6QL1
 
 | Crystal structure of chimeric carbonic anhydrase VI with 4-[(4,6-dimethylpyrimidin-2-yl)thio]-2,3,5,6-tetrafluorobenzenesulfonamide | 分子名称: | 1,2-ETHANEDIOL, 4-[(4,6-dimethylpyrimidin-2-yl)thio]-2,3,5,6-tetrafluorobenzenesulfonamide, BICINE, ... | 著者 | Smirnov, A, Manakova, E, Grazulis, S. | 登録日 | 2019-01-31 | 公開日 | 2019-09-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Engineered Carbonic Anhydrase VI-Mimic Enzyme Switched the Structure and Affinities of Inhibitors. Sci Rep, 9, 2019
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7E6F
 
 | Crystal structure of PMP-bound form of cysteine desulfurase SufS R376A from Bacillus subtilis in L-cycloserine-inhibition | 分子名称: | 1,2-ETHANEDIOL, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, Cysteine desulfurase SufS, ... | 著者 | Nakamura, R, Takahashi, Y, Fujishiro, T. | 登録日 | 2021-02-22 | 公開日 | 2022-03-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | Cycloserine enantiomers inhibit PLP-dependent cysteine desulfurase SufS via distinct mechanisms. Febs J., 289, 2022
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7BY5
 
 | Tetanus neurotoxin mutant-(H233A/E234Q/H237A/Y375F) | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ... | 著者 | Zhang, C.M, Imoto, Y, Fukuda, Y, Yamashita, E, Inoue, T. | 登録日 | 2020-04-21 | 公開日 | 2021-02-17 | 最終更新日 | 2024-11-20 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Structural flexibility of the tetanus neurotoxin revealed by crystallographic and solution scattering analyses. J Struct Biol X, 5, 2021
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7BEC
 
 | Unusual structural features in the adduct of dirhodium tetraacetate with lysozyme (5) | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Lysozyme, ... | 著者 | Loreto, D, Ferraro, G, Merlino, A. | 登録日 | 2020-12-23 | 公開日 | 2021-02-24 | 最終更新日 | 2024-11-13 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Unusual Structural Features in the Adduct of Dirhodium Tetraacetate with Lysozyme. Int J Mol Sci, 22, 2021
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7BEB
 
 | Unusual structural features in the adduct of dirhodium tetraacetate with lysozyme (4) | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Lysozyme, ... | 著者 | Loreto, D, Ferraro, G, Merlino, A. | 登録日 | 2020-12-23 | 公開日 | 2021-02-24 | 最終更新日 | 2024-11-20 | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | 主引用文献 | Unusual Structural Features in the Adduct of Dirhodium Tetraacetate with Lysozyme. Int J Mol Sci, 22, 2021
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5X4M
 
 | Crystal structure of the BCL6 BTB domain in complex with Compound 1 | 分子名称: | B-cell lymphoma 6 protein, N-phenyl-1,3,5-triazine-2,4-diamine | 著者 | Sogabe, S, Ida, K, Lane, W, Snell, G. | 登録日 | 2017-02-13 | 公開日 | 2017-05-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Discovery of a B-Cell Lymphoma 6 Protein-Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach J. Med. Chem., 60, 2017
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8DQK
 
 | Intermediate resolution structure of barley (1,3;1,4)-beta-glucan synthase CslF6. | 分子名称: | Cellulose synthase-like CslF6 | 著者 | Ho, R, Purushotham, P, Zimmer, J. | 登録日 | 2022-07-19 | 公開日 | 2022-11-30 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Mechanism of mixed-linkage glucan biosynthesis by barley cellulose synthase-like CslF6 (1,3;1,4)-beta-glucan synthase. Sci Adv, 8, 2022
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3IUB
 
 | Crystal structure of pantothenate synthetase from Mycobacterium tuberculosis in complex with 5-Methoxy-N-(5-methylpyridin-2-ylsulfonyl)-1H-indole-2-carboxamide | 分子名称: | 1,2-ETHANEDIOL, 5-methoxy-N-[(5-methylpyridin-2-yl)sulfonyl]-1H-indole-2-carboxamide, ETHANOL, ... | 著者 | Silvestre, H.L, Hung, A.W, Wen, S, Ciulli, A, Blundell, T.L, Abell, C. | 登録日 | 2009-08-31 | 公開日 | 2009-10-13 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase. Angew.Chem.Int.Ed.Engl., 48, 2009
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6B8O
 
 | WT Ig-like V Domain with Phosphatidylserine | 分子名称: | 1,2-DICAPROYL-SN-PHOSPHATIDYL-L-SERINE, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Sudom, A, Wang, Z. | 登録日 | 2017-10-09 | 公開日 | 2018-06-27 | 最終更新日 | 2024-11-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2. J. Biol. Chem., 293, 2018
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7BE1
 
 | X-ray structure of Hen Egg White Lysozyme with dirhodium tetraacetate (3) | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Lysozyme, ... | 著者 | Loreto, D, Merlino, A, Ferraro, G. | 登録日 | 2020-12-22 | 公開日 | 2021-02-24 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Unusual Structural Features in the Adduct of Dirhodium Tetraacetate with Lysozyme. Int J Mol Sci, 22, 2021
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7BE0
 
 | X-ray structure of Hen Egg White Lysozyme with dirhodium tetraacetate (2) | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Lysozyme, ... | 著者 | Loreto, D, Merlino, A, Ferraro, G. | 登録日 | 2020-12-22 | 公開日 | 2021-02-24 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Unusual Structural Features in the Adduct of Dirhodium Tetraacetate with Lysozyme. Int J Mol Sci, 22, 2021
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6B3V
 
