6PQ8

Crystal structure of TLA-1 S70G extended spectrum Beta-lactamase in complex with clavulanic acid

Summary for 6PQ8

Entry DOI	10.2210/pdb6pq8/pdb
Descriptor	Beta-lactamase, ASPARTIC ACID, (2R,3Z,5R)-3-(2-HYDROXYETHYLIDENE)-7-OXO-4-OXA-1-AZABICYCLO[3.2.0]HEPTANE-2-CARBOXYLIC ACID, ... (8 entities in total)
Functional Keywords	lactamase, antibiotic, resistance, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	34750.79
Authors	Rudino-Pinera, E.,Cifuentes-Castro, V.H.,Rodriguez-Almazan, C. (deposition date: 2019-07-08, release date: 2019-12-11, Last modification date: 2023-10-11)
Primary citation	Cifuentes-Castro, V.,Rodriguez-Almazan, C.,Silva-Sanchez, J.,Rudino-Pinera, E. The crystal structure of ESBL TLA-1 in complex with clavulanic acid reveals a second acylation site. Biochem.Biophys.Res.Commun., 522:545-551, 2020 Cited by PubMed: 31780261 DOI: 10.1016/j.bbrc.2019.11.138 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation