1YAJ

Crystal Structure of Human Liver Carboxylesterase in complex with benzil

Summary for 1YAJ

Entry DOI	10.2210/pdb1yaj/pdb
Related	1MX1 1MX5 1MX9 1ya4 1ya8 1yah
Descriptor	CES1 protein, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetyl-alpha-neuraminic acid, ... (6 entities in total)
Functional Keywords	hydrolase, carboxylesterase, benzil, inhibition
Biological source	Homo sapiens (human)
Total number of polymer chains	12
Total formula weight	715668.88
Authors	Fleming, C.D.,Bencharit, S.,Edwards, C.C.,Hyatt, J.L.,Morton, C.M.,Howard-Williams, E.L.,Potter, P.M.,Redinbo, M.R. (deposition date: 2004-12-17, release date: 2005-08-02, Last modification date: 2023-08-23)
Primary citation	Fleming, C.D.,Bencharit, S.,Edwards, C.C.,Hyatt, J.L.,Tsurkan, L.,Bai, F.,Fraga, C.,Morton, C.L.,Howard-Williams, E.L.,Potter, P.M.,Redinbo, M.R. Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil. J.Mol.Biol., 352:165-177, 2005 Cited by PubMed: 16081098 DOI: 10.1016/j.jmb.2005.07.016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation