5LEL
 
 | | Crystal structure of DARPin-DARPin rigid fusion, variant DD_Off7_10_3G124 in complex with Maltose-binding Protein and Green Fluorescent Protein | | 分子名称: | DD_Off7_10_3G124, Green fluorescent protein, Maltose-binding periplasmic protein | | 著者 | Batyuk, A, Wu, Y, Mittl, P.R, Plueckthun, A. | | 登録日 | 2016-06-30 | | 公開日 | 2017-11-15 | | 最終更新日 | 2019-10-16 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Rigidly connected multispecific artificial binders with adjustable geometries.
Sci Rep, 7, 2017
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5LG9
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2COE
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3GJP
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5LFZ
 | | T48 deacetylase | | 分子名称: | ArCE4A, NICKEL (II) ION | | 著者 | Rothweiler, U. | | 登録日 | 2016-07-05 | | 公開日 | 2017-08-02 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.561 Å) | | 主引用文献 | Structure and function of a CE4 deacetylase isolated from a marine environment.
PLoS ONE, 12, 2017
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6LP2
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5LGC
 | | T48 deacetylase with substrate | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ArCE4A | | 著者 | Rothweiler, U. | | 登録日 | 2016-07-06 | | 公開日 | 2017-08-02 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Structure and function of a CE4 deacetylase isolated from a marine environment.
PLoS ONE, 12, 2017
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2YRP
 | | Solution structure of the TIG domain from Human Nuclear factor of activated T-cells, cytoplasmic 4 | | 分子名称: | Nuclear factor of activated T-cells, cytoplasmic 4 | | 著者 | Tomizawa, T, Koshiba, S, Watanabe, S, Harada, T, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2007-04-02 | | 公開日 | 2008-02-12 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the TIG domain from Human Nuclear factor of activated T-cells, cytoplasmic 4
To be Published
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5M15
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1RB6
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5M13
 | | Synthetic nanobody in complex with MBP | | 分子名称: | 1,2-ETHANEDIOL, Maltose-binding periplasmic protein, synthetic Nanobody L2_C06 (a-MBP#2) | | 著者 | Zimmermann, I, Egloff, P, Seeger, M.A. | | 登録日 | 2016-10-07 | | 公開日 | 2017-11-15 | | 最終更新日 | 2019-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.372 Å) | | 主引用文献 | Synthetic single domain antibodies for the conformational trapping of membrane proteins.
Elife, 7, 2018
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4XJ0
 | | Crystal structure of ERK2 in complex with an inhibitor 14K | | 分子名称: | 1-[(1S)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-4-yl]pyridin-2(1H)-one, Mitogen-activated protein kinase 1 | | 著者 | Yin, J, Wang, W. | | 登録日 | 2015-01-08 | | 公開日 | 2015-09-16 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | | 主引用文献 | Discovery of highly potent, selective, and efficacious small molecule inhibitors of ERK1/2.
J.Med.Chem., 58, 2015
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5U0A
 | | CRISPR RNA-guided surveillance complex | | 分子名称: | CRISPR-associated protein, Cas5e family, Cse1 family, ... | | 著者 | Xiao, Y, Luo, M, Hayes, R.P, Kim, J, Ng, S, Ding, F, Liao, M, Ke, A. | | 登録日 | 2016-11-23 | | 公開日 | 2017-08-09 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System.
Cell, 170, 2017
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5U07
 | | CRISPR RNA-guided surveillance complex | | 分子名称: | CRISPR-associated protein, Cas5e family, Cse1 family, ... | | 著者 | Xiao, Y, Luo, M, Hayes, R.P, Kim, J, Ng, S, Ding, F, Liao, M, Ke, A. | | 登録日 | 2016-11-23 | | 公開日 | 2017-08-09 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System.
Cell, 170, 2017
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5LS0
 | | Crystal structure of Inorganic Pyrophosphatase PPA1 from Arabidopsis thaliana | | 分子名称: | DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, Soluble inorganic pyrophosphatase 1 | | 著者 | Grzechowiak, M, Sikorski, M, Jaskolski, M. | | 登録日 | 2016-08-22 | | 公開日 | 2017-09-13 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Crystal structures of plant inorganic pyrophosphatase, an enzyme with a moonlighting autoproteolytic activity.
Biochem.J., 476, 2019
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5LU1
 | | Human 14-3-3 sigma CLU3 mutant complexed with short HSPB6 phosphopeptide | | 分子名称: | 14-3-3 protein sigma, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Heat shock protein beta-6 | | 著者 | Sluchanko, N.N, Beelen, S, Kulikova, A.A, Weeks, S.D, Antson, A.A, Gusev, N.B, Strelkov, S.V. | | 登録日 | 2016-09-07 | | 公開日 | 2017-02-01 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural Basis for the Interaction of a Human Small Heat Shock Protein with the 14-3-3 Universal Signaling Regulator.
