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PDB: 18 件
5CVD
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Crystal structure of human NRMT1 in complex with alpha-N-dimethylated human CENP-A peptide
分子名称: N-teminal peptide from Histone H3-like centromeric protein A, N-terminal Xaa-Pro-Lys N-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE
著者Wu, R, Li, H.
登録日2015-07-26
公開日2015-11-25
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Molecular basis for histone N-terminal methylation by NRMT1
Genes Dev., 29, 2015
6WJ7
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BU of 6wj7 by Molmil
The structure of NTMT1 in complex with compound C2A
分子名称: 5'-{[(3S)-3-amino-3-carboxypropyl](ethyl)amino}-5'-deoxyadenosine, GLY-PRO-LYS-ARG-ILE-ALA-NH2, N-terminal Xaa-Pro-Lys N-methyltransferase 1
著者Srinivasan, K, Chen, D, Huang, R, Noinaj, N.
登録日2020-04-13
公開日2020-08-19
最終更新日2024-04-24
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogues.
J.Med.Chem., 63, 2020
5E1D
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NTMT1 in complex with YPKRIA peptide
分子名称: GLYCEROL, N-terminal Xaa-Pro-Lys N-methyltransferase 1, RCC1, ...
著者Dong, C, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
登録日2015-09-29
公開日2015-10-28
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structural basis for substrate recognition by the human N-terminal methyltransferase 1.
Genes Dev., 29, 2015
6DTN
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The structure of NTMT1 in complex with compound DC100-1
分子名称: (6D6)PPKRIA(NH2), DC100-1, N-terminal Xaa-Pro-Lys N-methyltransferase 1
著者Noinaj, N, Chen, D, Huang, R.
登録日2018-06-18
公開日2019-04-03
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.475 Å)
主引用文献Discovery of Bisubstrate Inhibitors for Protein N-Terminal Methyltransferase 1.
J. Med. Chem., 62, 2019
6KDQ
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BU of 6kdq by Molmil
Crystal structure of human NRMT1 in complex with alpha-N-monomethylated human CENP-A peptide
分子名称: CENP-A peptide, N-terminal Xaa-Pro-Lys N-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE
著者Yue, Y, Li, H.
登録日2019-07-02
公開日2020-07-08
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.499 Å)
主引用文献Substrate engagement regulates state-specific alpha-N methylation of CENP-A by NRMT2
to be published
6PVB
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BU of 6pvb by Molmil
The structure of NTMT1 in complex with compound 6
分子名称: AMINO GROUP-()-(2~{S})-2-azanylpropanal-()-ISOLEUCINE-()-ARGININE-()-LYSINE-()-PROLINE-()-AMINO-ACETALDEHYDE-()-9-(5-{[(3S)-3-amino-3-carboxypropyl](pentyl)amino}-5-deoxy-beta-L-arabinofuranosyl)-9H-purin-6-amine, N-terminal Xaa-Pro-Lys N-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE
著者Noinaj, N, Chen, D, Huang, R.
登録日2019-07-20
公開日2020-08-19
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogues.
J.Med.Chem., 63, 2020
5CVE
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Crystal Structure of human NRMT1 in complex with dimethylated fly H2B peptide and SAH
分子名称: N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminal peptide from Histone H2B, S-ADENOSYL-L-HOMOCYSTEINE
著者Wu, R, Li, H.
登録日2015-07-26
公開日2015-11-25
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Molecular basis for histone N-terminal methylation by NRMT1
Genes Dev., 29, 2015
5E1B
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Crystal structure of NRMT1 in complex with SPKRIA peptide
分子名称: GLYCEROL, N-terminal Xaa-Pro-Lys N-methyltransferase 1, RCC1, ...
著者Dong, C, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
登録日2015-09-29
公開日2015-10-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural basis for substrate recognition by the human N-terminal methyltransferase 1.
Genes Dev., 29, 2015
6WH8
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The structure of NTMT1 in complex with compound BM-30
分子名称: 4HP-PRO-LYS-ARG-NH2, BM-30, N-terminal Xaa-Pro-Lys N-methyltransferase 1, ...
著者Noinaj, N, Chen, D, Huang, R.
登録日2020-04-07
公開日2020-08-26
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.729 Å)
主引用文献Selective Peptidomimetic Inhibitors of NTMT1/2: Rational Design, Synthesis, Characterization, and Crystallographic Studies.
J.Med.Chem., 63, 2020
5E1M
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Crystal structure of NTMT1 in complex with PPKRIA peptide
分子名称: GLYCEROL, N-terminal Xaa-Pro-Lys N-methyltransferase 1, RCC1, ...
