7E6F

Crystal structure of PMP-bound form of cysteine desulfurase SufS R376A from Bacillus subtilis in L-cycloserine-inhibition

Summary for 7E6F

Entry DOI	10.2210/pdb7e6f/pdb
Descriptor	Cysteine desulfurase SufS, DI(HYDROXYETHYL)ETHER, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, ... (5 entities in total)
Functional Keywords	cysteine desulfurase, plp-dependent enzyme, cysteine metabolism, cycloserine, inhibitor, fe-s cluster biosynthesis, biosynthetic protein
Biological source	Bacillus subtilis subsp. subtilis str. 168
Total number of polymer chains	1
Total formula weight	46916.83
Authors	Nakamura, R.,Takahashi, Y.,Fujishiro, T. (deposition date: 2021-02-22, release date: 2022-03-02, Last modification date: 2023-11-29)
Primary citation	Nakamura, R.,Ogawa, S.,Takahashi, Y.,Fujishiro, T. Cycloserine enantiomers inhibit PLP-dependent cysteine desulfurase SufS via distinct mechanisms. Febs J., 289:5947-5970, 2022 Cited by PubMed: 35395703 DOI: 10.1111/febs.16455 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.74 Å)

Structure validation