5GN5

Crystal structure of glycerol kinase from Trypanosoma brucei gambiense complexed with cumarin derivative-17

Summary for 5GN5

Entry DOI	10.2210/pdb5gn5/pdb
Related	3WXI 5GN6 5GN7 5GN9
Descriptor	Glycerol kinase, 4-[[4-(4-methoxyphenyl)piperazin-1-yl]methyl]-7,8-bis(oxidanyl)chromen-2-one, GLYCEROL, ... (4 entities in total)
Functional Keywords	glycerol kinase, inhibitor, drug, african trypanosomes, transferase
Biological source	Trypanosoma brucei gambiense
Total number of polymer chains	4
Total formula weight	228322.52
Authors	Balogun, E.O.,Inaoka, D.K.,Shiba, T.,Tsuge, T.,May, B.,Sato, T.,Kido, Y.,Takeshi, N.,Aoki, T.,Honma, T.,Tanaka, A.,Inoue, M.,Matsuoka, S.,Michels, P.A.M.,Watanabe, Y.,Moore, A.L.,Harada, S.,Kita, K. (deposition date: 2016-07-19, release date: 2017-07-26, Last modification date: 2023-11-08)
Primary citation	Balogun, E.O.,Inaoka, D.K.,Shiba, T.,Tsuge, C.,May, B.,Sato, T.,Kido, Y.,Nara, T.,Aoki, T.,Honma, T.,Tanaka, A.,Inoue, M.,Matsuoka, S.,Michels, P.A.M.,Watanabe, Y.I.,Moore, A.L.,Harada, S.,Kita, K. Discovery of trypanocidal coumarins with dual inhibition of both the glycerol kinase and alternative oxidase ofTrypanosoma brucei brucei. Faseb J., 33:13002-13013, 2019 Cited by PubMed: 31525300 DOI: 10.1096/fj.201901342R PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation