7EBA

Co-crystal of kurarinone with sEH

Summary for 7EBA

• Entry DOI: 10.2210/pdb7eba/pdb
• Descriptor: Bifunctional epoxide hydrolase 2, (2S)-2-[2,4-bis(oxidanyl)phenyl]-5-methoxy-8-[(2R)-5-methyl-2-prop-1-en-2-yl-hex-4-enyl]-7-oxidanyl-2,3-dihydrochromen-4-one (3 entities in total)
• Functional Keywords: seh, inhibitor, kurarinone, hydrolase, interaction, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 77276.65

Authors

Sun, C.P.,Ma, X.C. (deposition date: 2021-03-09, release date: 2022-03-09, Last modification date: 2023-11-29)

• Primary citation: Sun, C.P.,Zhou, J.J.,Yu, Z.L.,Huo, X.K.,Zhang, J.,Morisseau, C.,Hammock, B.D.,Ma, X.C.; Kurarinone alleviated Parkinson's disease via stabilization of epoxyeicosatrienoic acids in animal model.; Proc.Natl.Acad.Sci.USA, 119:e2118818119-e2118818119, 2022; PubMed: 35217618; DOI: 10.1073/pnas.2118818119

Experimental method

X-RAY DIFFRACTION (2.3 Å)