2BAG

3D Structure of Torpedo californica acetylcholinesterase complexed with Ganstigmine

Summary for 2BAG

• Entry DOI: 10.2210/pdb2bag/pdb
• Related: 1EA5 1GQR 1GQS 1OCE
• Descriptor: Acetylcholinesterase, 2-acetamido-2-deoxy-beta-D-glucopyranose, PENTAETHYLENE GLYCOL, ... (6 entities in total)
• Functional Keywords: serine hydrolase, cholinesterase, neurotransmitter cleavage, anti-alzheimer drug, hydrolase
• Biological source: Torpedo californica (Pacific electric ray)
• Cellular location: Isoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058
• Total number of polymer chains: 1
• Total formula weight: 62777.73

Authors

Lamba, D.,Bartolucci, C.,Siotto, M.,Racchi, M.,Villetti, G.,Delcanale, M. (deposition date: 2005-10-14, release date: 2006-08-29, Last modification date: 2023-10-25)

• Primary citation: Bartolucci, C.,Siotto, M.,Ghidini, E.,Amari, G.,Bolzoni, P.T.,Racchi, M.,Villetti, G.,Delcanale, M.,Lamba, D.; Structural Determinants of Torpedo californica Acetylcholinesterase Inhibition by the Novel and Orally Active Carbamate Based Anti-Alzheimer Drug Ganstigmine (CHF-2819); J.Med.Chem., 49:5051-5058, 2006; PubMed: 16913695; DOI: 10.1021/jm060293s

Experimental method

X-RAY DIFFRACTION (2.4 Å)