7U98

EGFR(T790M/V948R) in complex with a macrocyclic inhibitor

Summary for 7U98

Entry DOI	10.2210/pdb7u98/pdb
Descriptor	Epidermal growth factor receptor, 19-chloro-18-fluoro-22-methoxy-8,9,11,12,14,15-hexahydro-21H-4,6-ethenopyrimido[5,4-m][1,4,7,10,15]benzotetraoxazacycloheptadecine (2 entities in total)
Functional Keywords	egfr, kinase, macrocycle, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	152697.83
Authors	Beyett, T.S.,Eck, M.J. (deposition date: 2022-03-10, release date: 2022-11-23, Last modification date: 2023-10-25)
Primary citation	Amrhein, J.A.,Beyett, T.S.,Feng, W.W.,Kramer, A.,Weckesser, J.,Schaeffner, I.K.,Rana, J.K.,Janne, P.A.,Eck, M.J.,Knapp, S.,Hanke, T. Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19. J.Med.Chem., 65:15679-15697, 2022 Cited by PubMed: 36384036 DOI: 10.1021/acs.jmedchem.2c01041 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.42 Å)

Structure validation