5NX9
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![BU of 5nx9 by Molmil](/molmil-images/mine/5nx9) | Crystal structure of Neanderthal Adenylosuccinate Lyase (ADSL) in complex with its products AMP and fumarate | 分子名称: | 2-[9-(3,4-DIHYDROXY-5-PHOSPHONOOXYMETHYL-TETRAHYDRO-FURAN-2-YL)-9H-PURIN-6-YLAMINO]-SUCCINIC ACID, ADENOSINE MONOPHOSPHATE, Adenylosuccinate lyase, ... | 著者 | Van Laer, B, Kapp, U, Soler-Lopez, M, Leonard, G, Mueller-Dieckmann, C. | 登録日 | 2017-05-09 | 公開日 | 2018-05-30 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Molecular comparison of Neanderthal and Modern Human adenylosuccinate lyase. Sci Rep, 8, 2018
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5O3L
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![BU of 5o3l by Molmil](/molmil-images/mine/5o3l) | Paired helical filament in Alzheimer's disease brain | 分子名称: | Microtubule-associated protein tau | 著者 | Fitzpatrick, A.W.P, Falcon, B, He, S, Murzin, A.G, Murshudov, G, Garringer, H.G, Crowther, R.A, Ghetti, B, Goedert, M, Scheres, S.H.W. | 登録日 | 2017-05-24 | 公開日 | 2017-07-26 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structures of tau filaments from Alzheimer's disease. Nature, 547, 2017
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5NXA
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![BU of 5nxa by Molmil](/molmil-images/mine/5nxa) | Crystal structure of Neanderthal Adenylosuccinate Lyase (ADSL)in complex with its products AICAR and fumarate | 分子名称: | AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, Adenylosuccinate lyase, CHLORIDE ION, ... | 著者 | Van Laer, B, Kapp, U, Soler-Lopez, M, Leonard, G, Mueller-Dieckmann, C. | 登録日 | 2017-05-09 | 公開日 | 2018-05-30 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Molecular comparison of Neanderthal and Modern Human adenylosuccinate lyase. Sci Rep, 8, 2018
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5NX8
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![BU of 5nx8 by Molmil](/molmil-images/mine/5nx8) | Crystal structure of Neanderthal Adenylosuccinate Lyase (ADSL) | 分子名称: | Adenylosuccinate lyase, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Van Laer, B, Kapp, U, Soler-Lopez, M, Leonard, G, Mueller-Dieckmann, C. | 登録日 | 2017-05-09 | 公開日 | 2018-05-30 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Molecular comparison of Neanderthal and Modern Human adenylosuccinate lyase. Sci Rep, 8, 2018
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7RTG
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![BU of 7rtg by Molmil](/molmil-images/mine/7rtg) | Crystal Structure of the Human Adenosine Deaminase 1 | 分子名称: | Adenosine deaminase, ZINC ION | 著者 | Ma, M.T, Lieberman, R.L, Blazeck, J, Jennings, M.R. | 登録日 | 2021-08-13 | 公開日 | 2022-01-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.591 Å) | 主引用文献 | Catalytically active holo Homo sapiens adenosine deaminase I adopts a closed conformation. Acta Crystallogr D Struct Biol, 78, 2022
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6A0X
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![BU of 6a0x by Molmil](/molmil-images/mine/6a0x) | |
4XEA
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![BU of 4xea by Molmil](/molmil-images/mine/4xea) | Crystal structure of putative M16-like peptidase from Alicyclobacillus acidocaldarius | 分子名称: | ACETATE ION, GLYCEROL, NICKEL (II) ION, ... | 著者 | Michalska, K, Tesar, C, Bearden, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2014-12-23 | 公開日 | 2015-03-18 | 最終更新日 | 2019-12-25 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal structure of putative M16-like peptidase from Alicyclobacillus acidocaldarius To Be Published
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7SHX
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![BU of 7shx by Molmil](/molmil-images/mine/7shx) | |
7SJU
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![BU of 7sju by Molmil](/molmil-images/mine/7sju) | Myocilin OLF mutant T293K | 分子名称: | CALCIUM ION, GLYCEROL, Myocilin, ... | 著者 | Scelsi, H.S, Barlow, B.M, Lieberman, R.L. | 登録日 | 2021-10-19 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.391 Å) | 主引用文献 | Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
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7SIJ
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![BU of 7sij by Molmil](/molmil-images/mine/7sij) | Myocilin OLF mutant E352K | 分子名称: | CALCIUM ION, GLYCEROL, Myocilin, ... | 著者 | Scelsi, H.S, Barlow, B.M, Lieberman, R.L. | 登録日 | 2021-10-14 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
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7SJV
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![BU of 7sjv by Molmil](/molmil-images/mine/7sjv) | Myocilin OLF mutant T353I | 分子名称: | CALCIUM ION, Myocilin, C-terminal fragment, ... | 著者 | Scelsi, H.S, Barlow, B.M, Lieberman, R.L. | 登録日 | 2021-10-19 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | 主引用文献 | Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
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7SKF
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![BU of 7skf by Molmil](/molmil-images/mine/7skf) | Myocilin OLF mutant A445V | 分子名称: | CALCIUM ION, GLYCEROL, Myocilin, ... | 著者 | Scelsi, H.S, Barlow, B.M, Lieberman, R.L. | 登録日 | 2021-10-20 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.282 Å) | 主引用文献 | Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
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7SKE
