7QB1

PPARg in complex with inhibitor

This is a non-PDB format compatible entry.

Summary for 7QB1

• Entry DOI: 10.2210/pdb7qb1/pdb
• Descriptor: Peroxisome proliferator-activated receptor gamma, 3-[(3,4-dichlorophenyl)methyl]-4-oxidanylidene-6-phenoxy-phthalazine-1-carboxylic acid, SULFATE ION, ... (4 entities in total)
• Functional Keywords: nuclear hormone receptor cdk9, nuclear protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 66462.30

Authors

Petersen, J. (deposition date: 2021-11-17, release date: 2022-05-04)

• Primary citation: O'Mahony, G.,Petersen, J.,Ek, M.,Rae, R.,Johansson, C.,Jianming, L.,Prokoph, N.,Bergstrom, F.,Bamberg, K.,Giordanetto, F.,Zarrouki, B.,Karlsson, D.,Hogner, A.; Discovery by Virtual Screening of an Inhibitor of CDK5-Mediated PPAR gamma Phosphorylation.; Acs Med.Chem.Lett., 13:681-686, 2022; PubMed: 35450368; DOI: 10.1021/acsmedchemlett.1c00715

Experimental method

X-RAY DIFFRACTION (2.2 Å)