6PQ8
 
 | | Crystal structure of TLA-1 S70G extended spectrum Beta-lactamase in complex with clavulanic acid | | 分子名称: | (2R,3Z,5R)-3-(2-HYDROXYETHYLIDENE)-7-OXO-4-OXA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID, ACETATE ION, ASPARTIC ACID, ... | | 著者 | Rudino-Pinera, E, Cifuentes-Castro, V.H, Rodriguez-Almazan, C. | | 登録日 | 2019-07-08 | | 公開日 | 2019-12-11 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The crystal structure of ESBL TLA-1 in complex with clavulanic acid reveals a second acylation site.
Biochem.Biophys.Res.Commun., 522, 2020
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5EN2
 | | Molecular basis for antibody-mediated neutralization of New World hemorrhagic fever mammarenaviruses | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | 著者 | Mahmutovic, S, Clark, L, Levis, S, Briggiler, A, Enria, D, Harrison, S.C, Abraham, J. | | 登録日 | 2015-11-09 | | 公開日 | 2015-12-30 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.821 Å) | | 主引用文献 | Molecular Basis for Antibody-Mediated Neutralization of New World Hemorrhagic Fever Mammarenaviruses.
Cell Host Microbe, 18, 2015
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7U99
 | | EGFR kinase in complex with a macrocyclic inhibitor | | 分子名称: | 19-chloro-22-methoxy-8,9,11,12,14,15-hexahydro-21H-4,6-ethenopyrimido[5,4-m][1,4,7,10,15]benzotetraoxazacycloheptadecine, CITRATE ANION, Epidermal growth factor receptor | | 著者 | Beyett, T.S, Eck, M.J. | | 登録日 | 2022-03-10 | | 公開日 | 2022-11-23 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
J.Med.Chem., 65, 2022
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7U98
 | | EGFR(T790M/V948R) in complex with a macrocyclic inhibitor | | 分子名称: | 19-chloro-18-fluoro-22-methoxy-8,9,11,12,14,15-hexahydro-21H-4,6-ethenopyrimido[5,4-m][1,4,7,10,15]benzotetraoxazacycloheptadecine, Epidermal growth factor receptor | | 著者 | Beyett, T.S, Eck, M.J. | | 登録日 | 2022-03-10 | | 公開日 | 2022-11-23 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.42 Å) | | 主引用文献 | Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
J.Med.Chem., 65, 2022
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6JPN
 | | Crystal structure of the catalytic domain of a multi-domain alginate lyase Dp0100 from thermophilic bacterium Defluviitalea phaphyphila | | 分子名称: | Alginate lyase, CALCIUM ION, MAGNESIUM ION, ... | | 著者 | Ji, S.Q, Dix, S.R, Aziz, A, Sedelnikova, S.E, Li, F.L, Rice, D.W. | | 登録日 | 2019-03-27 | | 公開日 | 2019-10-30 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | The molecular basis of endolytic activity of a multidomain alginate lyase fromDefluviitalea phaphyphila, a representative of a new lyase family, PL39.
J.Biol.Chem., 294, 2019
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7U9A
 | | EGFR in complex with a macrocyclic inhibitor | | 分子名称: | 4-(5-chloro-4-fluoro-2-hydroxyanilino)-7-methoxyquinazolin-6-ol, CITRATE ANION, Epidermal growth factor receptor | | 著者 | Beyett, T.S, Eck, M.J. | | 登録日 | 2022-03-10 | | 公開日 | 2022-11-23 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19.
J.Med.Chem., 65, 2022
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6NIN
 | | Rhodobacter sphaeroides bc1 with STIGMATELLIN A | | 分子名称: | 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, Cytochrome b, Cytochrome c1, ... | | 著者 | Xia, D, Zhou, F, Esser, L. | | 登録日 | 2018-12-31 | | 公開日 | 2019-06-19 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Crystal structure of bacterial cytochromebc1in complex with azoxystrobin reveals a conformational switch of the Rieske iron-sulfur protein subunit.
J.Biol.Chem., 294, 2019
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6PSC
 | | Antibody scFv-M204 trimeric state | | 分子名称: | scFv-M204 antibody | | 著者 | Abskharon, R, Sawaya, M.R, Seidler, P.M, Cascio, D, Eisenberg, D.S. | | 登録日 | 2019-07-12 | | 公開日 | 2020-06-17 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | | 主引用文献 | Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease.
J.Biol.Chem., 295, 2020
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6Q36
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7QPB
 | | Catalytic C-lobe of the HECT-type ubiquitin ligase E6AP in complex with a hybrid foldamer-peptide macrocycle | | 分子名称: | Isoform I of Ubiquitin-protein ligase E3A, hybrid foldamer-peptide macrocycle | | 著者 | Dengler, S, Howard, R.T, Morozov, V, Tsiamantas, C, Douat, C, Suga, H, Huc, I. | | 登録日 | 2022-01-03 | | 公開日 | 2023-09-27 | | 最終更新日 | 2024-07-10 | | 実験手法 | X-RAY DIFFRACTION (2.342 Å) | | 主引用文献 | Display Selection of a Hybrid Foldamer-Peptide Macrocycle.