著者Dong, C, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
登録日2015-09-29
公開日2015-10-28
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural basis for substrate recognition by the human N-terminal methyltransferase 1.
Genes Dev., 29, 2015
5E2A
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BU of 5e2a by Molmil
Crystal structure of NTMT1 in complex with N-terminally methylated SPKRIA peptide
分子名称: GLYCEROL, N-terminal Xaa-Pro-Lys N-methyltransferase 1, RCC1, ...
著者Dong, C, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
登録日2015-09-30
公開日2015-10-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural basis for substrate recognition by the human N-terminal methyltransferase 1.
Genes Dev., 29, 2015
2EX4
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BU of 2ex4 by Molmil
Crystal Structure of Human methyltransferase AD-003 in complex with S-adenosyl-L-homocysteine
分子名称: S-ADENOSYL-L-HOMOCYSTEINE, adrenal gland protein AD-003
著者Min, J.R, Wu, H, Zeng, H, Loppnau, P, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC)
登録日2005-11-07
公開日2005-11-15
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献The Crystal Structure of Human AD-003 protein in complex with S-adenosyl-L-homocysteine
To be Published
6PVA
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BU of 6pva by Molmil
The structure of NTMT1 in complex with compound 11
分子名称: AMINO GROUP-()-LYSINE-()-LYSINE-()-PROLINE-()-AMINO-ACETALDEHYDE-()-5'-{[(3S)-3-amino-3-carboxypropyl](3-aminopropyl)amino}-5'-deoxyadenosine, N-terminal Xaa-Pro-Lys N-methyltransferase 1
著者Noinaj, N, Chen, D, Huang, R.
登録日2019-07-20
公開日2020-08-19
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献The structure of NTMT1 in complex with compound 11
To Be published
5E2B
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BU of 5e2b by Molmil
Crystal structure of NTMT1 in complex with N-terminally methylated PPKRIA peptide
分子名称: GLYCEROL, N-terminal Xaa-Pro-Lys N-methyltransferase 1, RCC1, ...
著者Dong, C, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
登録日2015-09-30
公開日2015-10-28
最終更新日2015-12-02
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural basis for substrate recognition by the human N-terminal methyltransferase 1.
Genes Dev., 29, 2015
5E1O
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BU of 5e1o by Molmil
Crystal structure of NTMT1 in complex with RPKRIA peptide
分子名称: GLYCEROL, N-terminal Xaa-Pro-Lys N-methyltransferase 1, RCC1, ...
著者Dong, C, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
登録日2015-09-29
公開日2015-10-28
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for substrate recognition by the human N-terminal methyltransferase 1.
Genes Dev., 29, 2015
7K3D
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BU of 7k3d by Molmil
The structure of NTMT1 in complex with compound DC1-13
分子名称: N-terminal Xaa-Pro-Lys N-methyltransferase 1, N~2~-{(2S)-1-[(naphthalen-1-yl)acetyl]-2,5-dihydro-1H-pyrrole-2-carbonyl}-L-lysyl-L-argininamide, S-ADENOSYL-L-HOMOCYSTEINE
著者Chen, D, Huang, R, Noinaj, N.
登録日2020-09-11
公開日2021-04-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献Structure-based Discovery of Cell-Potent Peptidomimetic Inhibitors for Protein N-Terminal Methyltransferase 1.
Acs Med.Chem.Lett., 12, 2021
7SS1
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The structure of NTMT1 in complex with compound GD433
分子名称: (1R,3S,4R)-1-azabicyclo[2.2.2]octan-3-yl {2-[2-(4-fluoro-3-hydroxyphenyl)-1,3-thiazol-4-yl]propan-2-yl}carbamate, N-terminal Xaa-Pro-Lys N-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE
著者Yadav, R, Guangping, D, Deng, Y, Huang, R, Noinaj, N.
登録日2021-11-09
公開日2022-11-16
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Discovery of a first-in-class small molecule inhibitor for Protein N-terminal methyltransferases 1/2
To Be Published
7U1M
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Crystal structure of NTMT1 in complex with compound YD206
分子名称: (1R,3S,4R)-1-azabicyclo[2.2.2]octan-3-yl {2-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]propan-2-yl}carbamate, N-terminal Xaa-Pro-Lys N-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE
著者Yadav, R, Noinaj, N.
登録日2022-02-21
公開日2022-12-14
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.17 Å)
主引用文献Venglustat Inhibits Protein N-Terminal Methyltransferase 1 in a Substrate-Competitive Manner.
J.Med.Chem., 65, 2022

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件を2024-07-10に公開中

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