 | PANK3 complex with compound PZ-2891 | 分子名称: | 1,2-ETHANEDIOL, 6-(4-{[4-(propan-2-yl)phenyl]acetyl}piperazin-1-yl)pyridazine-3-carbonitrile, MAGNESIUM ION, ... | 著者 | White, S.W, Yun, M. | 登録日 | 2017-09-25 | 公開日 | 2018-08-29 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.601 Å) | 主引用文献 | A therapeutic approach to pantothenate kinase associated neurodegeneration. Nat Commun, 9, 2018
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5GN5
 
 | Crystal structure of glycerol kinase from Trypanosoma brucei gambiense complexed with cumarin derivative-17 | 分子名称: | 4-[[4-(4-methoxyphenyl)piperazin-1-yl]methyl]-7,8-bis(oxidanyl)chromen-2-one, GLYCEROL, Glycerol kinase | 著者 | Balogun, E.O, Inaoka, D.K, Shiba, T, Tsuge, T, May, B, Sato, T, Kido, Y, Takeshi, N, Aoki, T, Honma, T, Tanaka, A, Inoue, M, Matsuoka, S, Michels, P.A.M, Watanabe, Y, Moore, A.L, Harada, S, Kita, K. | 登録日 | 2016-07-19 | 公開日 | 2017-07-26 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase ofTrypanosoma brucei brucei. Faseb J., 33, 2019
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7EBA
 
 | Co-crystal of kurarinone with sEH | 分子名称: | (2S)-2-[2,4-bis(oxidanyl)phenyl]-5-methoxy-8-[(2R)-5-methyl-2-prop-1-en-2-yl-hex-4-enyl]-7-oxidanyl-2,3-dihydrochromen-4-one, Bifunctional epoxide hydrolase 2 | 著者 | Sun, C.P, Ma, X.C. | 登録日 | 2021-03-09 | 公開日 | 2022-03-09 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal model. Proc.Natl.Acad.Sci.USA, 119, 2022
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8TSM
 
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8D10
 
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8OQY
 
 | Structure of apo form of human gamma-secretase PSEN1 APH-1B isoform reconstituted into lipid nanodisc | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Odorcic, I, Chavez Gutierrez, L, Efremov, R.G. | 登録日 | 2023-04-12 | 公開日 | 2024-04-24 | 最終更新日 | 2024-10-23 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Apo and A beta 46-bound gamma-secretase structures provide insights into amyloid-beta processing by the APH-1B isoform. Nat Commun, 15, 2024
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7V9M
 
 | Cryo-EM structure of the GHRH-bound human GHRHR splice variant 1 complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Cong, Z.T, Zhou, F.L, Zhang, C, Zou, X.Y, Zhang, H.B, Wang, Y.Z, Zhou, Q.T, Cai, X.Q, Liu, Q.F, Li, J, Shao, L.J, Mao, C.Y, Wang, X, Wu, J.H, Xia, T, Zhao, L.H, Jiang, H.L, Zhang, Y, Xu, H.E, Chen, X, Yang, D.H, Wang, M.W. | 登録日 | 2021-08-26 | 公開日 | 2021-10-20 | 最終更新日 | 2025-07-02 | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | 主引用文献 | Constitutive signal bias mediated by the human GHRHR splice variant 1. Proc.Natl.Acad.Sci.USA, 118, 2021
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4TPL
 
 | West Nile Virus Non-structural protein 1 (NS1) Form 1 crystal | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, OXTOXYNOL-10, ... | 著者 | Akey, D.L, Smith, J.L. | 登録日 | 2014-06-08 | 公開日 | 2014-10-15 | 最終更新日 | 2024-11-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Use of massively multiple merged data for low-resolution S-SAD phasing and refinement of flavivirus NS1. Acta Crystallogr.,Sect.D, 70, 2014
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9AY7
 
 | Crystal structure of CRAF/MEK1 complex with NST-628 and inactive RAF | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Dual specificity mitogen-activated protein kinase kinase 1, ... | 著者 | Quade, B, Huang, X. | 登録日 | 2024-03-07 | 公開日 | 2024-04-17 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024
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4ZSE
 
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5A66
 
 | Crystal structure of AtTTM3 in complex with tripolyphosphate and manganese ion (form A) | 分子名称: | 1,2-ETHANEDIOL, MANGANESE (II) ION, TRIPHOSPHATE, ... | 著者 | Martinez, J, Truffault, V, Hothorn, M. | 登録日 | 2015-06-24 | 公開日 | 2015-08-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural Determinants for Substrate Binding and Catalysis in Triphosphate Tunnel Metalloenzymes. J.Biol.Chem., 290, 2015
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9AXX
 
 | Crystal structure of BRAF/MEK1 complex with NST-628 and an active RAF dimer | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Dual specificity mitogen-activated protein kinase kinase 1, ... | 著者 | Quade, B, Huang, X. | 登録日 | 2024-03-06 | 公開日 | 2024-04-17 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024
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6EWB
 
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7REN
 
 | Room temperature serial crystal structure of Glutaminase C in complex with inhibitor UPGL-00004 | 分子名称: | 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}amino)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial | 著者 | Milano, S.K, Finke, A, Cerione, R.A. | 登録日 | 2021-07-13 | 公開日 | 2022-05-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | New insights into the molecular mechanisms of glutaminase C inhibitors in cancer cells using serial room temperature crystallography. J.Biol.Chem., 298, 2022
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