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PDB: 64 件
5IL2
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BU of 5il2 by Molmil
Crystal structure of SAH-bound METTL3-METTL14 complex
分子名称: 1,2-ETHANEDIOL, METTL14, METTL3, ...
著者Wang, X, Guan, Z, Zou, T, Yin, P.
登録日2016-03-04
公開日2016-05-25
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.606 Å)
主引用文献Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex
Nature, 534, 2016
7RX7
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BU of 7rx7 by Molmil
Structure of METTL3-METTL14(R298P) mutant methyltransferase complex
分子名称: N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase non-catalytic subunit
著者Wang, P, Nam, Y.
登録日2021-08-21
公開日2022-11-09
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.645 Å)
主引用文献Structure of METTL3-METTL14(R298P) mutant methyltransferase complex
To Be Published
5K7M
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BU of 5k7m by Molmil
Crystal structure of the catalytic domains of Mettl3/Mettl14 complex
分子名称: N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase subunit METTL14
著者Wang, P, Doxtader, K.A, Nam, Y.
登録日2016-05-26
公開日2016-07-06
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.
Mol.Cell, 63, 2016
5K7W
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BU of 5k7w by Molmil
Crystal structure of the catalytic domain of Mettl3/Mettl14 complex with SAH
分子名称: N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase subunit METTL14, S-ADENOSYL-L-HOMOCYSTEINE
著者Wang, P, Doxtader, K.A, Nam, Y.
登録日2016-05-26
公開日2016-07-06
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.
Mol.Cell, 63, 2016
5K7U
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BU of 5k7u by Molmil
Crystal structure of the catalytic domains of Mettl3/Mettl14 complex with SAM
分子名称: N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase subunit METTL14, S-ADENOSYLMETHIONINE
著者Wang, P, Doxtader, K.A, Nam, Y.
登録日2016-05-26
公開日2016-07-06
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases.
Mol.Cell, 63, 2016
5IL1
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BU of 5il1 by Molmil
Crystal structure of SAM-bound METTL3-METTL14 complex
分子名称: 1,2-ETHANEDIOL, METTL14, METTL3, ...
著者Wang, X, Guan, Z, Zou, T, Yin, P.
登録日2016-03-04
公開日2016-05-25
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex
Nature, 534, 2016
7O09
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BU of 7o09 by Molmil
Crystal structure of the human METTL3-METTL14 complex bound to Compound 7 (ADO_AC_074)
分子名称: 6-[4-[6-[(4,4-dimethylpiperidin-1-yl)methyl]pyridin-3-yl]-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl]-N-(phenylmethyl)pyrimidin-4-amine, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
著者Bedi, R.K, Dolbois, A, Caflisch, A.
登録日2021-03-25
公開日2021-09-01
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors.
J.Med.Chem., 64, 2021
5TEY
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BU of 5tey by Molmil
Human METTL3-METTL14 complex
分子名称: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, MAGNESIUM ION, ...
著者DONG, A, ZENG, H, LI, Y, TEMPEL, W, Seitova, A, Hutchinson, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, BROWN, P.J, WU, H, Structural Genomics Consortium (SGC)
登録日2016-09-23
公開日2016-11-23
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Human METTL3-METTL14 complex
to be published
7RX6
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BU of 7rx6 by Molmil
Structure of METTL3-METTL14(R298C) mutant methyltransferase complex
分子名称: N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase non-catalytic subunit
著者Wang, P, Nam, Y.
登録日2021-08-21
公開日2022-11-09
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure of METTL3-METTL14(R298C) mutant methyltransferase complex
To Be Published
7RX8
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BU of 7rx8 by Molmil
Structure of METTL3-METTL14(R298H) mutant methyltransferase complex
分子名称: N6-adenosine-methyltransferase 70 kDa subunit, N6-adenosine-methyltransferase non-catalytic subunit
著者Wang, P, Nam, Y.
登録日2021-08-21
公開日2022-11-09
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure of METTL3-METTL14(R298H) mutant methyltransferase complex
To Be Published
7NHI
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BU of 7nhi by Molmil
Crystal structure of the human METTL3-METTL14 complex with compound UOZ004
分子名称: (R)-N-((3-hydroxy-1-(6-(methylamino)pyrimidin-4-yl)piperidin-3-yl)methyl)-4-((4-methylpiperidin-1-yl)methyl)benzamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
著者Bedi, R.K, Huang, D, Caflisch, A.
登録日2021-02-10
公開日2021-09-01
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3
Acs Bio Med Chem Au, 2023
5L6D
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BU of 5l6d by Molmil
Crystal structure of the human METTL3-METTL14 complex bound to SAH
分子名称: ACETATE ION, MAGNESIUM ION, N6-adenosine-methyltransferase 70 kDa subunit, ...
著者Sledz, P, Jinek, M.
登録日2016-05-29
公開日2016-10-12
実験手法X-RAY DIFFRACTION (1.852 Å)
主引用文献Structural insights into the molecular mechanism of the m(6)A writer complex.
Elife, 5, 2016
7OEL
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BU of 7oel by Molmil
Crystal structure of the human METTL3-METTL14 complex with compound UOZ097
分子名称: ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, ...
著者Bedi, R.K, Huang, D, Caflisch, A.
登録日2021-05-03
公開日2021-10-20
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3
Acs Bio Med Chem Au, 2023
5IL0
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BU of 5il0 by Molmil
Crystal structural of the METTL3-METTL14 complex for N6-adenosine methylation
分子名称: 1,2-ETHANEDIOL, BROMIDE ION, METTL14, ...
著者Wang, X, Guan, Z, Zou, T, Yin, P.
