI-5'-[5',6',7',8'-TETRAHYDRO- 2'(1'H)-QUINOLYNYL]-1,12-DIAMINODODECANE DIHYDROCHLORIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE 著者 Wong, D.M, Greenblatt, H.M, Carlier, P.R, Han, Y.F, Pang, Y.P, Silman, I, Sussman, J.L. 登録日 2002-07-30 公開日 2002-12-23 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity J.Am.Chem.Soc., 125, 2003
1GPK	Structure of Acetylcholinesterase Complex with (+)-Huperzine A at 2.1A Resolution 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE, ... 著者 Dvir, H, Harel, M, Chetrit, M, Silman, I, Sussman, J.L. 登録日 2001-11-05 公開日 2002-08-29 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 X-Ray Structures of Torpedo Californica Acetylcholinesterase Complexed with (+)-Huperzine a and (-)-Huperzine B: Structural Evidence for an Active Site Rearrangement Biochemistry, 41, 2002
1XLU	X-Ray Structure Of Di-Isopropyl-Phosphoro-Fluoridate (Dfp) Inhibited Butyrylcholinesterase after Aging 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Nachon, F, Asojo, O.A, Borgstahl, G.E.O, Masson, P, Lockridge, O. 登録日 2004-09-30 公開日 2005-02-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.198 Å) 主引用文献 Role of Water in Aging of Human Butyrylcholinesterase Inhibited by Echothiophate: The Crystal Structure Suggests Two Alternative Mechanisms of Aging Biochemistry, 44, 2005
1GZ7	Crystal structure of the closed state of lipase 2 from Candida rugosa 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, LIPASE 2 著者 Mancheno, J.M, Hermoso, J.A. 登録日 2002-05-17 公開日 2003-06-12 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Structural Insights Into the Lipase/Esterase Behavior in the Candida Rugosa Lipases Family: Crystal Structure of the Lipase 2 Isoenzyme at 1.97A Resolution J.Mol.Biol., 332, 2003
2ACE	NATIVE ACETYLCHOLINESTERASE (E.C. 3.1.1.7) FROM TORPEDO CALIFORNICA 分子名称: ACETYLCHOLINE, ACETYLCHOLINESTERASE 著者 Harel, M, Raves, M.L, Silman, I, Sussman, J.L. 登録日 1996-06-23 公開日 1996-11-08 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A. Nat.Struct.Biol., 4, 1997
1GQS	ACETYLCHOLINESTERASE (E.C. 3.1.1.7) COMPLEXED WITH NAP 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[(1S)-1-(DIMETHYLAMINO)ETHYL]PHENOL, ACETYLCHOLINESTERASE 著者 Bar-on, P, Millard, C.B, Harel, M, Dvir, H, Enz, A, Sussman, J.L, Silman, I. 登録日 2001-12-04 公開日 2002-03-15 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Kinetic and Structural Studies on the Interaction of Cholinesterases with the Anti-Alzheimer Drug Rivastigmine Biochemistry, 41, 2002
1HBJ	X-ray Crystal structure of complex between Torpedo californica AChE and a reversible inhibitor, 4-Amino-5-fluoro-2-methyl-3-(3-trifluoroacetylbenzylthiomethyl)quinoline 分子名称: 1-[3-({[(4-AMINO-5-FLUORO-2-METHYLQUINOLIN-3-YL)METHYL]THIO}METHYL)PHENYL]-2,2,2-TRIFLUOROETHANE-1,1-DIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Greenblatt, H.M, Kryger, G, Lewis, T.L, Doucet, C, Viner, R, Silman, I, Sussman, J.L. 登録日 2001-04-16 公開日 2001-09-25 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 A Structure-Based Design Approach to the Development of Novel, Reversible Ache Inhibitors J.Med.Chem., 44, 2001
1ZGC	Crystal Structure of Torpedo Californica Acetylcholinesterase in Complex With an (RS)-Tacrine(10)-Hupyridone Inhibitor. 分子名称: (5S)-5-{[10-(1,2,3,4-TETRAHYDROACRIDIN-9-YLAMINO)DECYL]AMINO}-5,6,7,8-TETRAHYDROQUINOLIN-2(1H)-ONE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase 著者 Haviv, H, Wong, D.M, Greenblatt, H.M, Carlier, P.R, Pang, Y.P, Silman, I, Sussman, J.L, Israel Structural Proteomics Center (ISPC) 登録日 2005-04-21 公開日 2005-08-16 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Packing Mediates Enantioselective Ligand Recognition at the Peripheral Site of Acetylcholinesterase J.Am.Chem.Soc., 127, 2005
