5APP
 
 | | Actinobacillus actinomycetemcomitans OMP100 residues 133-198 fused to GCN4 adaptors | | 分子名称: | CHLORIDE ION, General control protein GCN4,GENERAL CONTROL PROTEIN GCN4, OUTER MEMBRANE PROTEIN 100,General control protein GCN4 | | 著者 | Hartmann, M.D, Ridderbusch, O, Lupas, A.N, Hernandez Alvarez, B. | | 登録日 | 2015-09-17 | | 公開日 | 2016-01-27 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | alpha / beta coiled coils.
Elife, 5, 2016
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7QB1
 | | PPARg in complex with inhibitor | | 分子名称: | 3-[(3,4-dichlorophenyl)methyl]-4-oxidanylidene-6-phenoxy-phthalazine-1-carboxylic acid, Peroxisome proliferator-activated receptor gamma, SULFATE ION | | 著者 | Petersen, J. | | 登録日 | 2021-11-17 | | 公開日 | 2022-05-04 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Discovery by Virtual Screening of an Inhibitor of CDK5-Mediated PPAR gamma Phosphorylation.
Acs Med.Chem.Lett., 13, 2022
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5BPU
 | | Crystal structure of Norrin, a Wnt signalling activator, Crystal Form I | | 分子名称: | (GGL)EEE, (GGL)EEEEEE, Norrin | | 著者 | Chang, T.-H, Hsieh, F.-L, Harlos, K, Jones, E.Y. | | 登録日 | 2015-05-28 | | 公開日 | 2015-07-01 | | 最終更新日 | 2019-07-10 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan.
Elife, 4, 2015
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5BQB
 | | Crystal structure of Norrin, a Wnt signalling activator, Crystal Form III | | 分子名称: | CHLORIDE ION, CITRIC ACID, Norrin | | 著者 | Chang, T.-H, Hsieh, F.-L, Harlos, K, Jones, E.Y. | | 登録日 | 2015-05-28 | | 公開日 | 2015-07-01 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan.
Elife, 4, 2015
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1H4X
 | | Structure of the Bacillus Cell Fate Determinant SpoIIAA in the Phosphorylated Form | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ANTI-SIGMA F FACTOR ANTAGONIST | | 著者 | Seavers, P.R, Lewis, R.J, Brannigan, J.A, Verschueren, K.H.G, Murshudov, G.N, Wilkinson, A.J. | | 登録日 | 2001-05-15 | | 公開日 | 2001-07-06 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.16 Å) | | 主引用文献 | Structure of the Bacillus Cell Fate Determinant Spoiiaa in Phosphorylated and Unphosphorylated Forms
Structure, 9, 2001
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7QP4
 | | Complex of a Gemini-cholesterol analogue with Retinoid-related Orphan Receptor gamma | | 分子名称: | (3~{S},8~{S},9~{S},10~{R},13~{R},14~{S},17~{R})-17-[(6~{R})-2,10-dimethyl-2-oxidanyl-undecan-6-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1~{H}-cyclopenta[a]phenanthren-3-ol, ACETATE ION, HIS-VAL-GLU-ARG-LEU-GLN-ILE-PHE-GLN-HIS-LEU-HIS-PRO-ILE-VAL, ... | | 著者 | Rochel, N. | | 登録日 | 2022-01-02 | | 公開日 | 2022-12-14 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Development of novel Gemini-cholesterol analogues for retinoid-related orphan receptors
Org Chem Front, 9, 2022
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4HP7
 | | Trioxacarcin D517 as a product of guanine robbery from d(AACCGGTT) | | 分子名称: | DIMETHYL SULFOXIDE, GUANINE, Trioxacarcin A analogue, ... | | 著者 | Smaltz, D.J, Magauer, T, Proepper, K, Dittrich, B, Myers, A.G. | | 登録日 | 2012-10-23 | | 公開日 | 2013-10-23 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.09 Å) | | 主引用文献 | Trioxacarcin D517
TO BE PUBLISHED
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5C1Q
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1GTN
 | | Structure of the trp RNA-binding attenuation protein (TRAP) bound to an RNA molecule containing 11 GAGCC repeats | | 分子名称: | (GAGCC)11G 56-NUCLEOTIDE RNA, TRP RNA-BINDING ATTENUATION PROTEIN, TRYPTOPHAN | | 著者 | Hopcroft, N.H, Wendt, A.L, Gollnick, P, Antson, A.A. | | 登録日 | 2002-01-16 | | 公開日 | 2002-04-05 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Specificity of Trap-RNA Interactions: Crystal Structures of Two Complexes with Different RNA Sequences
Acta Crystallogr.,Sect.D, 58, 2002
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7QPP
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5C31
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5CL1
 | | Complex structure of Norrin with human Frizzled 4 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-4, Maltose-binding periplasmic protein,Norrin | | 著者 | Wang, Z, Ke, J, Shen, G, Cheng, Z, Xu, H.E, Xu, W. | | 登録日 | 2015-07-16 | | 公開日 | 2015-08-12 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | | 主引用文献 | Structural basis of the Norrin-Frizzled 4 interaction.
