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PDB: 93 件
7ZWL
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Crystal structure of human STING in complex with 3',3'-c-di-(2'F,2'dAMP)
分子名称: 9-[(1~{R},6~{R},8~{R},9~{S},10~{R},15~{R},17~{R},18~{S})-17-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,11,13-tetraoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadecan-8-yl]purin-6-amine, Stimulator of interferon protein, Ubiquitin-like protein SMT3
著者Klima, M, Smola, M, Boura, E.
登録日2022-05-19
公開日2023-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of human STING in complex with 3',3'-c-di-(2'F,2'dAMP)
To Be Published
5JEJ
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Phosphorylated STING in complex with IRF-3 CTD
分子名称: Interferon regulatory factor 3, Stimulator of interferon genes protein
著者Li, P, Shu, C.
登録日2016-04-18
公開日2016-06-15
最終更新日2016-06-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins.
Proc.Natl.Acad.Sci.USA, 113, 2016
5BQX
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Crystal structure of human STING in complex with 3'2'-cGAMP
分子名称: 3'2'-cGAMP, Stimulator of interferon genes protein
著者Wu, J, Zhang, X, Chen, Z.J, Chen, C.
登録日2015-05-29
公開日2015-06-24
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING.
Proc.Natl.Acad.Sci.USA, 112, 2015
8T5L
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Crystal structure of STING CTD in complex with 2'3'-cGAMP
分子名称: Stimulator of interferon genes protein, cGAMP
著者Li, Y, Li, P, Sun, D.
登録日2023-06-13
公開日2023-07-12
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Structural and Biological Evaluations of a Non-Nucleoside STING Agonist Specific for Human STING A230 Variants.
Biorxiv, 2023
6S26
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Crystal structure of human wild type STING in complex with 2'-3'-cyclic-GMP-7-deaza-AMP
分子名称: 2-azanyl-9-[(1~{R},6~{R},8~{R},9~{R},10~{S},15~{R},17~{R},18~{R})-8-(4-azanylpyrrolo[2,3-d]pyrimidin-7-yl)-3,9,12,18-tetrakis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one, Stimulator of interferon protein
著者Boura, E, Smola, M, Brynda, J.
登録日2019-06-20
公開日2019-11-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Enzymatic Preparation of 2'-5',3'-5'-Cyclic Dinucleotides, Their Binding Properties to Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations.
J.Med.Chem., 62, 2019
8P01
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Crystal structure of human STING ectodomain in complex with BI 7446, a potent cyclic dinucleotide STING agonist with broad-spectrum variant activity for the treatment of cancer
分子名称: 3-[(1~{R},3~{R},6~{R},8~{R},9~{R},10~{R},12~{R},15~{R},17~{R},18~{R})-8-(6-aminopurin-9-yl)-9-fluoranyl-18-oxidanyl-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-6~{H}-imidazo[4,5-d]pyridazin-7-one, Stimulator of interferon genes protein
著者Nar, H.
登録日2023-05-09
公開日2023-07-26
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.094 Å)
主引用文献Discovery of BI 7446: A Potent Cyclic Dinucleotide STING Agonist with Broad-Spectrum Variant Activity for the Treatment of Cancer.
J.Med.Chem., 66, 2023
4EF4
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Crystal structure of STING CTD complex with c-di-GMP
分子名称: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CALCIUM ION, Transmembrane protein 173
著者Ouyang, S, Ru, H, Shaw, N, Jiang, Y, Niu, F, Zhu, Y, Qiu, W, Li, Y, Liu, Z.-J.
登録日2012-03-29
公開日2012-05-16
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.147 Å)
主引用文献Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding
Immunity, 36, 2012
8A2I
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human STING in complex with 2'-3'-cyclic-GMP-7-deaza(4-(2-naphthyl)phenyl)-AMP
分子名称: 2-azanyl-9-[(1~{R},6~{R},8~{R},9~{R},10~{S},15~{R},17~{R},18~{R})-8-[4-azanyl-5-(4-naphthalen-2-ylphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,9,12,18-tetrakis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-3~{H}-purin-6-one, Stimulator of interferon genes protein
著者Vavrina, Z, Brynda, J, Rezacova, P.
登録日2022-06-03
公開日2022-10-12
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists.
J.Med.Chem., 65, 2022
8B2J
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Crystal structure of human STING in complex with ADU-S100
分子名称: (1~{R},3~{S},6~{R},8~{R},9~{R},10~{S},12~{S},15~{R},17~{R},18~{R})-8,17-bis(6-aminopurin-9-yl)-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecane-9,18-diol, CALCIUM ION, SODIUM ION, ...
