7REN

Room temperature serial crystal structure of Glutaminase C in complex with inhibitor UPGL-00004

Summary for 7REN

Entry DOI	10.2210/pdb7ren/pdb
Descriptor	Glutaminase kidney isoform, mitochondrial, 2-phenyl-N-{5-[4-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}amino)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide (3 entities in total)
Functional Keywords	hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	238899.67
Authors	Milano, S.K.,Finke, A.,Cerione, R.A. (deposition date: 2021-07-13, release date: 2022-05-25, Last modification date: 2023-10-18)
Primary citation	Milano, S.K.,Huang, Q.,Nguyen, T.T.,Ramachandran, S.,Finke, A.,Kriksunov, I.,Schuller, D.J.,Szebenyi, D.M.,Arenholz, E.,McDermott, L.A.,Sukumar, N.,Cerione, R.A.,Katt, W.P. New insights into the molecular mechanisms of glutaminase C inhibitors in cancer cells using serial room temperature crystallography. J.Biol.Chem., 298:101535-101535, 2022 Cited by PubMed: 34954143 DOI: 10.1016/j.jbc.2021.101535 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation