5C25
Crystal Structure of HIV-1 Reverse Transcriptase in Complex with 6-((4-((4-cyanophenyl)amino)-1,3,5-triazin-2-yl)amino)-5,7-dimethyl-2-naphthonitrile (JLJ639), a Non-nucleoside Inhibitor
Summary for 5C25
Entry DOI | 10.2210/pdb5c25/pdb |
Related | 4KKO 4MFB 4O44 4O4G 5C24 |
Descriptor | HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT, HIV-1 REVERSE TRANSCRIPTASE, P51 SUBUNIT, 6-({4-[(4-cyanophenyl)amino]-1,3,5-triazin-2-yl}amino)-5,7- dimethyl-2-naphthonitrile, ... (6 entities in total) |
Functional Keywords | polymerase, reverse transcriptase, hiv, non-nucleoside inhibitor, transferase, hydrolase-dna-inhibitor complex, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) More |
Total number of polymer chains | 2 |
Total formula weight | 114636.58 |
Authors | Chan, A.H.,Frey, K.M.,Anderson, K.S. (deposition date: 2015-06-15, release date: 2015-07-29, Last modification date: 2023-09-27) |
Primary citation | Lee, W.G.,Frey, K.M.,Gallardo-Macias, R.,Spasov, K.A.,Chan, A.H.,Anderson, K.S.,Jorgensen, W.L. Discovery and crystallography of bicyclic arylaminoazines as potent inhibitors of HIV-1 reverse transcriptase. Bioorg.Med.Chem.Lett., 25:4824-4827, 2015 Cited by PubMed: 26166629DOI: 10.1016/j.bmcl.2015.06.074 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.841 Å) |
Structure validation
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