著者Nawrotek, A, Vuillard, L, Miallau, L.
登録日2022-09-14
公開日2022-11-30
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.174 Å)
主引用文献Crystal structure of human STING in complex with ADU-S100
To Be Published
7SHP
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Crystal structure of hSTING in complex with c[2',3'-(ribo-2'-G, xylo-3'-A)-MP](RJ244)
分子名称: (2S,5R,7R,8R,10S,12aR,14R,15R,15aR,16R)-7-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-2,10,15,16-tetrahydroxyoctahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, Stimulator of interferon genes protein
著者Xie, W, Lama, L, Yang, X.J, Kuryavyi, V, Nudelman, I, Glickman, J.F, Jones, R.A, Tuschl, T, Patel, D.J.
登録日2021-10-11
公開日2022-10-19
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Arabinose- and xylose-modified analogs of 2',3'-cGAMP act as STING agonists.
Cell Chem Biol, 2023
6CY7
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Human Stimulator of Interferon Genes
分子名称: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, GLYCEROL, IMIDAZOLE, ...
著者Fernandez, D, Li, L, Ergun, S.L.
登録日2018-04-04
公開日2019-03-13
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition.
Cell, 178, 2019
4F5W
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Crystal structure of ligand free human STING CTD
分子名称: CALCIUM ION, Transmembrane protein 173
著者Gu, L, Shang, G, Zhu, D, Li, N, Zhang, J, Zhu, C, Lu, D, Liu, C, Yu, Q, Zhao, Y, Xu, S.
登録日2012-05-13
公開日2012-06-27
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.201 Å)
主引用文献Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP
Nat.Struct.Mol.Biol., 19, 2012
7SHO
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Crystal structure of hSTING in complex with c[2',3'-(ara-2'-G, ribo-3'-A)-MP] (RJ242)
分子名称: (2R,5R,7R,8S,10R,12aR,14R,15R,15aS,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-2,10,15,16-tetrahydroxyoctahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, Stimulator of interferon genes protein
著者Xie, W, Lama, L, Yang, X.J, Kuryavyi, V, Nudelman, I, Glickman, J.F, Jones, R.A, Tuschl, T, Patel, D.J.
登録日2021-10-10
公開日2022-10-12
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Arabinose- and xylose-modified analogs of 2',3'-cGAMP act as STING agonists.
Cell Chem Biol, 2023
4LOH
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Crystal structure of hSTING(H232) in complex with c[G(2',5')pA(3',5')p]
分子名称: Stimulator of interferon genes protein, cGAMP
著者Gao, P, Patel, D.J.
登録日2013-07-12
公開日2013-08-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structure-Function Analysis of STING Activation by c[G(2',5')pA(3',5')p] and Targeting by Antiviral DMXAA.
Cell(Cambridge,Mass.), 154, 2013
7OB3
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hSTING in complex with 3',3'-c-di-araAMP
分子名称: 3',3'-c-di-araAMP, Stimulator of interferon genes protein
著者Smola, M, Boura, E.
登録日2021-04-20
公開日2022-05-04
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Enzymatic Synthesis of 3'-5', 3'-5' Cyclic Dinucleotides, Their Binding Properties to the Stimulator of Interferon Genes Adaptor Protein, and Structure/Activity Correlations
Biochemistry, 2021
7ZV0
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Crystal structure of human STING in complex with 3',3'-c-(2'F,2'dAMP-2'F,2'dAMP)
分子名称: 9-[(1~{R},6~{R},8~{R},9~{R},10~{R},15~{R},17~{R},18~{S})-8-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadecan-17-yl]purin-6-amine, Stimulator of interferon protein
著者Klima, M, Smola, M, Boura, E.
登録日2022-05-13
公開日2023-11-22
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Crystal structure of human STING in complex with 3',3'-c-(2'F,2'dAMP-2'F,2'dAMP)
To Be Published
6YWA
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Human REF STING in complex with 3',3'-c-[2'FdAMP-2'FdAM(PS)]
分子名称: 3',3'-c-[2'FdAMP-2'FdAM(PS)], GLYCEROL, Stimulator of interferon genes protein
著者Boura, E, Smola, M.
登録日2020-04-29
公開日2021-05-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.311 Å)
主引用文献Human REF STING in complex with 3',3'-c-[2'FdAMP-2'FdAM(PS)]
To Be Published
7MHC
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Structure of human STING in complex with MK-1454
分子名称: (2R,5R,7R,8S,10R,12aR,14R,15S,15aR,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-15,16-difluoro-2,10-bis(sulfanyl)octahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, Stimulator of interferon genes protein
著者Lesburg, C.A.