Cell Res., 25, 2015
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1VYW
 | | Structure of CDK2/Cyclin A with PNU-292137 | | 分子名称: | CELL DIVISION PROTEIN KINASE 2, CYCLIN A2, N-(3-CYCLOPROPYL-1H-PYRAZOL-5-YL)-2-(2-NAPHTHYL)ACETAMIDE, ... | | 著者 | Pevarello, P, Brasca, M.G, Amici, R, Orsini, P, Traquandi, G, Corti, L, Piutti, C, Sansonna, P, Villa, M, Pierce, B.S, Pulici, M, Giordano, P, Martina, K, Fritzen, E.L, Nugent, R.A, Casale, E, Cameron, A, Ciomei, M, Roletto, F, Isacchi, A, Fogliatto, G, Pesenti, E, Pastori, W, Marsiglio, A, Leach, K.L, Clare, P.M, Fiorentini, F, Varasi, M, Vulpetti, A, Warpehoski, M.A. | | 登録日 | 2004-05-07 | | 公開日 | 2004-06-10 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | 3-Aminopyrazole Inhibitors of Cdk2/Cyclin a as Antitumor Agents. Part 1. Lead Finding
J.Med.Chem., 47, 2004
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1H4Z
 | | Structure of the Anti-Sigma Factor Antagonist SpoIIAA in its Unphosphorylated Form | | 分子名称: | ANTI-SIGMA F FACTOR ANTAGONIST | | 著者 | Seavers, P.R, Lewis, R.J, Brannigan, J.A, Verschueren, K.H.G, Murshudov, G.N, Wilkinson, A.J. | | 登録日 | 2001-05-16 | | 公開日 | 2001-07-06 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | | 主引用文献 | Structure of the Bacillus Cell Fate Determinant Spoiiaa in Phosphorylated and Unphosphorylated Forms
Structure, 9, 2001
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1H4Y
 | | Structure of the Anti-Sigma Factor Antagonist SpoIIAA in its Unphosphorylated Form | | 分子名称: | ANTI-SIGMA F FACTOR ANTAGONIST | | 著者 | Seavers, P.R, Lewis, R.J, Brannigan, J.A, Verschueren, K.H.G, Murshudov, G.N, Wilkinson, A.J. | | 登録日 | 2001-05-16 | | 公開日 | 2001-07-06 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | | 主引用文献 | Structure of the Bacillus Cell Fate Determinant Spoiiaa in Phosphorylated and Unphosphorylated Forms
Structure, 9, 2001
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7D8C
 | | Crystal structure of the Cas12i1-crRNA binary complex | | 分子名称: | 12i1, CITRIC ACID, RNA (3-MER), ... | | 著者 | Zhang, B, Luo, D.Y, Li, Y, OuYang, S.Y. | | 登録日 | 2020-10-07 | | 公開日 | 2021-05-19 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Mechanistic insights into the R-loop formation and cleavage in CRISPR-Cas12i1.