1H22	Structure of acetylcholinesterase (E.C. 3.1.1.7) complexed with (S,S)-(-)-bis(10)-hupyridone at 2.15A resolution 分子名称: (S,S)-(-)-N,N'-DI-5'-[5',6',7',8'-TETRAHYDRO- 2'(1'H)-QUINOLYNYL]-1,10-DIAMINODECANE DIHYDROCHLORIDE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE 著者 Wong, D.M, Greenblatt, H.M, Carlier, P.R, Han, Y.-F, Pang, Y.-P, Silman, I, Sussman, J.L. 登録日 2002-07-30 公開日 2002-12-23 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Acetylcholinesterase Complexed with Bivalent Ligands Related to Huperzine A: Experimental Evidence for Species-Dependent Protein-Ligand Complementarity J.Am.Chem.Soc., 125, 2003
1F6W	STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN BILE SALT ACTIVATED LIPASE 分子名称: BILE SALT ACTIVATED LIPASE 著者 Terzyan, S, Zhang, X. 登録日 2000-06-23 公開日 2000-10-18 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of the catalytic domain of human bile salt activated lipase. Protein Sci., 9, 2000
1XLV	Ethylphosphorylated Butyrylcholinesterase (Aged) Obtained By Reaction With Echothiophate 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Nachon, F, Asojo, O.A, Borgstahl, G.E.O, Masson, P, Lockridge, O. 登録日 2004-09-30 公開日 2005-02-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.247 Å) 主引用文献 Role of Water in Aging of Human Butyrylcholinesterase Inhibited by Echothiophate: The Crystal Structure Suggests Two Alternative Mechanisms of Aging Biochemistry, 44, 2005
1YA4	Crystal Structure of Human Liver Carboxylesterase 1 in complex with tamoxifen 分子名称: (Z)-2-[4-(1,2)-DIPHENYL-1-BUTENYL)-PHENOXY]-N,N-DIMETHYLETHANAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CES1 protein, ... 著者 Fleming, C.D, Bencharit, S, Edwards, C.C, Hyatt, J.L, Morton, C.L, Howard-Williams, E.L, Potter, P.M, Redinbo, M.R. 登録日 2004-12-17 公開日 2005-08-02 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil. J.Mol.Biol., 352, 2005
1YAJ	Crystal Structure of Human Liver Carboxylesterase in complex with benzil 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, BENZOIC ACID, CES1 protein, ... 著者 Fleming, C.D, Bencharit, S, Edwards, C.C, Hyatt, J.L, Morton, C.M, Howard-Williams, E.L, Potter, P.M, Redinbo, M.R. 登録日 2004-12-17 公開日 2005-08-02 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil. J.Mol.Biol., 352, 2005
1YAH	Crystal Structure of Human Liver Carboxylesterase complexed to Etyl Acetate; A Fatty Acid Ethyl Ester Analogue 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CES1 protein, ETHYL ACETATE, ... 著者 Fleming, C.D, Bencahrit, S, Edwards, C.C, Hyatt, J.L, Morton, C.L, Howard-Williams, E.L, Potter, P.M, Redinbo, M.R. 登録日 2004-12-17 公開日 2005-08-02 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil. J.Mol.Biol., 352, 2005
2ACK	ACETYLCHOLINESTERASE COMPLEXED WITH EDROPHONIUM, MONOCHROMATIC DATA 分子名称: ACETYLCHOLINESTERASE, EDROPHONIUM ION 著者 Raves, M.L, Sussman, J.L, Harel, M, Silman, I. 登録日 1997-10-29 公開日 1998-02-11 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Static Laue diffraction studies on acetylcholinesterase. Acta Crystallogr.,Sect.D, 54, 1998
1XLW	Diethylphosphorylated Butyrylcholinesterase (Nonaged) Obtained By Reaction With Echothiophate 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Nachon, F, Asojo, O.A, Borgstahl, G.E.O, Masson, P, Lockridge, O. 登録日 2004-09-30 公開日 2005-02-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Role of Water in Aging of Human Butyrylcholinesterase Inhibited by Echothiophate: The Crystal Structure Suggests Two Alternative Mechanisms of Aging Biochemistry, 44, 2005
