7EBA

Co-crystal of kurarinone with sEH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
B	0003824	molecular_function	catalytic activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue J0U A 601

Chain	Residue
A	ASP335
A	PHE381
A	GLN384
A	TYR466
A	MET469
A	ASN472
A	MET503
A	HOH740
A	TRP336
A	MET339
A	TYR343
A	THR360
A	PRO361
A	ILE363
A	PRO364
A	ALA365

---

site_id	AC2
Number of Residues	13
Details	binding site for residue J0U B 601

Chain	Residue
B	ASP335
B	TRP336
B	MET339
B	TYR343
B	ILE363
B	PRO364
B	ALA365
B	PHE381
B	GLN384
B	TYR466
B	MET469
B	ASN472
B	HOH767

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	544
Details	Domain: {"description":"AB hydrolase-1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"15096040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16322563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19746975","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19969453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20934334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"15096040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16322563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19746975","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19969453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20934334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"15096040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16322563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19746975","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19969453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20934334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15096040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16322563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19746975","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19969453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20934334","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P34914","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P34914","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Lipidation: {"description":"S-(15-deoxy-Delta12,14-prostaglandin J2-9-yl)cysteine","evidences":[{"source":"PubMed","id":"21164107","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---