Nat Commun, 12, 2021
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5C25
 | | Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 6-((4-((4-cyanophenyl)amino)-1,3,5-triazin-2-yl)amino)-5,7-dimethyl-2-naphthonitrile (JLJ639), a Non-nucleoside Inhibitor | | 分子名称: | 6-({4-[(4-cyanophenyl)amino]-1,3,5-triazin-2-yl}amino)-5,7- dimethyl-2-naphthonitrile, HIV-1 REVERSE TRANSCRIPTASE, P51 SUBUNIT, ... | | 著者 | Chan, A.H, Frey, K.M, Anderson, K.S. | | 登録日 | 2015-06-15 | | 公開日 | 2015-07-29 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.841 Å) | | 主引用文献 | Discovery and crystallography of bicyclic arylaminoazines as potent inhibitors of HIV-1 reverse transcriptase.
Bioorg.Med.Chem.Lett., 25, 2015
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7RIO
 | | human PXR LBD bound to GSK003 | | 分子名称: | Isoform 1C of Nuclear receptor subfamily 1 group I member 2, N-[3-(2-tert-butyl-5-{2-[2-(methanesulfonyl)ethyl]pyrimidin-4-yl}-1,3-thiazol-4-yl)-2-fluorophenyl]-2,5-difluorobenzene-1-sulfonamide | | 著者 | Williams, S.P, Wisely, G.B, Ward, P. | | 登録日 | 2021-07-20 | | 公開日 | 2021-08-25 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | | 主引用文献 | Overcoming the Pregnane X Receptor Liability: Rational Design to Eliminate PXR-Mediated CYP Induction.
Acs Med.Chem.Lett., 12, 2021
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7RIV
 | | human PXR LBD bound to GSK001 | | 分子名称: | Dabrafenib, Isoform 1C of Nuclear receptor subfamily 1 group I member 2 | | 著者 | Williams, S.P, Wisely, G.B, Ward, P. | | 登録日 | 2021-07-20 | | 公開日 | 2021-08-25 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Overcoming the Pregnane X Receptor Liability: Rational Design to Eliminate PXR-Mediated CYP Induction.
Acs Med.Chem.Lett., 12, 2021
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7RIU
 | | human PXR LBD bound to GSK002 | | 分子名称: | Isoform 1C of Nuclear receptor subfamily 1 group I member 2, N-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}thiophene-3-sulfonamide | | 著者 | Williams, S.P, Wisely, G.B, Ward, P. | | 登録日 | 2021-07-20 | | 公開日 | 2021-08-25 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Overcoming the Pregnane X Receptor Liability: Rational Design to Eliminate PXR-Mediated CYP Induction.
Acs Med.Chem.Lett., 12, 2021
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1HIJ
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7DMW
 | | Crystal structure of CcpC regulatory domain in complex with citrate from Bacillus amyloliquefaciens | | 分子名称: | CITRATE ANION, CcpC | | 著者 | Chen, J, Wang, L, Shang, F, Liu, W, Chen, Y, Lan, J, Bu, T, Bai, X, Xu, Y. | | 登録日 | 2020-12-08 | | 公開日 | 2021-10-27 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Functional and structural analysis of catabolite control protein C that responds to citrate.
Sci Rep, 11, 2021
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7R5A
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1H99
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1HIK
 | | INTERLEUKIN-4 (WILD-TYPE) | | 分子名称: | INTERLEUKIN-4 | | 著者 | Mueller, T, Buehner, M. | | 登録日 | 1995-06-01 | | 公開日 | 1996-01-29 | | 最終更新日 | 2024-06-05 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Human interleukin-4 and variant R88Q: phasing X-ray diffraction data by molecular replacement using X-ray and nuclear magnetic resonance models.
J.Mol.Biol., 247, 1995
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