Angew.Chem.Int.Ed.Engl., 62, 2023
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6PYV
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3O9V
 | | Crystal Structure of Human DPP4 Bound to TAK-986 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(aminomethyl)-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridine-3-carboxic acid, ... | | 著者 | Yano, J.K, Aertgeerts, K. | | 登録日 | 2010-08-04 | | 公開日 | 2011-02-09 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Discovery of a 3-Pyridylacetic Acid Derivative (TAK-100) as a Potent, Selective and Orally Active Dipeptidyl Peptidase IV (DPP-4) Inhibitor.
J.Med.Chem., 53, 2011
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6PV5
 | | Structure of CpGH84B | | 分子名称: | 1,2-ETHANEDIOL, Putative O-GlcNAcase nagJ | | 著者 | Pluvinage, B, Boraston, A.B. | | 登録日 | 2019-07-19 | | 公開日 | 2019-09-11 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Structural and functional analysis of four family 84 glycoside hydrolases from the opportunistic pathogen Clostridium perfringens.
Glycobiology, 30, 2019
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8GM4
 | | Functional construct of the Eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor | | 分子名称: | 7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... | | 著者 | Piserchio, A, Isiorho, E.A, Dalby, K.N, Ghose, R. | | 登録日 | 2023-03-24 | | 公開日 | 2023-05-31 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | Structure of the complex between calmodulin and a functional construct of eukaryotic elongation factor 2 kinase bound to an ATP-competitive inhibitor.
J.Biol.Chem., 299, 2023
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6PSG
 | | Crystal Structure of Class D Beta-lactamase OXA-48 with Faropenem | | 分子名称: | (2R,5R)-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-5-[(2R)-tetrahydrofuran-2-yl]-2,5-dihydro-1,3-thiazole-4-carboxylic acid, CHLORIDE ION, Class D Carbapenemase OXA-48, ... | | 著者 | Akhtar, A, Chen, Y. | | 登録日 | 2019-07-12 | | 公開日 | 2020-01-22 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | | 主引用文献 | Structural Basis for Substrate Specificity and Carbapenemase Activity of OXA-48 Class D beta-Lactamase.
Acs Infect Dis., 6, 2020
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6PTR
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6PYJ
 | | Crystal Structure of HLA-B*2705 in complex with LRN, a self-peptide | | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, B-27 alpha chain, ... | | 著者 | Gras, S. | | 登録日 | 2019-07-30 | | 公開日 | 2019-12-04 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | | 主引用文献 | Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation.
J.Biol.Chem., 294, 2019
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6NFE
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6PTU
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1O8A
 | | Crystal Structure of Human Angiotensin Converting Enzyme (Native). | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ANGIOTENSIN CONVERTING ENZYME, ... | | 著者 | Natesh, R, Schwager, S.L.U, Sturrock, E.D, Acharya, K.R. | | 登録日 | 2002-11-26 | | 公開日 | 2003-02-07 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of the human angiotensin-converting enzyme-lisinopril complex.
Nature, 421, 2003
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6Q85
 | | Structure of Fucosylated D-antimicrobial peptide SB11 in complex with the Fucose-binding lectin PA-IIL at 1.990 Angstrom resolution | | 分子名称: | 3,7-anhydro-2,8-dideoxy-L-glycero-D-gluco-octonic acid, AMINO GROUP, CALCIUM ION, ... | | 著者 | Baeriswyl, S, Stocker, A, Reymond, J.-L. | | 登録日 | 2018-12-14 | | 公開日 | 2019-03-20 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | X-ray Crystal Structures of Short Antimicrobial Peptides as Pseudomonas aeruginosa Lectin B Complexes.
Acs Chem.Biol., 14, 2019
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6PWI
 | | Structure of CpGH84D | | 分子名称: | 1,2-ETHANEDIOL, Putative hyaluronoglucosaminidase | | 著者 | Pluvinage, B, Boraston, A.B. | | 登録日 | 2019-07-23 | | 公開日 | 2019-09-11 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Structural and functional analysis of four family 84 glycoside hydrolases from the opportunistic pathogen Clostridium perfringens.
Glycobiology, 30, 2019
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7Q34
 | | Crystal structure of the multidrug binding transcriptional regulator LmrR in complex squaraine dye | | 分子名称: | 2,4-bis[(E)-(1-ethyl-3,3-dimethyl-indol-2-ylidene)methyl]cyclobutane-1,3-dione, Helix-turn-helix transcriptional regulator, NICKEL (II) ION | | 著者 | Liutkus, M, Mejias, S.H, Barolo, C, Cortajarena, A.L. | | 登録日 | 2021-10-26 | | 公開日 | 2022-06-01 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Designing Artificial Fluorescent Proteins: Squaraine-LmrR Biophosphors for High Performance Deep-Red Biohybrid Light-Emitting Diodes
Adv Funct Mater, 32, 2022
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5FA2
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6QE2
 | | Crystal structure of Paleococcus ferrophilus monoacylglycerol lipase. | | 分子名称: | GLYCEROL, LAURYL DIMETHYLAMINE-N-OXIDE, Monoacylglycerol lipase | | 著者 | Labar, G, Demarez, M, Brandt, N, Wouters, J, Leherte, F. | | 登録日 | 2019-01-04 | | 公開日 | 2020-02-05 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.7461 Å) | | 主引用文献 | Structure and Dynamics of an Archeal Monoglyceride Lipase from Palaeococcus ferrophilus as Revealed by Crystallography and In Silico Analysis.
Biomolecules, 11, 2021
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