1YA8	Crystal Structure of Human Liver Carboxylesterase in complex with cleavage products of Mevastatin 分子名称: (1S,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-7-METHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HY DROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENOL, 2-METHYLBUTANOIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Fleming, C.D, Bencharit, S, Edwards, C.C, Hyatt, J.L, Morton, C.L, Howard-Williams, E.L, Potter, P.M, Redinbo, M.R. 登録日 2004-12-17 公開日 2005-08-02 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil. J.Mol.Biol., 352, 2005
1EVE	THREE DIMENSIONAL STRUCTURE OF THE ANTI-ALZHEIMER DRUG, E2020 (ARICEPT), COMPLEXED WITH ITS TARGET ACETYLCHOLINESTERASE 分子名称: 1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL)METHYL]PIPERIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Kryger, G, Silman, I, Sussman, J.L. 登録日 1998-03-04 公開日 1999-01-20 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs. Structure Fold.Des., 7, 1999
1EEA	Acetylcholinesterase 分子名称: PROTEIN (ACETYLCHOLINESTERASE) 著者 Raves, M.L, Giles, K, Schrag, J.D, Schmid, M.F, Phillips Jr, G.N, Wah, C, Howard, A.J, Silman, I, Sussman, J.L. 登録日 1999-01-26 公開日 1999-02-01 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (4.5 Å) 主引用文献 Quaternary Structure of Tetrameric Acetylcholinesterase Structure and Function of Cholinesterases and Related Proteins, 1998
1E66	STRUCTURE OF ACETYLCHOLINESTERASE COMPLEXED WITH (-)-HUPRINE X AT 2.1A RESOLUTION 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-CHLORO-9-ETHYL-6,7,8,9,10,11-HEXAHYDRO-7,11-METHANOCYCLOOCTA[B]QUINOLIN-12-AMINE, ACETYLCHOLINESTERASE 著者 Dvir, H, Harel, M, Silman, I, Sussman, J.L. 登録日 2000-08-08 公開日 2001-08-02 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 3D Structure of Torpedo Californica Acetylcholinesterase Complexed with Huprine X at 2. 1 A Resolution: Kinetic and Molecular Dynamic Correlates. Biochemistry, 41, 2002
2BAG	3D Structure of Torpedo californica acetylcholinesterase complexed with Ganstigmine 分子名称: 1S,3AS,8AS-TRIMETHYL-1-OXIDO-1,2,3,3A,8,8A-HEXAHYDROPYRROLO[2,3-B]INDOL-5-YL 2-ETHYLPHENYLCARBAMATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Lamba, D, Bartolucci, C, Siotto, M, Racchi, M, Villetti, G, Delcanale, M. 登録日 2005-10-14 公開日 2006-08-29 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural Determinants of Torpedo californica Acetylcholinesterase Inhibition by the Novel and Orally Active Carbamate Based Anti-Alzheimer Drug Ganstigmine (CHF-2819) J.Med.Chem., 49, 2006
1J07	Crystal structure of the mouse acetylcholinesterase-decidium complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,8-DIAMINO-5,10'-(TRIMETHYLAMMONIUM)DECYL-6-PHENYL PHENANTHRIDINIUM, CARBONATE ION, ... 著者 Bourne, Y, Taylor, P, Radic, Z, Marchot, P. 登録日 2002-11-07 公開日 2003-02-04 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site EMBO J., 22, 2003
2BCE	CHOLESTEROL ESTERASE FROM BOS TAURUS 分子名称: CHOLESTEROL ESTERASE 著者 Chen, J.C.-H, Miercke, L.J.W, Krucinski, J, Starr, J.R, Saenz, G, Wang, X, Spilburg, C.A, Lange, L.G, Ellsworth, J.L, Stroud, R.M. 登録日 1998-01-28 公開日 1999-02-02 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure of bovine pancreatic cholesterol esterase at 1.6 A: novel structural features involved in lipase activation. Biochemistry, 37, 1998
1EA5	NATIVE ACETYLCHOLINESTERASE (E.C. 3.1.1.7) FROM TORPEDO CALIFORNICA at 1.8A resolution 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE 著者 Harel, M, Weik, M, Silman, I, Sussman, J.L. 登録日 2000-11-06 公開日 2000-11-08 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 X-Ray Structures of Torpedo Californica Acetylcholinesterase Complexed with (+)-Huperzine a and (-)-Huperzine B: Structural Evidence for an Active Site Rearrangement Biochemistry, 41, 2002

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