登録日2016-03-04
公開日2016-05-25
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.882 Å)
主引用文献Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex
Nature, 534, 2016
7O0L
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BU of 7o0l by Molmil
Crystal structure of the human METTL3-METTL14 complex bound to Compound 8 (ADO_AC_093)
分子名称: 4-[6-[(4,4-dimethylpiperidin-1-yl)methyl]pyridin-3-yl]-9-[6-[(phenylmethyl)amino]pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
著者Bedi, R.K, Dolbois, A, Caflisch, A.
登録日2021-03-26
公開日2021-09-01
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors.
J.Med.Chem., 64, 2021
7OEK
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BU of 7oek by Molmil
Crystal structure of the human METTL3-METTL14 complex with compound UOZ091
分子名称: 4-[[(3S)-3-cyclopropyl-2-azaspiro[3.3]heptan-2-yl]methyl]-2-oxidanyl-N-[[(3R)-3-oxidanyl-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-3-yl]methyl]benzamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
著者Bedi, R.K, Huang, D, Caflisch, A.
登録日2021-05-03
公開日2021-10-20
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3
Acs Bio Med Chem Au, 2023
6Y4G
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BU of 6y4g by Molmil
Crystal structure of the human METTL3-METTL14 complex bound to Sinefungin
分子名称: ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, ...
著者Bedi, R.K, Omori, E, Caflisch, A.
登録日2020-02-20
公開日2020-03-04
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Small-Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer.
Chemmedchem, 15, 2020
5L6E
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BU of 5l6e by Molmil
Crystal structure of the human METTL3-METTL14 complex bound to SAM
分子名称: ACETATE ION, MAGNESIUM ION, N6-adenosine-methyltransferase 70 kDa subunit, ...
著者Sledz, P, Jinek, M.
登録日2016-05-29
公開日2016-10-12
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (1.901 Å)
主引用文献Structural insights into the molecular mechanism of the m(6)A writer complex.
Elife, 5, 2016
7NHV
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BU of 7nhv by Molmil
Crystal structure of the human METTL3-METTL14 complex with compound UOZ016
分子名称: (R)-N-((1-(6-(benzylamino)pyrimidin-4-yl)-3-hydroxypiperidin-3-yl)methyl)-4-((4,4-dimethylpiperidin-1-yl)methyl)benzamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
著者Bedi, R.K, Huang, D, Caflisch, A.
登録日2021-02-11
公開日2021-10-20
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3
Acs Bio Med Chem Au, 2023
7O08
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BU of 7o08 by Molmil
Crystal structure of the human METTL3-METTL14 complex bound to Compound 5 (ADO_AB_075)
分子名称: 4-[[[6-[(4,4-dimethylpiperidin-1-yl)methyl]pyridin-3-yl]amino]methyl]-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-4-ol, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
著者Bedi, R.K, Dolbois, A, Caflisch, A.
登録日2021-03-25
公開日2021-09-01
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors.
J.Med.Chem., 64, 2021
7OED
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BU of 7oed by Molmil
Crystal structure of the human METTL3-METTL14 complex with compound UOZ019a
分子名称: 4-[(4,4-dimethylpiperidin-1-yl)methyl]-~{N}-[[(3~{R})-1-[6-(methylamino)pyrimidin-4-yl]-3-oxidanyl-piperidin-3-yl]methyl]-2-oxidanyl-benzamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
著者Bedi, R.K, Huang, D, Caflisch, A.
登録日2021-05-03
公開日2021-10-20
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3
Acs Bio Med Chem Au, 2023
7OQP
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BU of 7oqp by Molmil
Crystal structure of the human METTL3-METTL14 complex with compound UOZ113
分子名称: ACETATE ION, N-[[(3R)-1-[6-(1-benzothiophen-4-ylmethylamino)pyrimidin-4-yl]-3-oxidanyl-piperidin-3-yl]methyl]-2-oxidanyl-4-[[(3S)-3-propan-2-yl-2-azaspiro[3.3]heptan-2-yl]methyl]benzamide, N6-adenosine-methyltransferase catalytic subunit, ...
著者Bedi, R.K, Huang, D, Caflisch, A.
登録日2021-06-03
公開日2021-10-20
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3
Acs Bio Med Chem Au, 2023
6TTP
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BU of 6ttp by Molmil
Crystal structure of the human METTL3-METTL14 complex bound to Compound 1/Adenosine (DHU_M3M_023)
分子名称: ACETATE ION, ADENOSINE, N6-adenosine-methyltransferase catalytic subunit, ...
著者Bedi, R.K, Huang, D, Sledz, P, Caflisch, A.
登録日2019-12-30
公開日2020-03-04
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Small-Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer.
Chemmedchem, 15, 2020
6TTX
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BU of 6ttx by Molmil
Crystal structure of the human METTL3-METTL14 complex bound to Compound 5 (ASI_M3M_051)
分子名称: (2~{S},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)-~{N}-(piperidin-4-ylmethyl)oxolane-2-carboxamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
著者Bedi, R.K, Huang, D, Sledz, P, Caflisch, A.
登録日2019-12-30
公開日2020-03-04
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Small-Molecule Inhibitors of METTL3, the Major Human Epitranscriptomic Writer.
Chemmedchem, 15, 2020
7OEH
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BU of 7oeh by Molmil
Crystal structure of the human METTL3-METTL14 complex with compound UOZ059b
分子名称: 4-[[(3S)-3-cyclopropyl-2-azaspiro[3.3]heptan-2-yl]methyl]-N-[[(3S)-3-oxidanyl-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-3-yl]methyl]benzamide, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ...
著者Bedi, R.K, Huang, D, Caflisch, A.
登録日2021-05-03
公開日2021-10-20
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Structure-Based Design of Inhibitors of the m6A-RNA Writer Enzyme METTL3
Acs Bio Med Chem Au, 2023

 

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