PDB: 42091 件ウェブページステータス検索Chemie searchBIRD

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6Q6T	Crystal structure (orthorombic form) of C36S mutant of thioredoxin h1 from Chlamydomonas reinhardtii 分子名称: DI(HYDROXYETHYL)ETHER, Thioredoxin H-type 著者 Fermani, S, Zaffagnini, M, Lemaire, S.D. 登録日 2018-12-11 公開日 2019-01-16 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (0.94 Å) 主引用文献 Structural and Biochemical Insights into the Reactivity of Thioredoxin h1 fromChlamydomonas reinhardtii. Antioxidants (Basel), 8, 2019
6Q4Z	Structure of an inactive variant (D94N) of MPT-2, a GDP-Man-dependent mannosyltransferase from Leishmania mexicana, in complex with beta-1,2-mannobiose 分子名称: LmxM MPT-2 D94N, beta-D-mannopyranose-(1-2)-alpha-D-mannopyranose 著者 Sobala, L.F, Males, A, Bastidas, L.M, Ward, T, Sernee, M.F, Ralton, J.E, Nero, T.L, Kloehn, J, Viera-Lara, M, Stanton, L, Cobbold, S, Pires, D.E, Hanssen, E, Parker, M.W, Ascher, D.B, Williams, S.J, McConville, M.J, Davies, G.J. 登録日 2018-12-06 公開日 2019-09-25 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites. Cell Host Microbe, 26, 2019
7QNI	CRYSTAL STRUCTURE OF E.coli ALCOHOL DEHYDROGENASE - FucO MUTANT L259V 分子名称: CITRIC ACID, Lactaldehyde reductase 著者 Sridhar, S, Kiema, T.R, Wierenga, R.K, Widersten, M. 登録日 2021-12-20 公開日 2022-10-19 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Structures of lactaldehyde reductase, FucO, link enzyme activity to hydrogen bond networks and conformational dynamics. Febs J., 290, 2023
7QNJ	CRYSTAL STRUCTURE OF E.coli ALCOHOL DEHYDROGENASE - FucO MUTANT F254I COMPLEXED WITH FE, NAD+, AND GLYCEROL 分子名称: FE (III) ION, GLYCEROL, Lactaldehyde reductase, ... 著者 Sridhar, S, Kiema, T.R, Wierenga, R.K, Widersten, M. 登録日 2021-12-20 公開日 2022-10-19 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.66 Å) 主引用文献 Structures of lactaldehyde reductase, FucO, link enzyme activity to hydrogen bond networks and conformational dynamics. Febs J., 290, 2023
4QIR	Crystal structure of Aminopeptidase N in complex with the phosphinic dipeptide analogue LL-(R,S)-2-(pyridin-3-yl)ethylGlyP[CH2]Phe 分子名称: 3-{[(R)-1-amino-3-(pyridin-3-yl)propyl](hydroxy)phosphoryl}-(S)-2-benzylpropanoic acid, Aminopeptidase N, GLYCEROL, ... 著者 Nocek, B, Joachimiak, A, Berlicki, L, Vassiliou, S, Mucha, A. 登録日 2014-06-01 公開日 2014-09-24 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.701 Å) 主引用文献 Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases. J.Med.Chem., 57, 2014
7ZZO	HDAC2 in complex with an inhibitor 分子名称: 2-(cyclohexylazaniumyl)ethanesulfonate, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-25 公開日 2022-09-21 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
4QK2	Structural and Catalytic Effects of Proline Substitution and Surface Loop Deletion in the Extended Active Site of Human Carbonic Anhydrase II - E234P 分子名称: Carbonic anhydrase 2, GLYCEROL, ZINC ION 著者 Boone, C.D, Rasi, V, McKenna, R. 登録日 2014-06-05 公開日 2015-03-04 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.519 Å) 主引用文献 Structural and catalytic effects of proline substitution and surface loop deletion in the extended active site of human carbonic anhydrase II. Febs J., 282, 2015
7MKA	Structure of EC+EC (leading EC-focused) 分子名称: DNA (40-MER), DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB3, ... 著者 Yang, C, Murakami, K. 登録日 2021-04-22 公開日 2022-04-27 最終更新日 2024-10-30 実験手法 ELECTRON MICROSCOPY (3.54 Å) 主引用文献 Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II. Mol.Cell, 82, 2022
8EMQ	Mouse apoferritin heavy chain with zinc determined using single-particle cryo-EM with Apollo camera. 分子名称: FE (III) ION, Ferritin heavy chain, N-terminally processed, ... 著者 Peng, R, Fu, X, Mendez, J.H, Randolph, P.H, Bammes, B, Stagg, S.M. 登録日 2022-09-28 公開日 2022-12-21 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (1.66 Å) 主引用文献 Characterizing the resolution and throughput of the Apollo direct electron detector. J Struct Biol X, 7, 2023
7ZZS	HDAC2 complexed with an inhibitory ligand 分子名称: (5~{S})-5-(4-chlorophenyl)pyrrolidin-2-one, 1,2-ETHANEDIOL, 2-(cyclohexylazaniumyl)ethanesulfonate, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-26 公開日 2022-09-21 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
7ZZT	Ligand binding to HDAC2 分子名称: 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CALCIUM ION, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-26 公開日 2022-09-21 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
4GZY	Crystal structures of bacterial RNA Polymerase paused elongation complexes 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Weixlbaumer, A, Leon, K, Landick, R, Darst, S.A. 登録日 2012-09-06 公開日 2013-02-13 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.5054 Å) 主引用文献 Structural basis of transcriptional pausing in bacteria. Cell(Cambridge,Mass.), 152, 2013