Structure, 25, 2017
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2C9C
 | | Structural basis of the nucleotide driven conformational changes in the AAA domain of transcription activator PspF | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PSP OPERON TRANSCRIPTIONAL ACTIVATOR | | 著者 | Rappas, M, Schumacher, J, Niwa, H, Buck, M, Zhang, X. | | 登録日 | 2005-12-09 | | 公開日 | 2006-02-01 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural Basis of the Nucleotide Driven Conformational Changes in the Aaa(+) Domain of Transcription Activator Pspf.
J.Mol.Biol., 357, 2006
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2C98
 | | Structural basis of the nucleotide driven conformational changes in the AAA domain of transcription activator PspF | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, PSP OPERON TRANSCRIPTIONAL ACTIVATOR | | 著者 | Rappas, M, Schumacher, J, Niwa, H, Buck, M, Zhang, X. | | 登録日 | 2005-12-09 | | 公開日 | 2006-02-01 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural Basis of the Nucleotide Driven Conformational Changes in the Aaa(+) Domain of Transcription Activator Pspf.
J.Mol.Biol., 357, 2006
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2C99
 | | Structural basis of the nucleotide driven conformational changes in the AAA domain of transcription activator PspF | | 分子名称: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PSP OPERON TRANSCRIPTIONAL ACTIVATOR | | 著者 | Rappas, M, Schumacher, J, Niwa, H, Buck, M, Zhang, X. | | 登録日 | 2005-12-09 | | 公開日 | 2006-02-01 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural Basis of the Nucleotide Driven Conformational Changes in the Aaa(+) Domain of Transcription Activator Pspf.
J.Mol.Biol., 357, 2006
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2C96
 | | Structural basis of the nucleotide driven conformational changes in the AAA domain of transcription activator PspF | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, PSP OPERON TRANSCRIPTIONAL ACTIVATOR | | 著者 | Rappas, M, Schumacher, J, Niwa, H, Buck, M, Zhang, X. | | 登録日 | 2005-12-09 | | 公開日 | 2006-02-01 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural Basis of the Nucleotide Driven Conformational Changes in the Aaa(+) Domain of Transcription Activator Pspf.
J.Mol.Biol., 357, 2006
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2ZE2
 | | Crystal structure of L100I/K103N mutant HIV-1 reverse transcriptase (RT) in complex with TMC278 (rilpivirine), a non-nucleoside RT inhibitor | | 分子名称: | 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, Reverse transcriptase/ribonuclease H, p51 RT | | 著者 | Das, K, Bauman, J.D, Clark Jr, A.D, Shatkin, A.J, Arnold, E. | | 登録日 | 2007-12-05 | | 公開日 | 2008-02-12 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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4ICL
 | | HIV-1 reverse transcriptase with bound fragment at the incoming dNTP binding site | | 分子名称: | 4-(4-methylpiperazin-1-yl)benzoic acid, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, DIMETHYL SULFOXIDE, ... | | 著者 | Bauman, J.D, Patel, D, Arnold, E. | | 登録日 | 2012-12-10 | | 公開日 | 2013-02-06 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-ray Crystallographic Fragment Screening.
J.Med.Chem., 56, 2013
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4IG0
 | | HIV-1 reverse transcriptase with bound fragment at the 507 site | | 分子名称: | 2-({[2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoethyl](methyl)amino}methyl)quinazolin-4(1H)-one, DIMETHYL SULFOXIDE, P51 RT, ... | | 著者 | Bauman, J.D, Patel, D, Arnold, E. | | 登録日 | 2012-12-15 | | 公開日 | 2013-02-06 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-ray Crystallographic Fragment Screening.
J.Med.Chem., 56, 2013
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4IG3
 | | HIV-1 reverse transcriptase with bound fragment near Knuckles site | | 分子名称: | (5S)-6,6-dimethyl-5-[(6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl]-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-6-ium, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, DIMETHYL SULFOXIDE, ... | | 著者 | Bauman, J.D, Patel, D, Arnold, E. | | 登録日 | 2012-12-15 | | 公開日 | 2013-02-06 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-ray Crystallographic Fragment Screening.
J.Med.Chem., 56, 2013
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4IFY
 | | HIV-1 reverse transcriptase with bound fragment at the Knuckles site | | 分子名称: | 1-[4-(trifluoromethoxy)phenyl]methanamine, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, DIMETHYL SULFOXIDE, ... | | 著者 | Bauman, J.D, Patel, D, Arnold, E. | | 登録日 | 2012-12-15 | | 公開日 | 2013-02-06 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-ray Crystallographic Fragment Screening.
J.Med.Chem., 56, 2013
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