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![BU of 7ske by Molmil](/molmil-images/mine/7ske) | Myocilin OLF mutant R296H | 分子名称: | CALCIUM ION, GLYCEROL, Myocilin, ... | 著者 | Scelsi, H.S, Barlow, B.M, Lieberman, R.L. | 登録日 | 2021-10-20 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | 主引用文献 | Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
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7SJT
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![BU of 7sjt by Molmil](/molmil-images/mine/7sjt) | Myocilin OLF mutant K398R | 分子名称: | CALCIUM ION, Myocilin, C-terminal fragment, ... | 著者 | Scelsi, H.S, Barlow, B.M, Lieberman, R.L. | 登録日 | 2021-10-19 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
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7SJW
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![BU of 7sjw by Molmil](/molmil-images/mine/7sjw) | Myocilin OLF mutant L303I | 分子名称: | CALCIUM ION, GLYCEROL, Myocilin, ... | 著者 | Scelsi, H.S, Barlow, B.M, Lieberman, R.L. | 登録日 | 2021-10-19 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
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7SKG
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![BU of 7skg by Molmil](/molmil-images/mine/7skg) | Myocilin OLF mutant V329M | 分子名称: | CALCIUM ION, GLYCEROL, Myocilin, ... | 著者 | Scelsi, H.S, Barlow, B.M, Lieberman, R.L. | 登録日 | 2021-10-20 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | 主引用文献 | Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
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7SIB
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![BU of 7sib by Molmil](/molmil-images/mine/7sib) | Myocilin OLF mutant K500R | 分子名称: | CALCIUM ION, GLYCEROL, Myocilin, ... | 著者 | Scelsi, H.S, Barlow, B.M, Lieberman, R.L. | 登録日 | 2021-10-13 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
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7SKD
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![BU of 7skd by Molmil](/molmil-images/mine/7skd) | Myocilin OLF mutant S331L | 分子名称: | CALCIUM ION, Myocilin, C-terminal fragment, ... | 著者 | Scelsi, H.S, Barlow, B.M, Lieberman, R.L. | 登録日 | 2021-10-20 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.712 Å) | 主引用文献 | Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
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7SP1
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![BU of 7sp1 by Molmil](/molmil-images/mine/7sp1) | RNA-induced tau amyloid fibril | 分子名称: | Isoform Tau-F of Microtubule-associated protein tau, RNA (5'-R(*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') | 著者 | Abskharon, R, Sawaya, M.R, Boyer, D.R, Eisenberg, D.S. | 登録日 | 2021-11-02 | 公開日 | 2022-03-30 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation. Proc.Natl.Acad.Sci.USA, 119, 2022
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6AZP
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![BU of 6azp by Molmil](/molmil-images/mine/6azp) | |
2BKS
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![BU of 2bks by Molmil](/molmil-images/mine/2bks) | crystal structure of Renin-PF00074777 complex | 分子名称: | (6R)-6-({[1-(3-HYDROXYPROPYL)-1,7-DIHYDROQUINOLIN-7-YL]OXY}METHYL)-1-(4-{3-[(2-METHOXYBENZYL)OXY]PROPOXY}PHENYL)PIPERAZIN-2-ONE, Renin | 著者 | Powell, N.A, Clay, E.H, Holsworth, D.D, Edmunds, J.J, Bryant, J.W, Ryan, J.M, Jalaie, M, Zhang, E. | 登録日 | 2005-02-18 | 公開日 | 2006-04-05 | 最終更新日 | 2021-07-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Equipotent Activity in Both Enantiomers of a Series of Ketopiperazine-Based Renin Inhibitors Bioorg.Med.Chem.Lett., 15, 2005
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4YO1
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![BU of 4yo1 by Molmil](/molmil-images/mine/4yo1) | |
7T8D
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![BU of 7t8d by Molmil](/molmil-images/mine/7t8d) | Myocilin OLF mutant V449I | 分子名称: | CALCIUM ION, GLYCEROL, Myocilin, ... | 著者 | Scelsi, H.S, Barlow, B.M, Lieberman, R.L. | 登録日 | 2021-12-16 | 公開日 | 2023-01-11 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Quantitative differentiation of benign and misfolded glaucoma-causing myocilin variants on the basis of protein thermal stability. Dis Model Mech, 16, 2023
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5JD5
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![BU of 5jd5 by Molmil](/molmil-images/mine/5jd5) | Crystal structure of MGS-MilE3, an alpha/beta hydrolase enzyme from the metagenome of pyrene-phenanthrene enrichment culture with sediment sample of Milazzo Harbor, Italy | 分子名称: | CHLORIDE ION, MGS-MilE3 | 著者 | Stogios, P.J, Xu, X, Cui, H, Martinez-Martinez, M, Chernikova, T.N, Golyshin, P.N, Yakimov, M.M, Ferrer, M, Savchenko, A. | 登録日 | 2016-04-15 | 公開日 | 2016-05-04 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal structure of MGS-MilE3, an alpha/beta hydrolase enzyme from the metagenome of pyrene-phenanthrene enrichment culture with sediment sample of Milazzo Harbor, Italy To Be Published
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4WY3
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![BU of 4wy3 by Molmil](/molmil-images/mine/4wy3) | Structure of SARS-3CL protease complex with a phenylbenzoyl (R,S)-N-decalin type inhibitor | 分子名称: | (2S)-2-({[(3R,4aS,8aR)-2-(biphenyl-4-ylcarbonyl)decahydroisoquinolin-3-yl]methyl}amino)-3-(1H-imidazol-5-yl)propanal, 3C-like proteinase | 著者 | Akaji, K, Teruya, K, Shimamoto, Y, Sanjho, A, Yamashita, E, Nakagawa, A. | 登録日 | 2014-11-15 | 公開日 | 2015-02-18 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Fused-ring structure of decahydroisoquinolin as a novel scaffold for SARS 3CL protease inhibitors. Bioorg.Med.Chem., 23, 2015
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