8EN7	Mouse apoferritin heavy chain without zinc determined using single-particle cryo-EM with Apollo camera. 分子名称: FE (III) ION, Ferritin heavy chain, N-terminally processed 著者 Peng, R, Fu, X, Mendez, J.H, Randolph, P.H, Bammes, B, Stagg, S.M. 登録日 2022-09-28 公開日 2022-12-21 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (1.68 Å) 主引用文献 Characterizing the resolution and throughput of the Apollo direct electron detector. J Struct Biol X, 7, 2023
6A1X	Charcot-Leyden crystal protein/Galectin-10 variant W127A 分子名称: Galectin-10 著者 Su, J. 登録日 2018-06-08 公開日 2018-12-26 最終更新日 2024-03-27 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Identification of key amino acid residues determining ligand binding specificity, homodimerization and cellular distribution of human galectin-10 Glycobiology, 29, 2019
7MK9	Complex structure of trailing EC of EC+EC (trailing EC-focused) 分子名称: DNA (40-MER), DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB3, ... 著者 Yang, C, Murakami, K. 登録日 2021-04-22 公開日 2022-04-27 最終更新日 2024-11-13 実験手法 ELECTRON MICROSCOPY (3.54 Å) 主引用文献 Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II. Mol.Cell, 82, 2022
7ZZP	Structure of HDAC2 complexed with an inhibitory ligand 分子名称: (2S)-2-HYDROXYPROPANOIC ACID, 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-25 公開日 2022-09-21 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
7ZZR	HDAC2 in complex with inhibitory ligand 分子名称: 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CALCIUM ION, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-26 公開日 2022-09-21 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (2.168 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
4QAE	Crystal structure of an engineered lipocalin (Anticalin) in complex with human hepcidin 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Hepcidin, ... 著者 Giese, T, Skerra, A. 登録日 2014-05-04 公開日 2015-05-06 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure of a hepcidin-binding anticalin in complex with its peptide ligand To be Published
7ZZW	Ligand binding to HDAC2 分子名称: 1,2-ETHANEDIOL, 2-(cyclohexylazaniumyl)ethanesulfonate, CALCIUM ION, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-26 公開日 2022-09-21 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
6WML	Human TLR8 bound to the potent agonist, GS-9688 (Selgantolimod) 分子名称: (2R)-2-[(2-amino-7-fluoropyrido[3,2-d]pyrimidin-4-yl)amino]-2-methylhexan-1-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor 8, ... 著者 Appleby, T.C, Perry, J.K, Mish, M, Villasenor, A.G, Mackman, R.L. 登録日 2020-04-21 公開日 2021-02-03 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B. J.Med.Chem., 63, 2020
8A0B	Inhibitor binding to HDAC2 分子名称: 1,2-ETHANEDIOL, 1,3-dihydroisoindol-2-yl-[(2R,4S)-4-phenylpyrrolidin-1-ium-2-yl]methanone, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... 著者 Cleasby, A, Tisi, D. 登録日 2022-05-27 公開日 2022-09-21 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.746 Å) 主引用文献 Fragment-Based Discovery of a Novel, Brain Penetrant, Orally Active HDAC2 Inhibitor. Acs Med.Chem.Lett., 13, 2022
6QCT	Influenza B polymerase elongation complex 分子名称: 3 end, 5 end, MAGNESIUM ION, ... 著者 Cusack, S, Kouba, T. 登録日 2018-12-30 公開日 2019-06-05 最終更新日 2025-07-02 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Structural snapshots of actively transcribing influenza polymerase. Nat.Struct.Mol.Biol., 26, 2019
7MHS	Structure of p97 (subunits A to E) with substrate engaged 分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... 著者 Xu, Y, Han, H, Cooney, I, Hill, C.P, Shen, P.S. 登録日 2021-04-15 公開日 2022-05-11 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Active conformation of the p97-p47 unfoldase complex. Nat Commun, 13, 2022
4Q9Y	Crystal structure of 3-methylthiophenol bound to human carbonic anhydrase II 分子名称: 3-methylbenzenethiol, Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ... 著者 Martin, D.P, Cohen, S.M. 登録日 2014-05-02 公開日 2015-03-11 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Exploring the influence of the protein environment on metal-binding pharmacophores. J.Med.Chem., 57, 2014
6WRK	Crystal structure of 3rd-generation Mj 3-nitro-tyrosine tRNA synthetase ("A7") bound to 3-nitro-tyrosine 分子名称: GLYCEROL, META-NITRO-TYROSINE, SODIUM ION, ... 著者 Beyer, J.N, Hosseinzadeh, P, Karplus, P.A, Mehl, R.A, Cooley, R.B. 登録日 2020-04-29 公開日 2020-07-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Overcoming Near-Cognate Suppression in a Release Factor 1-Deficient Host with an Improved Nitro-Tyrosine tRNA Synthetase. J.Mol.Biol., 432, 2020

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