5NXA
Crystal structure of Neanderthal Adenylosuccinate Lyase (ADSL)in complex with its products AICAR and fumarate
Summary for 5NXA
Entry DOI | 10.2210/pdb5nxa/pdb |
Descriptor | Adenylosuccinate lyase, N-{[5-AMINO-1-(5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)-1H-IMIDAZOL-4-YL]CARBONYL}-L-ASPARTIC ACID, CHLORIDE ION, ... (6 entities in total) |
Functional Keywords | adenylosuccinate lyase, fumarase, lyase |
Biological source | Homo sapiens neanderthalensis |
Total number of polymer chains | 8 |
Total formula weight | 445649.45 |
Authors | Van Laer, B.,Kapp, U.,Soler-Lopez, M.,Leonard, G.,Mueller-Dieckmann, C. (deposition date: 2017-05-09, release date: 2018-05-30, Last modification date: 2024-01-17) |
Primary citation | Van Laer, B.,Kapp, U.,Soler-Lopez, M.,Moczulska, K.,Paabo, S.,Leonard, G.,Mueller-Dieckmann, C. Molecular comparison of Neanderthal and Modern Human adenylosuccinate lyase. Sci Rep, 8:18008-18008, 2018 Cited by PubMed: 30573755DOI: 10.1038/s41598-018-36195-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
Download full validation report