5NXA

Crystal structure of Neanderthal Adenylosuccinate Lyase (ADSL)in complex with its products AICAR and fumarate

Summary for 5NXA

• Entry DOI: 10.2210/pdb5nxa/pdb
• Descriptor: Adenylosuccinate lyase, N-{[5-AMINO-1-(5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-1H-IMIDAZOL-4-YL]CARBONYL}-L-ASPARTIC ACID, CHLORIDE ION, ... (6 entities in total)
• Functional Keywords: adenylosuccinate lyase, fumarase, lyase
• Biological source: Homo sapiens neanderthalensis
• Total number of polymer chains: 8
• Total formula weight: 445649.45

Authors

Van Laer, B.,Kapp, U.,Soler-Lopez, M.,Leonard, G.,Mueller-Dieckmann, C. (deposition date: 2017-05-09, release date: 2018-05-30, Last modification date: 2024-01-17)

• Primary citation: Van Laer, B.,Kapp, U.,Soler-Lopez, M.,Moczulska, K.,Paabo, S.,Leonard, G.,Mueller-Dieckmann, C.; Molecular comparison of Neanderthal and Modern Human adenylosuccinate lyase.; Sci Rep, 8:18008-18008, 2018; PubMed: 30573755; DOI: 10.1038/s41598-018-36195-5

Experimental method

X-RAY DIFFRACTION (2.4 Å)