登録日2021-04-15
公開日2022-04-06
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献A kinase-cGAS cascade to synthesize a therapeutic STING activator.
Nature, 603, 2022
8A2J
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human STING in complex with 2'-3'-cyclic-GMP-7-deaza(4-biphenylyl)-AMP
分子名称: 2-azanyl-9-[(1~{R},6~{R},8~{R},9~{R},10~{S},15~{R},17~{R},18~{R})-8-[4-azanyl-5-(4-phenylphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,9,12,18-tetrakis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one, Stimulator of interferon genes protein
著者Vavrina, Z, Brynda, J, Rezacova, P.
登録日2022-06-03
公開日2022-10-12
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Design, Synthesis, and Biochemical and Biological Evaluation of Novel 7-Deazapurine Cyclic Dinucleotide Analogues as STING Receptor Agonists.
J.Med.Chem., 65, 2022
7R4H
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phospho-STING binding to adaptor protein complex-1
分子名称: ADP-ribosylation factor 1, AP-1 complex subunit beta-1, AP-1 complex subunit gamma-1, ...
著者Xu, P, Ablasser, A.
登録日2022-02-08
公開日2022-09-14
最終更新日2022-11-09
実験手法ELECTRON MICROSCOPY (2.34 Å)
主引用文献Clathrin-associated AP-1 controls termination of STING signalling.
Nature, 610, 2022
7KVZ
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Structure of hSTING in complex with novel carbocyclic pyrimidine CDN-2
分子名称: (2R,5R,7R,8R,10S,12aR,14R,15aS,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2,10,16-trihydroxy-14-[(pyrimidin-4-yl)oxy]decahydro-2H,10H-5,8-methano-2lambda~5~,10lambda~5~-cyclopenta[l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, Stimulator of interferon genes protein
著者Skene, R.J.
登録日2020-11-29
公開日2022-02-09
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Identification of Novel Carbocyclic Pyrimidine Cyclic Dinucleotide STING Agonists for Antitumor Immunotherapy Using Systemic Intravenous Route.
J.Med.Chem., 64, 2021
7Q85
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Crystal structure of human STING in complex with MD1193
分子名称: 9-[(1R,6R,8R,13E,15R,17R,18R)-17-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,16-pentaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadec-13-en-8-yl]purin-6-amine, Stimulator of interferon genes protein
著者Smola, M, Klima, M, Boura, E.
登録日2021-11-10
公開日2022-10-19
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.359 Å)
主引用文献Vinylphosphonate-based cyclic dinucleotides enhance STING-mediated cancer immunotherapy.
Eur.J.Med.Chem., 259, 2023
4QXR
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Crystal structure of hSTING(S162A/G230I/Q266I) in complex with DMXAA
分子名称: (5,6-dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid, SULFATE ION, Stimulator of interferon genes protein
著者Gao, P, Patel, D.J.
登録日2014-07-21
公開日2014-09-10
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA.
Cell Rep, 8, 2014
6XF3
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Crystal structure of STING in complex with E7766
分子名称: (1R,3R,15E,28R,29R,30R,31R,34R,36R,39S,41R)-29,41-difluoro-34,39-disulfanyl-2,33,35,38,40,42-hexaoxa-4,6,9,11,13,18,20,22,25,27-decaaza-34,39-diphosphaoctacyclo[28.6.4.1~3,36~.1~28,31~.0~4,8~.0~7,12~.0~19,24~.0~23,27~]dotetraconta-5,7,9,11,15,19,21,23,25-nonaene 34,39-dioxide (non-preferred name), Stimulator of interferon genes protein
著者Chen, Y, Wang, J.Y, Kim, D.-S.
登録日2020-06-15
公開日2021-02-17
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献E7766, a Macrocycle-Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan-Genotypic Activity.
Chemmedchem, 16, 2021
4F5Y
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Crystal structure of human STING CTD complex with C-di-GMP
分子名称: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CALCIUM ION, Transmembrane protein 173
著者Gu, L, Shang, G, Zhu, D, Li, N, Zhang, J, Zhu, C, Lu, D, Liu, C, Yu, Q, Zhao, Y, Xu, S.
登録日2012-05-13
公開日2012-06-27
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.396 Å)
主引用文献Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP
Nat.Struct.Mol.Biol., 19, 2012

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